Healthy volunteers

This study is checking the safety of a high-dose flu vaccine called Efluelda in adults aged 65 and older in South Korea. About 670 participants will receive one shot and be monitored for side effects for about a month. The goal is to see how often reactions like injection site pa…

Researchers are testing an experimental drug called MWN117 to see if it is safe and how the body handles it. The trial enrolls 48 healthy and obese Chinese adults who receive a single injection under the skin of either MWN117 or a placebo. Participants are split into groups that …

This trial tests an experimental medicine called NNC0705-0002 in healthy adults. The drug aims to address conditions where inflammation may contribute to heart and metabolic problems. Researchers will give single and multiple oral doses to about 112 participants, some receiving a…

This master protocol supports several early-phase studies testing different amyloid-targeting drugs in healthy volunteers and people with Alzheimer's disease. The main goals are to check safety and tolerability, and to see whether these drugs can remove amyloid plaques from the b…

This early-stage trial evaluates the safety and tolerability of an experimental drug called LY4405094 in healthy volunteers and people with Alzheimer's disease. Researchers will measure how much of the drug enters the bloodstream and the fluid around the brain, and in Alzheimer's…

This first-in-human study will test a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. The study includes 28 people: healthy volunteers and patients with recurrent high-grade glioma or brain metastases from ot…

This study tests whether the drug Qsymia, combined with lifestyle coaching, can prevent obesity in 140 adolescents and young adults (ages 18-25) who are overweight (BMI 25-30) and have a family history of obesity. Participants will receive either Qsymia or a placebo, plus coachin…

This Phase 2 trial tests whether a single dose of (2R,6R)-hydroxynorketamine (HNK), a non-addictive ketamine metabolite, can reduce acute pain in 92 healthy adults. Participants receive either HNK or a placebo intravenously and undergo pain tests, brain scans, and safety monitori…

Researchers are testing an experimental intravenous sedative called KL0011034 in healthy Chinese adults aged 18 to 45. The trial compares continuous infusions of KL0011034 with propofol, a standard sedative, over 1, 2, and 3 hours. Participants are randomly assigned and neither t…

This early-stage study tests whether a liquid containing exosomes—tiny particles released by cells—is safe when applied to the skin of 10 healthy adults. Participants receive the exosome liquid on one small skin area and a plain liquid on another for comparison. The goal is to ch…

This early-stage trial tests an experimental tablet called Alpha-0261 in people with chronic spontaneous urticaria (long-lasting hives) and in healthy volunteers. The study checks the drug's safety, how the body processes it, and whether it reduces hive activity and itching. Part…

This early-stage study will test whether a liquid form of metformin causes fewer stomach problems than the standard tablet. Twenty-four healthy adults will each try both the liquid and tablet versions in a random order. The goal is to see which is better tolerated, which could ev…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

Researchers are studying how the nervous system adapts when healthy adults strengthen their calf muscles. Twenty-two participants aged 18 to 40 complete a four-week resistance training program for the triceps surae, the main calf muscle group. Before and after training, researche…

Researchers are testing whether a contrast dye called gadobutrol, injected into the fluid around the brain and spinal cord, can safely improve MRI images of how that fluid flows. Healthy volunteers aged 18 and older will receive the dye and undergo several brain scans over a week…

Researchers are running a first-in-human trial of NNC0642-1895, an experimental medicine given as a single intravenous dose. The study enrolls about 148 healthy adults aged 18 to 55 with a body mass index between 18.5 and 29.9. Participants receive either the drug or a placebo, a…

Researchers are testing how the body absorbs three different forms of abemaciclib, a drug used to treat some breast cancers. Fifteen healthy volunteers take each form in turn: a current tablet, a new tablet, and oral granules. The study measures how much and how quickly the drug …

Researchers are testing a new tablet form of the experimental drug TRTL-729 in about 10 healthy adults aged 18 to 55. Participants receive a single dose, and the team tracks side effects, vital signs, lab results, heart rhythm, and mood-related safety checks. Blood samples measur…

Researchers are testing an inhaled dry powder called ICF001 in healthy adults aged 18 to 55. The study gives single and repeated doses to see if the drug is safe, how well people tolerate it, and how it moves through the body. Participants receive either ICF001 or a placebo, and …

This phase 1 trial evaluates the safety and tolerability of an experimental oral drug called LY5625575 in healthy volunteers, including Japanese and Chinese participants, and in people with elevated C-reactive protein, a marker of inflammation. Researchers will also measure how m…

This Phase 1 trial in 21 healthy adults compares a new formulation of HBW-3220 capsules with the previous version. Each participant receives a single 120 mg dose under three conditions: old formulation fasting, new formulation fasting, and new formulation after a high-fat meal. R…

This study tests whether the experimental drug olomorasib enters the bloodstream the same way when swallowed as a whole capsule or mixed into water. Healthy volunteers will receive the drug in both forms during a 7-night stay at a research unit. Researchers will measure how much …

This Phase 1 study in China gives a single oral dose of a radiolabeled experimental drug, [14C] CMS-D002, to healthy adults aged 18-45. Researchers will measure how much of the drug is recovered in urine and feces, how it moves through the blood, and what breakdown products it fo…

This early-stage trial is testing a new drug called ZL-1503 in healthy volunteers. The goal is to understand how the drug moves through the body, how safe it is, and how well people tolerate it after a single injection under the skin or into a vein. The study involves 36 healthy …

This pilot study tests whether a daily fermented papaya supplement can improve skin barrier function in healthy adults aged 50 to 75. The main focus is on reducing water loss from the skin on the face, arms, and hands, measured with a non-invasive device. Participants take the su…

This study explores whether voluntary fast, deep breathing (hyperventilation) alters how healthy adults perceive their own body. Participants wear a virtual-reality headset and see a virtual body, with a glowing halo pulsing either in sync with their breathing or out of sync. The…

This early-stage trial is testing an investigational drug called INS1033, given as an oral solution, to see if it is safe and well-tolerated in healthy adults. Participants receive either single or multiple rising doses of the drug or a placebo, and researchers monitor for side e…

This early-phase trial in healthy adults asks whether the experimental oral drug E2086 changes how the body processes several common medications, including an antifungal, a seizure drug, a sedative, a cough suppressant, an antidepressant, and birth control pills. Participants rec…

This study tests a new way to deliver two common Parkinson's medications, carbidopa and levodopa, using a small pouch placed between the cheek and gum. The pouch releases the drugs slowly, allowing absorption through both the cheek lining and the stomach. Researchers are measurin…

This Phase 1 trial in about 18 healthy adults tests whether taking NTQ5082 capsules changes how the body processes midazolam, a short-acting sedative used as a probe to measure liver enzyme activity. Participants receive midazolam alone and then alongside single and repeated dose…

This study compares two ways of giving the same experimental biosimilar drug, DRL_AB, which is designed to work like abatacept for autoimmune conditions. Healthy male volunteers receive a single dose either through an autoinjector or a prefilled syringe. Researchers measure how m…

This phase 1 trial tests whether an inhaled experimental drug called ICF004 is safe and how the body processes it. Healthy Chinese adults aged 18 to 50 will breathe in either a single or multiple doses of ICF004 or a placebo via a dry powder inhaler. The study aims to identify an…

This study looks at whether a hands-on ankle technique called mobilization with movement can immediately improve how high healthy university students can jump and how far they can bend their ankle. Half the participants receive the real mobilization, while the other half get a sh…

This early-stage trial tests the safety and how the body handles VV261 tablets in healthy Chinese adults aged 18 to 45. Participants receive either VV261 or a placebo multiple times daily. Researchers measure drug levels in the blood and monitor for any side effects. The goal is …

This study tests whether pressing on the abdomen with an ultrasound probe can temporarily stop blood flow in the main artery (aorta) in healthy adults aged 18-40. The goal is to see if this technique is effective and tolerable, potentially offering a more accurate way to control …

This phase 1 trial tests an experimental drug called BMS-986368 in 16 healthy Chinese adults. The main goal is to measure how the drug moves through the body and to check for any side effects. Participants receive either the drug or a placebo, and researchers monitor safety throu…

This study investigates whether one year of boxing training can improve attention in adolescent athletes aged 13-15. Researchers will use the Attention Network Test to measure changes in alerting, orienting, and executive control. The goal is to understand how boxing affects brai…

This study collects data from 50 healthy adults who wear both a wrist device and a chest ECG patch for 24 hours. The goal is to train artificial intelligence to reconstruct detailed heart signals—especially the QT interval—from the wrist's light-based pulse readings. If the AI wo…

This study looks at whether pantoprazole, a common heartburn medication, changes how the body processes an experimental drug called CHF10196. Healthy male volunteers receive CHF10196 alone and then again after taking pantoprazole. Researchers measure drug levels in the blood to c…

This study checks whether Kinovea, a free video analysis software, can consistently measure knee and hip angles when people stand up from a chair. Healthy volunteers aged 18 to 45 will be recorded doing sit-to-stand movements, and three physiotherapists will analyze the videos se…

This study explores how focused ultrasound can change brain activity in healthy adults. Researchers will send sound waves through the skull to the visual and hearing parts of the brain to see what people perceive. The goal is to find the best settings for future treatments of con…

This study will test whether a small injection of lidocaine around the radial artery in the wrist can temporarily reduce sympathetic nerve activity in 20 healthy volunteers. Researchers will measure blood flow and hand temperature before and after the injection, using cold water …

This study looks at how two types of fasting—Ramadan dry fasting (no food or water from dawn to sunset) and 16:8 time-restricted feeding (water allowed)—affect the cleanup and renewal of mitochondria, the energy factories in your cells. Researchers will track blood markers in 120…

This study looks at how brief periods of low oxygen (intermittent hypoxia) affect a measure called 'loop gain,' which reflects how your body controls breathing. Researchers want to understand if these oxygen dips can make breathing control less stable, which may help explain slee…

This study looks at whether an 8-week dairy drink with extra protein, calcium, and vitamin D can help physically active adults aged 18-39. About 50 volunteers will drink the product and take tests on strength, body composition, and how they feel. The goal is to see if the drink i…

This study tests a new set of free audio exercises designed to make mindfulness research more inclusive. The exercises are written at a 5th-6th grade reading level and don't require a teacher or quiet space. 360 healthy adults will listen to one 12-minute audio and answer questio…

This early-stage study looks at how food and ethnic background affect the way a new drug, JPI-547, moves through the body. It involves 36 healthy men of Korean, Caucasian, or Chinese descent who take a single dose. The goal is to gather safety and drug-level data, not to treat an…

This study looks at how long heart rate recordings should be to best detect changes from a mild nerve stimulation in the ear. Forty healthy adults will receive both real and fake stimulation in random order. Researchers will compare 1-minute, 5-minute, and 10-minute recordings to…

This study will test how stimulating the ear with mild electrical pulses at different frequencies affects heart rate, breathing, and blood pressure in 36 healthy adults. Each person will try five different stimulation settings (including a fake one) in separate sessions. The goal…

This study will test whether stimulating the vagus nerve through the ear for 5, 10, or 15 minutes changes heart rate, blood pressure, and other body signals in healthy adults. Forty-four participants will receive either real or sham stimulation in random order. The goal is to see…

This study tests whether real-time fMRI can alter how healthy people perceive social interactions. Ten participants will undergo multiple MRI sessions where their brain activity is monitored and used to trigger specific trials. The goal is to see if this feedback can shift their …

This study explores whether different vibration frequencies from a smartphone can temporarily improve hand grip strength, touch sensitivity, and reaction time in healthy young adults. Twenty participants will hold an iPhone running a custom app that delivers vibrations at 80, 150…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This early-stage study tests the safety of a new drug called HS-20152 in 32 healthy adults aged 18 to 64. The drug targets the complement system, part of the body's immune response. Researchers will monitor for side effects and measure how the drug moves through the body. This st…

This study looks at how the design of breathing masks affects breathing in 10 healthy volunteers. Participants will try four different masks while using a breathing machine. The goal is to see if mask design changes breathing patterns, carbon dioxide levels, and breathing rate. T…

This study looks at how different phases of the menstrual cycle relate to muscle strength and physical performance in healthy, active women aged 18 to 35. Participants will track their cycle with a phone app and attend three lab visits for strength tests and body measurements. Th…

This early-stage study tests the safety and tolerability of a new oral drug called ISM4808 in 86 healthy adults aged 18-55 in China. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to…

This study tests a new computer method (HDC) to recognize hand gestures using muscle sensors on the forearm. Ten healthy volunteers will perform gestures while wearing a sensor armband. The goal is to see if the new method is more accurate than standard approaches. This is a tech…

This study compares two drugs, IN-M00007 and IN-R00007, to see if they are equivalent in healthy adults aged 19 to 59. Sixty volunteers will take a single dose of each drug in random order, and researchers will measure how the drugs are absorbed and how safe they are. The goal is…

This early-stage trial will give 24 healthy adults a single dose of Hezkue oral sildenafil suspension after they drink a moderate amount of alcohol. Researchers will measure how the drug moves through the body and how quickly it starts working. The goal is to understand any effec…

This early-stage study will test how two different liquid forms of metformin affect blood sugar compared to regular metformin tablets. Twenty-four healthy adults will take short-term doses and have their blood glucose measured. The goal is to see if the liquid versions work diffe…

This study tests how stimulating the vagus nerve at different frequencies affects heart rate, blood pressure, and breathing in 36 healthy adults. Participants will receive five different stimulation frequencies (including a sham) in random order. The goal is to find which frequen…

This study will test a new markerless motion capture system that uses only four cameras to analyze how children walk. Researchers will enroll 125 healthy children aged 6 to 17. The goal is to see if this simpler setup can provide useful information about walking patterns, which c…

This study tests whether doing sit-to-stand exercises with a blood flow restriction cuff on the thigh can improve back muscle endurance and balance more than the same exercises without the cuff. Seventy healthy young adults aged 20-25 will exercise twice a week for six weeks. Res…