HEALTHY VOLUNTEERS

This study aims to monitor the safety of a high-dose flu vaccine (Efluelda®) in adults aged 65 and older in South Korea. Researchers will track any side effects or reactions that occur in the month following vaccination. The goal is to gather real-world safety information after t…

This is an early-stage safety study testing a new oral medication called RO7795081 for weight management. It will enroll 30 otherwise healthy Chinese adults who have obesity or are overweight. The main goal is to check how safe the drug is, how the body processes it, and what sid…

This early-stage study is testing a new formulation of an important antibiotic called polymyxin B. The goal is to see if this new version, called VRP-034, is less damaging to the kidneys than the standard version, while still being effective. The study will involve 48 healthy adu…

This study is testing whether a new drug called JUV-161 can help prevent muscle loss when a person's leg is immobilized, like after an injury. Healthy volunteers aged 40-65 will have one leg put in a brace for two weeks and receive weekly injections of either the drug or a placeb…

This study aims to prevent obesity in young adults (ages 18-25) who are overweight and have a family history of obesity. Researchers will test if combining personalized lifestyle coaching with a low-dose weight management medication (Qsymia) is more effective than coaching alone …

This study is testing if adding a special cuff that partially restricts blood flow to the legs during simple sit-to-stand exercises can improve back muscle endurance and balance better than doing the same exercises without the cuff. Healthy young adults aged 20-25 will be randoml…

This study is testing whether a single dose of an experimental drug called (2R,6R)-HNK can relieve short-term pain in healthy adults. Researchers want to find pain relief options that aren't addictive like opioid medications. The study involves 92 healthy volunteers who will rece…

This early-stage study aims to understand how drinking alcohol affects a new liquid form of sildenafil (Hezkue®). Researchers will give the medication to 24 healthy adults after they consume a moderate amount of alcohol. They will measure how much of the drug gets into the bloods…

This early-stage study aims to understand how the experimental drug CS0159 is processed by the body. Researchers will test it in 32 healthy volunteers to see if taking it with a high-fat meal changes its effects, and how it interacts with two other common medications. The goal is…

This study aims to test the safety of a new form of magnetic brain stimulation called high-density theta burst stimulation (hdTBS) in healthy adults. Researchers will compare its aftereffects to an older, FDA-approved version. The goal is to gather basic safety information and se…

This is an early-stage study to check the safety and basic effects of a new oral compound called SEP-479 in healthy adults. Researchers will give different doses to about 150 participants to see how the body processes the drug and whether it causes any side effects. The study wil…

This early-stage study aims to understand how two new liquid forms of the diabetes medication metformin affect blood sugar levels in healthy adults, compared to the standard pill. Researchers will give 24 healthy volunteers single or short-term doses of the different formulations…

This early-stage study aims to understand how a new drug called BMS-986435 is processed by the body in people with normal liver function and those with mild to moderate liver impairment. The study will enroll 24 participants to measure drug levels in the blood and monitor for saf…

This study aims to see if a single dose of a nutritional supplement called nicotinamide riboside (NR) has any immediate effect on sleep. Researchers will monitor 20 healthy adults who report mild sleep issues during two overnight lab stays. They will compare sleep patterns after …

This is an early safety study for a new injection called KL0011034. It will test different doses in 76 healthy volunteers to see how safe it is and how the body processes it. The main goal is to gather initial information, not to treat any disease.

This study is testing whether new liquid versions of the diabetes medication metformin cause fewer stomach problems than the standard pill form. Researchers will give 24 healthy adults single doses of either liquid or pill metformin and track any side effects. The goal is to see …

This study aims to test a new computer algorithm designed to better recognize hand gestures from muscle signals. Researchers will compare their new method to existing ones to see which is more accurate and faster. The goal is to improve technology for future applications like adv…

This study aims to understand how thinking patterns differ in people with idiopathic environmental intolerance (IEI), a condition where individuals experience symptoms they attribute to environmental factors like chemicals or electromagnetic fields, despite no identifiable medica…

This is an early-stage study to see if a new drug called B-3E07 acts similarly to the existing osteoporosis drug Forsteo in the body. It will involve 48 healthy adult women who will receive both drugs in a random order. The main goal is to compare how the body absorbs and process…

This is the first human study of an experimental drug called GenSci161. Researchers will give 44 healthy adults a single injection to test its safety and see how the body processes it. The study will start with low doses and carefully monitor participants for any side effects bef…

This study aims to understand how a targeted nerve block near the wrist affects blood flow and temperature in the hands of healthy volunteers. Researchers will measure changes in finger blood flow and skin temperature before and after the block, especially when hands are exposed …

This study aims to understand how carbamazepine, a common epilepsy medication, affects how the body processes an experimental cancer drug called mirdametinib. Researchers will give both drugs to 36 healthy volunteers and measure the drug levels in their blood over time. The goal …

This study is testing three new types of digital inhaler devices to see how well they work and how comfortable they are to use. Ten healthy volunteers will try all three devices, which deliver a harmless saltwater mist. The main goal is to collect engineering data on airflow and …

This is the first study in humans for a new drug called RO7875913. It will be given to 40 healthy volunteers to check its safety, see how the body processes it, and find a safe dose for future studies. The goal is to gather information, not to treat any disease.

This study aims to understand how different mask designs used with breathing support machines affect breathing patterns in healthy people. Ten volunteers will try four different masks while their breathing is monitored. The goal is to gather information that could help improve ma…

This is an early safety study of an experimental drug called migaldendranib (MGB) in healthy volunteers. Researchers will give increasing weekly doses to up to 36 healthy adults to check for side effects and see how the drug is processed by the body. The goal is to gather basic s…

This is the first study in people to test the safety of a new tablet called KMY. It will involve 120 healthy volunteers to see how the body handles the drug and if it causes any side effects. The study will test single doses, multiple doses, and whether food affects how the drug …

This study aims to test a Turkish version of a questionnaire that measures 'cybersickness'—the nausea and disorientation some people feel in virtual reality. Researchers will enroll 42 healthy volunteers to see if the translated survey is accurate and reliable. The goal is to cre…

This study aims to understand if a dietary supplement called TRPTI can change gut bacteria and improve blood markers related to insulin sensitivity in healthy adults. Researchers will compare two different doses of TRPTI against a placebo pill over four weeks. The main goal is to…

This study aims to understand how stimulating a nerve in the ear at different speeds affects basic body functions like heart rate, blood pressure, and breathing. Healthy volunteers will receive five different stimulation settings in a random order, with their body's responses car…

This is a very early study to check if a new oral drug called ISM4808 is safe for people and to see how the body processes it. It will involve 86 healthy adults in China who will receive either the drug or a placebo. The main goal is to find the safest dose and understand how the…

This early-stage study aims to understand if the hormone progesterone changes how women's muscles build protein after strength training. Researchers will compare a progesterone pill to a placebo in 20 healthy premenopausal women. Participants will do leg exercises, receive an inf…

This early study is testing a new radioactive tracer called MeFAMP for PET scans to see if it can safely and clearly show brain tumors. It will first check safety in healthy volunteers, then test the tracer in patients with recurrent high-grade glioma or brain metastases from oth…

This is the first study to test the experimental drug AKB-9090 in humans. It aims to check if the drug is safe and how the body processes it in 70 healthy adult volunteers. Researchers will give different doses and measure drug levels and effects on markers related to red blood c…

This study aims to understand if a supplement called TRPTI (oleoylethanolamide) can improve how healthy adults process sugar after a meal. Researchers will test two different doses against a placebo in 20 healthy volunteers to see if it lowers blood sugar spikes and improves insu…

This is a first-in-human study to check the safety and see how the body absorbs and eliminates a new capsule called VV913. It will involve 56 healthy male volunteers who will receive a single dose of either the capsule or a placebo. The main goal is to understand how safe the cap…

This study aims to create a reference standard for a new, simpler way to analyze how children walk. Researchers will use a system with just four cameras to record the walking patterns of 125 healthy children. The goal is to later use this reference to better understand and treat …

This is the first study testing a new drug called ME3241 in humans. Researchers will give the drug to healthy volunteers to check if it's safe and to see how the body processes it. The study will compare people who receive the drug to those who receive a placebo (inactive substan…

This study aims to understand how brief periods of low oxygen affect the body's automatic breathing control system. Researchers will expose 40 healthy volunteers to controlled low-oxygen air for six hours and measure changes in their breathing patterns. The goal is to learn more …

This study aims to understand how different phases of a woman's menstrual cycle affect physical performance, muscle strength, and body composition. Researchers will track 32 physically active women aged 18-35 for about two months, having them use a mobile app to monitor their cyc…

This early-stage study aims to see how a new drug called repinatrabit interacts with several common medications, including birth control, diabetes, and cholesterol drugs. It will involve 48 healthy volunteers to measure drug levels in the blood and check for safety. The goal is t…

This study aims to see if two different versions of a cholesterol-lowering drug combination are absorbed by the body in the same way. It will involve 60 healthy adult volunteers who will take each version once. The main goal is to compare the drug levels in the blood and check fo…