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Scientists zap vagus nerve to find the perfect frequency for heart and lung health

NCT ID NCT07274332

Knowledge-focused Sponsor: SEFA HAKTAN HATIK Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests how stimulating the vagus nerve at different frequencies affects heart rate, blood pressure, and breathing in 36 healthy adults. Participants will receive five different stimulation frequencies (including a sham) in random order. The goal is to find which frequency produces the strongest effects on the autonomic nervous system.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous cervical vagus nerve stimulation (tcVNS) via Pulsetto FIT™ device
What this could lead to
If it works, this could help identify the best stimulation frequency for future treatments targeting the autonomic nervous system.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions. The effects are short-term and may not lead to lasting benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-30 years * Healthy (self-reported) * No cardiovascular, neurological, metabolic or psychiatric disorders * No regular medication affecting autonomic function * Non-smoker * BMI 18-29.9 Exclusion Criteria: * Pregnancy * Cardiac arrhythmia * Hypertension or hypotension * Chronic respiratory disorders * Active infection * Metal implants in cervical area * Epilepsy * Syncope history * Prior vagus stimulation experience

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Conditions

The condition(s) this trial relates to.

autonomic nervous system disorder hypertensive disorder Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autonomic nervous system Blood pressure Healthy volunteers Heart rate Respiration Vagus nerve stimulation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sinop University, Türkeli Vocational School (Türkeli MYO)

    Türkeli, Sinop, 57900, Turkey (Türkiye)

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