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Your genes may determine how well ibuprofen works for tooth pain

NCT ID NCT05983042

Knowledge-focused Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study in 200 healthy Pakistani adults looked at whether a common gene variation (CYP2C9*3) changes how well ibuprofen works for pain after a molar tooth extraction. Participants took ibuprofen or a placebo, and researchers measured pain levels and side effects. The goal was to see if genetics could help predict who gets the best pain relief with the fewest side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ibuprofen 400 mg
What this could lead to
If successful, this could help doctors personalize painkiller choices based on a person's genetics, improving pain relief and reducing side effects.
What could go wrong
This is a small, completed observational study in a specific population, so results may not apply to other groups. It does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

200 people

The number who actually took part.

Started

Nov 2022

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals who were advised for molar tooth extractions based on orthodontic, periodontal, and endodontic indications

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pakistani individuals * Absence of systemic diseases * Extractions required based on orthodontic, periodontal, and endodontic indications Exclusion Criteria: * history of bleeding or gastrointestinal ulcers * allergic to ibuprofen or other NSAIDs. * Pregnancy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers

Contacts and locations

Locations

  • Ammarah Amjad

    Rawalpindi, Punjab Province, 46000, Pakistan

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