HEALTHY VOLUNTEERS

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and boosts the body's immune response against COVID-19. Participants receive one injection, and researchers monitor for side effects and measure…

This study tests a new drug called JUV-161 in healthy volunteers aged 40 to 65 who will have one leg immobilized for several weeks. The goal is to see if the drug can prevent muscle loss and is safe. Participants receive weekly injections of either JUV-161 or a placebo for about …

This early-stage study tests an experimental drug called ALN-PNP in healthy adults and people with a type of fatty liver disease (MASLD) who have a specific gene variant. The main goal is to check safety and how the body processes the drug. Researchers will also measure changes i…

This early-stage study tests an experimental oral drug, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not yet to prove weight loss. Participants are randomly assigned to recei…

This early-stage study tests a new medicine called BMS-986470 in about 184 people, including healthy volunteers and those with sickle cell disease. The main goal is to check safety and find the right dose, while also looking at how the drug works in the body and its early effects…

This early-stage study tests a new medicine called NNC0581-0001 in 48 adults with fatty liver and possible liver inflammation. Participants receive either the drug or a placebo as a monthly injection for 3 months. The main goal is to check safety and how the body processes the dr…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect neuroendocrine tumors. About 200 healthy volunteers and people with neuroendocrine tumors will receive a radioactive tracer and be scanned with a high-sensitivity PET m…

This study tests a new PET scan method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. About 200 adults, including healthy volunteers and those with memory problems, will receive a standard radioactive tracer and be s…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. About 2,195 healthy infants will receive four doses of either the new vaccine or a currently licensed vaccine st…

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend multiple sessions ove…

This early-stage study tests a new drug called ABCL635 for moderate-to-severe hot flashes in postmenopausal women. It will also include healthy volunteers to check safety. The goal is to see if the drug reduces how often and how bad hot flashes are, and to find the right dose.

This study tests whether a 12-week program combining modern dance with mindfulness exercises can improve psychological well-being, reduce stress, and increase happiness in recreational adult dancers. About 160 adults who already take dance classes will be randomly assigned to eit…

This study is checking if mulberry leaf extract capsules are safe for healthy volunteers and if they help control blood sugar. About 48 adults without diabetes will take either the extract or a placebo three times a day for 8 weeks. Researchers will monitor blood tests and any si…

This study looks at how the brain decides whether to work hard for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans to see which brain connections matter for motivation. The goal is to understand apathy in brain disorders and find ways to boost …

This study is testing a new device that uses light to measure pulse waves and estimate blood pressure. Researchers will compare it to standard equipment in 27 healthy adults. The goal is to see if this method is reliable and could lead to simpler blood pressure monitoring.

This early-stage study checks how safe three experimental drugs (DWJ1622, DWC202313, DWC202314) are and how they move through the body after a meal. It involves 36 healthy adults who will receive the drugs in a random order. The goal is to gather basic safety and processing infor…

This early-stage study tests whether a new drug, RBD1119, is safe in healthy adults. About 32 participants will receive either the drug or a placebo as a single shot under the skin. The main goal is to check for side effects and measure how the drug moves through the body.

This study is a planning step for future clinical trials. It involves 150 healthy volunteers, people with Parkinson's disease, and those with paralysis. Researchers will test brain and heart monitoring methods like MEG, MRI, EEG, and ECG to make sure they work well for upcoming s…

This study aims to create a large registry of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples to see how these tiny organisms differ from person to person based on factors like diet, medications, and where the…

This study looks at how your internal body clock changes the way you perceive time, think, and feel when you stay awake for 36 hours. Thirty healthy adults aged 23 to 45 will stay in a controlled lab, awake the whole time, with constant light, posture, food, and activity. Every t…

This study uses brain scans (fMRI and EEG) to understand how healthy people process social information like empathy and reading others' thoughts. Researchers will look at brain activity and structure in 200 healthy adults, and see if these patterns change with age. The goal is to…

This study is the first time AKB-9090 is being tested in humans. It aims to check the drug's safety and how the body processes it in about 70 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the need for radiation or invasive tests. Researchers will compare new MRI methods with standard angiography in up to 4,000 adults, including healthy volunteers and those with or at…

This early-stage study gives a single dose of a radioactive form of the experimental drug E2086 to 10 healthy men. Researchers measure how much of the drug appears in blood, urine, and stool to understand how the body absorbs, breaks down, and eliminates it. The goal is purely to…

This study aims to create a large collection of medical images (MRI and ultrasound) of the heart, liver, and blood vessels from 2,400 healthy volunteers across France. By analyzing these images alongside factors like age and sex, researchers hope to establish what 'normal' looks …

This study looks at how a person's background—like race or ethnicity—affects how they feel and show pain, and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test if people can learn to assess pain more accurately. The goal is to…

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. It involves 42 participants and is only for research, not treatment. The goal is to understand drug interactions for future use.

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The main goal is to see how RAD301 moves through the body and how much radiation reaches orga…

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tasks and brain imaging. The goal is to learn more about normal brain function, which can help f…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, but to gather important safety inf…

This early-stage study tests the safety and tolerability of a new drug called HW241045 in 56 healthy adults. Participants receive a single dose of the drug or a placebo, and researchers monitor for side effects. The goal is to gather initial safety data before testing the drug in…

This study aims to define normal test results for spatial neglect, a common attention disorder after stroke. Researchers will recruit 210 healthy French-speaking adults aged 20-89 to take simple paper-and-pencil tests. The results will help doctors better diagnose spatial neglect…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with cancer or blood disorders, as well as from healthy family members who are stem cell donors. The samples are used in lab research to understand diseases better, improve current treatment…

This study tests whether the experimental drug BMS-986278 affects the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and a positive control in random order. The goal is to gather safety data, not to treat any disease.

This early-stage study is testing a new drug called RO7806881 in 128 healthy adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather safety information before testi…

This study looks at whether a specific chest massage technique, called intercostal mobilization, can make breathing easier and improve walking performance. Researchers will compare three groups of healthy, sedentary adults aged 18-30: one receiving the massage, one receiving a fa…

This study aims to find better ways to measure what people eat, specifically sugar, without relying on self-reporting. Researchers will give 60 healthy adults different amounts of sugar in their diets and then check if stable isotopes in blood, hair, and other samples can accurat…

This study looks at whether emergency medicine doctors can get clear ultrasound images of the belly wall muscles needed for a pain-block procedure called a TAP block. Researchers will test this in 118 adult volunteers of different body sizes. No medications are given—just an ultr…

This study looks at how taking VV119 with or without a standard meal changes the way the body processes the drug. It involves 16 healthy Chinese volunteers who will take a single dose of VV119 under different conditions. The goal is to measure side effects and drug levels in the …

This study aims to improve how MRI scans are done to get clearer pictures of the body. It involves 1,000 healthy adults and current NIH participants who will have one or more MRI scans over a few years. The goal is to develop better scanning techniques, not to treat any disease.

This early-phase study tests a single dose of VV261 tablets in 58 healthy adults aged 18-45 to check safety and how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo. The goal is to gather information, not to treat any dis…

This early-stage study tests whether the drug TAK-781 is safe and tolerable. It first gives single or multiple doses to healthy volunteers, then a single dose to people with non-cirrhotic primary sclerosing cholangitis (PSC). The goal is to check for side effects and how the body…

This study checks whether a single dose of balinatunfib changes the heart's electrical activity in 44 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and another heart-affecting drug in random order to compare effects. The goal is safety data, not treatmen…

This study looks at how people use hearing versus physical sensation when they speak. Healthy adults aged 18 to 45 will complete speech tasks where their hearing is altered through headphones, sometimes with a visual display of their speech. A computer model will estimate each pe…

This study aims to measure how much of the medication KarXT passes into breast milk when taken by healthy nursing mothers. Researchers will enroll 8 participants who are exclusively pumping milk to carefully track medication levels in both milk and blood. The goal is to understan…

This study aims to understand how genes and the environment shape children's eating behavior and health over time. Researchers will follow 1,500 children ages 8-17 for up to 6 years, using wrist monitors, smartphone surveys, and yearly checkups that include blood tests, X-rays, a…

This study collects blood, urine, saliva, and tumor tissue from people with or at risk for urothelial cancer, as well as from healthy volunteers. The goal is to analyze DNA and other molecular changes to learn what causes this cancer and how it responds to treatment. Participants…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study aims to understand how sleep improves visual learning. Researchers will use MRI and sleep monitoring to watch brain activity while participants sleep. Ten healthy adults aged 18-30 will take part. The goal is to learn more about the brain's processes, not to test a tre…

This study looks at whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how healthy people feel overall. It involves 120 healthy Chinese adults who don't eat many fruits and vegetables. Participants will take either the supplements or a placebo…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, and researchers will monitor side effects and drug levels in the blood. The study do…

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) can help trained athletes get more out of high-intensity interval training (HIIT). Thirty healthy, fit adults aged 18-35 will do an 8-week cycling HIIT program, with half also getting …

This study is an early test of a new medicine called RO7763505. It will check if the drug is safe and how the body processes it. The trial includes about 196 people, first healthy volunteers and then patients with stable coronary artery disease. Participants will receive either t…

This study is for healthy adults to see how different tablet versions of the drug BMS-986435 are absorbed by the body. It also checks if food changes how the drug works. About 140 participants will take part, and the goal is to gather information, not to treat any disease.

This study aims to measure how quickly proteins in the body are replaced (protein turnover) in healthy adults of different ages. Participants will drink small amounts of safe heavy water for 21 days and undergo tests including muscle and fat biopsies, imaging scans, and strength …

This study tests a new device called pneuRIP that measures breathing without touching the body. It uses special bands placed around the chest and belly. The study will include 10 healthy children and 10 children with mild breathing problems from muscle diseases. Researchers want …

This early-stage study tests whether a new drug, ZP9830, is safe and tolerable in healthy volunteers aged 18-45. About 124 participants will receive either the drug or a placebo to see how the body processes it. The goal is to gather safety information, not to treat any disease.

This early-stage study is testing the safety of a new drug called ARGX-124 in healthy adults. Researchers will also measure how the drug moves through the body and how the immune system reacts. About 104 healthy volunteers aged 18 to 65 will take part, and the study lasts up to 2…

This early-stage study tests the safety and psychological effects of combining psilocybin (a psychedelic compound) with D-serine in 10 healthy adults aged 25-60. Participants receive one of two dose levels to see if D-serine can reduce the psychedelic experience. The goal is to g…

This study looks at how taking a new medicine (ZN-A-1041) with food or with a common stomach-acid drug (rabeprazole) changes the amount of medicine in the blood. About 48 healthy adults will take the medicine under different conditions to measure absorption. The results will help…

This study looks at whether sucralose, a common artificial sweetener, changes how the body absorbs and processes certain medicines. Researchers will give healthy overweight Hispanic and Black women either sucralose or a placebo for four weeks and measure drug levels, hormone chan…

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD), a condition that causes lung scarring. The goal is to measure how the drug moves through the body and check for safety, not to treat the diseas…

This early-stage study is testing the safety and how the body handles three experimental drugs (DWJ1622, DWC202313, DWC202314) in 40 healthy adults. Participants take the drugs under fasting conditions and are monitored closely. The goal is to gather basic safety and drug-level i…

This early-stage study is testing a new drug, SEP-479, in 150 healthy adults aged 21 to 60. The main goal is to see if the drug is safe and how the body processes it. Participants will take single or multiple doses, and researchers will monitor side effects and drug levels in the…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep tests, and blood work to compare four groups: people who recently had suicidal thoughts or attempts, those with past thoughts, people wit…

This study tests a new non-invasive method called temporal interference (TI) to stimulate deep brain regions using harmless electrical currents. Researchers will scan the brains of 30 healthy adults aged 18-50 to see if TI can safely activate deep areas without affecting the oute…