HEALTHY VOLUNTEERS

This Phase 3 study is testing an investigational meningococcal conjugate vaccine (MenACYW) in over 1,600 healthy children and adolescents aged 2 to 17 in China. The vaccine aims to protect against four types of meningococcal bacteria that can cause serious infections like meningi…

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu caused by the H5 virus. Healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a …

This early-stage study tests a new vaccine called VXB-241 in healthy adults aged 60-83, with a smaller group of younger adults (18-40) first. The vaccine is designed to protect against two viruses that can cause serious lung infections: RSV and HMPV. Researchers will check how sa…

This study tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and can boost the body's defenses against multiple coronavirus variants. Participants receive one injection and are monitored for side effects and immune re…

This study tests a new vaccine that aims to protect against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and sepsis. It involves 750 healthy children, toddlers, and infants in three stages, comparing the new vaccine to existing licensed vaccines. The…

This study tests a new 21-valent pneumococcal conjugate vaccine (PCV21) in about 1,092 healthy infants and toddlers. The goal is to see if PCV21 is safe and helps the body produce antibodies against pneumococcal bacteria better than the current licensed vaccine. Participants rece…

This early-stage trial is testing a new drug called KK4277 to see if it is safe for people with lupus. The study first gives a single dose to healthy volunteers, then multiple doses to patients with systemic lupus erythematosus (SLE) or cutaneous lupus erythematosus (CLE). Resear…

This early-stage study tests a new drug called CMP-CPS-001 in healthy adults and women who carry a gene for OTC deficiency, a rare liver condition that can cause dangerous ammonia buildup. The main goal is to check the drug's safety and how the body processes it. Participants rec…

This study tests an experimental drug called MRT-8102 for the first time in humans. It includes healthy volunteers and people with high inflammation (elevated CRP) who are at risk for heart problems. The goal is to check the drug's safety and find the right dose for future studie…

This early-stage trial is testing a new drug called VSA012 for the first time in humans. The goal is simply to see if it is safe and how the body handles it. Forty healthy volunteers will receive either a single dose of VSA012 or a placebo. The results will help decide if VSA012 …

This early-stage study tests a single dose of ABBV-277 in 32 healthy adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo by IV infusion. The goal is to measure side effects and drug levels in the blood, not to treat any illne…

This study looks at how the bacteria living in your gut might change the way your body responds to rosuvastatin, a drug used to lower cholesterol. Researchers will give healthy volunteers either the drug or a placebo for eight weeks and track changes in gut bacteria and cholester…

This early-stage trial compares a new drug called IBI3027 to the approved medication Dupixent. It involves 180 healthy Chinese men who receive a single injection of either drug. The goal is to see if IBI3027 is absorbed and cleared from the body similarly to Dupixent, and to chec…

This early-stage study tests whether sirolimus, an FDA-approved drug, can improve blood flow to the brain in healthy adults aged 45-65. Some participants carry a gene (APOE4) that raises Alzheimer's risk, while others do not. The goal is to see if the drug affects brain blood flo…

This Phase 1 trial is the first time ORKA-002 is being tested in humans. It involves 24 healthy adults to check the drug's safety, tolerability, and how the body processes it. Participants receive a single injection of either ORKA-002 or a placebo. The study is not designed to tr…

This study was designed to see how various drugs (like stimulants, painkillers, and sleep aids) affect mood, pain tolerance, and thinking in healthy adults aged 18-55. Participants would have taken blinded oral medications and reported their experiences. However, the study was wi…

This study is creating a large community registry and biorepository with 50,000 adults from Cabarrus County and Kannapolis. Participants provide health information and biological samples to help researchers better understand chronic diseases and improve medicine. It is an observa…

This study uses a special camera (OCT) to take detailed pictures of the eyes of 20 healthy adults. The goal is to improve the camera's software so it can better detect eye diseases in the future. Participants have no eye problems and will not receive any treatment.

This study was designed to test a new breath-activated inhaler (EDDIS) in healthy adults. Participants would have inhaled a tiny amount of radioactive liquid to see how well the device delivers medication to the lungs. The study was withdrawn before any volunteers were enrolled, …

This study looks at how omega-3 fatty acid supplements change the makeup of red blood cells and muscle function in healthy male athletes. Researchers will measure omega-3 levels in blood and use a special device to check muscle responses. The goal is to understand the effects, no…

This study tests a special MRI imaging agent called [13C]pyruvate in 50 healthy volunteers. The goal is to see how this substance moves through and is used by healthy organs. Researchers hope to improve MRI image quality and understand normal metabolism, which could help detect d…

This study follows about 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers collect blood and saliva samples over 6 to 12 months to see when the virus becomes active again and how the immune system responds. No treatments or vaccines a…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This early-stage study tests the safety of a new drug called ABCL575 in 40 healthy adults. Participants receive either a single dose of the drug or a placebo. The goal is to check for side effects and how the body processes the drug, not to treat any disease.

This study collects blood, DNA, and lung tissue samples from 315 people with pulmonary fibrosis, their family members, and healthy volunteers. Researchers will analyze these samples to learn more about what causes the disease. The goal is to better understand the disease mechanis…

This study looks at how a non-invasive brain stimulation technique called TMS affects decision-making in people with opioid use disorder and healthy volunteers. Participants will have MRI scans and play computer games while receiving real or placebo TMS. The goal is to understand…

This study aims to understand the distinct mental states and physical reactions that occur during a psychedelic experience. Up to 12 healthy volunteers with prior psychedelic use will receive four doses of psilocybin (one low and three high) while undergoing MRI and EEG scans. Re…

This study looks at how a new pill that combines three diabetes medicines (gemigliptin, dapagliflozin, and metformin) works in healthy adults. About 58 people will take either the new combination pill or the three drugs separately, then switch. The goal is to see if the combinati…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and non-invasive brain stimulation (TMS)…

This early-stage study tests a single injection of a new drug, RBD1119, in 32 healthy adults aged 18 to 65. The main goal is to check for side effects and see how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo, and no o…

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who do not use tobacco or nicotine products. The goal was to find which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any part…

This study aims to establish normal reference ranges for white blood cells and granulocytes using a new device called the Liberty Analyzer WBC System. About 300 healthy adults aged 21 and older will provide blood samples. The results will help doctors interpret future test result…

This study looks at whether vitamin D levels in blood samples change when the samples are frozen or stored for different lengths of time. Researchers will compare fresh blood samples to stored ones from 80 healthy adults. The goal is to make sure labs can use stored samples witho…

This early-stage study tests the safety of a new drug called JADE101 in 32 healthy adults aged 18 to 55. Participants receive either a single dose of JADE101 or a placebo by injection under the skin. The goal is to see how the body handles the drug and whether it causes any side …

This early-stage study is testing a new drug, SL-325, in 72 healthy volunteers to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease but to gath…

This early-stage study at Stanford University compares ketamine to a placebo (saline) during sedation in 15 healthy adults with major depressive disorder. The goal is to see how these drugs affect brain activity and experiences like dreams or thoughts. Researchers will use EEG to…

This study checks whether a single dose of the experimental drug balinatunfib changes the heart's electrical activity in 48 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and another active drug in random order to compare effects. The goal is to ensure th…

This early-phase study tests the safety of a new drug, budoprutug, in 38 healthy adults aged 18-60. Participants receive either the drug or a placebo by injection or IV. The goal is to check for side effects and how the drug moves through the body, not to treat any disease.