HEALTHY VOLUNTEERS

This early-stage trial tests a new medicine called NNC0581-0001 in 48 adults with fatty liver and suspected liver inflammation. Participants receive monthly injections for three months, either the drug or a placebo. The study lasts about 58 weeks and mainly checks safety and how …

This study tests a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. The goal is to check its safety, how the body processes it, and whether it might help control the disease. About 184 participants will receive either the drug or a placebo in …

This study is testing a new experimental medicine called NNC1679-0001 for type 2 diabetes. It is a very early (phase 1) trial to check if the drug is safe and how the body handles it. About 58 healthy volunteers and people with type 2 diabetes will receive a single injection of e…

This early-stage trial tests an experimental daily pill called RO7795081 in 30 healthy Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body handles it, not yet to prove weight loss. Participants will receive either the drug or a…

This early-phase trial tests a new drug called PRO-203, given as a single shot under the skin. First, healthy volunteers will check safety; then, people with systemic sclerosis (a rare autoimmune disease that hardens skin and organs) will receive the drug. The main goal is to see…

This early-stage trial is testing a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how the drug moves through the body and whether it is safe when delivered directly to the lungs via an i…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects, see how long the drug stays in the body, and learn how it affects immune cells. About 96 participants will receive either a single…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This first-in-human trial tests an oral drug called SAR447971 (KT-485) in healthy volunteers and people with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The study has three parts: single and multiple doses in healthy people, and multiple doses i…

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests a new drug called JUV-161 to see if it can prevent muscle loss in healthy adults aged 40 to 65 who have one leg immobilized for about 6 weeks. Participants will receive weekly injections of either the drug or a placebo. The study will measure muscle changes using…

This early-stage study tests whether the experimental drug TAK-781 is safe and tolerable in healthy volunteers and in people with primary sclerosing cholangitis (PSC), a chronic liver disease. The study also looks at how the body processes the drug. About 134 participants will be…

This study tests an experimental drug called ALN-PNP for people with a type of fatty liver disease (MASLD) who have a specific gene variant. It is a first-in-human trial, meaning it is the first time this drug is given to people. The main goals are to check if the drug is safe, t…

This early-stage study tests an experimental drug, NNC4004-0002, in 60 adults with high uric acid levels but no symptoms. The main goal is to check safety and how the body handles a single injection. Participants receive either the drug or a placebo (saline) by chance. The study …

This early-stage study tests a new drug, CPTX2309, to see if it is safe and tolerable. It involves 64 healthy adults and people with moderate to severe rheumatoid arthritis or lupus. Researchers will monitor side effects, lab results, and immune responses to determine the drug's …

This study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…

This study tests whether artificial intelligence can plan cardiac MRI scans as accurately as expert radiographers. 150 adults will receive both an AI-planned and a standard scan, and doctors will compare the image quality and time taken. If successful, AI could help reduce long w…

This study tests a new, ultra-low dose PET scan that uses 10 to 100 times less radiation than standard scans to find neuroendocrine tumors. About 200 healthy volunteers and people with these tumors will get a radioactive tracer and be scanned for up to 3 hours. The goal is to see…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 2,200 healthy infants will receive four doses of either the new vaccine or an existing one starting at 2 mont…

This study tests the safety of a new drug called IGT-303 in healthy volunteers and people with chronic kidney disease (CKD). About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. Researchers will monitor for side effects t…

This study tests a new software called Motion Reset that may prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—when using virtual reality. Healthy adults aged 18 to 60 will try different VR experiences and then play a commercial VR game while reporting…

This study explores whether a 12-week program combining modern dance with mindfulness practices can improve psychological wellbeing, reduce stress, and enhance body awareness in healthy adults. About 160 recreational dancers will be randomly assigned to either the dance-mindfulne…

This early-stage study tests whether a device that sends mild electrical pulses to nerves and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions…

This study tests if mulberry leaf extract capsules are safe for healthy people with slightly high blood sugar. 48 volunteers will take either the extract or a placebo three times a day for 8 weeks. Researchers will check blood counts, liver and kidney function, and blood sugar le…

This early-stage study tests a new drug called ABCL635, given as a shot under the skin, to see if it can safely reduce hot flashes in postmenopausal women. The study includes healthy men and women without symptoms, as well as women with moderate-to-severe hot flashes. Researchers…

This study collects biological samples like blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. Researchers at the National Institutes of Health will use these samples to design and improve laboratory tests for other studies. Participants may be asked t…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will compare brain activity in 150 participants (fibromyalgia patients and healthy volunteers) using EEG and fMRI scans. In a later phase, some patient…

This study checks if a Turkish version of the Cybersickness in Virtual Reality Questionnaire (CSQ-VR) is valid and reliable. It involves 42 healthy volunteers who will answer questions about symptoms like nausea or eye strain after using VR. The goal is to ensure the tool works w…

This study is observing 2,000 adults across all weight categories to learn about the physical and behavioral traits linked to obesity. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and even genetics. The goal is to better understand why people b…

This early-stage study tests the safety of a new drug, CLYM116, in 48 healthy adults aged 18-60. Participants receive either the drug or a placebo by injection, and researchers monitor for side effects and how the drug moves through the body. The study is not designed to treat an…

This study looks at how the body's internal clock changes our perception of time when we stay awake for 36 hours. Thirty healthy adults will remain awake in a controlled lab, with constant light, posture, and food. Every two hours, they complete tests on time estimation, reaction…

This study tests a special camera that uses adaptive optics to take detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers hope this technology can detect eye diseases earlier than standard methods. The study will include up to 1,000 people…

This early-stage trial is testing a new drug called ME3241 in 104 healthy adults to see if it is safe and how the body handles it. Participants will receive either the drug or a placebo by infusion, and researchers will monitor for side effects and measure drug levels in the bloo…

This early-stage study is testing how different versions of a gene called CYP2D6 affect the way the drug KarXT is processed in the body. Researchers will give KarXT to 56 healthy adults and measure drug levels in their blood. The goal is to understand if people with certain gene …

This early-stage trial is testing a new drug called CHF6467, given as a nasal spray, in 68 healthy adults. The main goal is to see if it is safe and how the body processes it. The study will also check if the drug reaches the fluid around the brain and spinal cord, and whether it…

This study looks at whether taking cold showers regularly can improve how people cope with stress. About 120 healthy adults will either take warm showers with a cold burst at the end or just warm showers. Some will be told the showers are helpful, others won't get that informatio…

This early-stage study is testing a new drug called LAD106 in 93 healthy adults aged 18 to 45. The main goal is to see if it is safe and how the body processes it. Participants will receive either LAD106, a similar drug (lebrikizumab), or a placebo. This research is a first step …

This study tests whether a manual therapy technique called intercostal mobilization can improve breathing muscle strength and walking performance in healthy adults. Researchers will divide 90 sedentary volunteers aged 18-30 into three groups: one receiving the mobilization, one r…

This study is testing how much of the drug KarXT passes into breast milk and blood in healthy women who are breastfeeding. Eight participants will take KarXT and provide milk and blood samples over time. The goal is to estimate how much of the drug a nursing infant might be expos…

This study will use MRI and ultrasound to create detailed reference images of the heart, liver, and blood vessels in 2,400 healthy adults across France. By linking these images with health data, researchers hope to better understand normal aging versus disease, especially for con…

This early-stage trial is testing whether a new drug called B-3E07 works the same as the approved osteoporosis drug Forsteo. 48 healthy adult women will receive a single injection of each drug in random order. The main goal is to compare how the body absorbs and processes the dru…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study in 12 healthy volunteers tests whether biotin (vitamin B7) can be used to label platelets so they can be tracked after transfusion. Platelets are collected, labeled with biotin, stored for 3 days, then a small radioactive tag is added before returning them to the donor…

This study aims to establish normal scores for four paper-and-pencil tests that detect spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking adults aged 20 to 89, divided by age and sex. The results will help doctors know what…

This study looks at how taking a new drug (VV119) with or without a standard meal changes its levels in the blood. Sixteen healthy Chinese adults will receive a single dose of VV119 under both conditions. The goal is to understand food's effect on drug absorption and safety, not …

This early-stage study tests a single injection of GenSci161 in 44 healthy adults aged 18 to 45. The goal is to check safety, side effects, and how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo, and no one knows which …

This early-stage study tests the safety of a new drug called MT-251 in 70 healthy adults aged 19 to 55. Participants receive either the drug or a placebo to check for side effects and how the body processes the drug. The goal is to gather safety information, not to treat any dise…

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) can make high-intensity interval training (HIIT) more effective. Thirty healthy, trained adults will do an 8-week HIIT program on a stationary bike, with half also getting the tape bef…

This study follows 1,500 children ages 8-17 over several years to understand how genes, sleep, mood, and thinking skills affect eating behavior and health. Participants wear a wrist monitor, answer smartphone questions, and provide samples like saliva and blood. The goal is to id…

This study screens healthy adults aged 18 and older to see if they qualify for future infectious disease vaccine or treatment trials. It collects basic information like race, ethnicity, and gender to help researchers quickly find suitable volunteers. No treatment is given—this is…

This early-stage study tests an experimental drug called BMS-986521 in healthy adults to see if it is safe and how the body processes it. About 106 participants will receive either the drug or a placebo. The study does not aim to treat any disease; it is designed to gather import…

This study is creating a large database of healthy Caucasian knees using advanced CT scans, X-rays, and ultrasound. Researchers will analyze knee shape, ligament balance, and bone structure in 200 volunteers aged 20-35. The goal is to provide a reference for better understanding …

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tasks and brain imaging. The goal is to gather baseline data, not to treat any disease.

This early-stage study is testing a new drug called PBK_M2301 in 32 healthy adults aged 19 to 64. The goal is to see how the drug is absorbed and processed by the body, and to check for any safety concerns. Participants will receive the drug once and provide blood samples over ti…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes to learn a new physical skill, it might also boost nearby brain areas used for language. The study will …

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This study looks at whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how healthy people feel overall. About 120 healthy Chinese adults with low fruit and vegetable intake will take either the supplements or a placebo. Researchers will measur…

This study looks at whether longer or shorter training sessions help healthy adults maintain their endurance during a 4-hour cycling test. Researchers will measure changes in power output and heart rate. 40 volunteers who exercise up to 2 hours per week will participate.

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain networks be…

This study looks for better ways to measure what people eat, especially sugar, without relying on memory or food diaries. Researchers will give 60 healthy adults different amounts of sugar in their diets for 12 weeks and check for changes in blood, hair, and fat samples. The goal…

This early-stage study gives 10 healthy men a single dose of the experimental drug E2086 with a radioactive tracer. Researchers will measure how much of the drug appears in blood, urine, and stool over time. The goal is to understand how the body breaks down and eliminates E2086,…

This study looks at how sleep helps us learn visual tasks, like recognizing patterns. Ten healthy volunteers aged 18-30 will undergo brain scans (MRI) and sleep monitoring while doing visual exercises. The goal is to see which brain areas are active during sleep and how that rela…

This early-stage study is testing how the drug BMS-986435 behaves in the body and whether it is safe for people with mild to moderate liver problems compared to those with healthy livers. 24 adults will receive a single dose, and researchers will measure drug levels and monitor f…

This study tests whether a daily supplement called Cardiosyn can increase helpful gut bacteria in healthy adults who eat a typical Western diet. The supplement contains a natural sugar found in human milk along with probiotics. One hundred participants will take the powder for ab…

This study tests a new non-invasive brain stimulation technique called temporal interference (TI) that uses scalp electrodes to safely reach deep brain areas. Researchers will scan the brains of 30 healthy volunteers to see if TI can activate the nucleus accumbens without affecti…

This early-phase study is testing whether a new drug called ABBV-722 changes how the body processes several common medications. Twelve healthy adults will take ABBV-722 along with a 'cocktail' of drugs (midazolam, digoxin, pitavastatin, metformin, and sitagliptin) to see if their…

This early-stage study is testing LG-0317 tablets for the first time in people. About 100 healthy Chinese adults aged 18-45 will receive either the drug or a placebo to check for side effects and how the body processes it. The goal is to see if the drug is safe enough to move int…

This study aims to measure how quickly proteins are replaced in the body (protein turnover) in healthy adults aged 20 and older. Participants will drink heavy water for 21 days and undergo tests including muscle, skin, and fat biopsies, imaging scans, and strength tests. The goal…

This study collects blood, urine, saliva, and tissue samples from 500 adults with or at risk for urothelial cancer (bladder, ureter, urethra). Researchers will analyze DNA and other molecular changes to understand how the cancer forms and progresses. Participants provide samples …

This study tests whether adding a safe amount of nitrate—a natural compound found in leafy greens and beetroot—to common oat-based foods like biscuits, cereal bars, and porridge can improve nitric oxide levels and lower blood pressure. Thirty healthy adults will try each fortifie…

This study looks at whether sucralose, a common artificial sweetener, affects how the body absorbs and breaks down certain medications. Researchers will give healthy overweight volunteers either sucralose or a placebo for 28 days and measure changes in drug levels, hormones, gut …

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers to help researchers understand blood diseases like aplastic anemia. Participants must be 8 or older (18 for bone marrow). The samples are used for lab research only, not to treat any condition.…

This early-stage study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 40 healthy adults. Participants take a single dose on an empty stomach and are monitored closely. The goal is to gather basic safety and drug-le…

This study tests whether virtual reality or mental imagery can replace the standard prism adaptation therapy used for people with unilateral neglect after a brain injury. Researchers will compare these new methods to the traditional approach in 480 healthy volunteers. The goal is…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study looks at how thoughts and expectations change the way we feel pain. Healthy volunteers aged 18-50 will have brain scans and receive mild pain (heat or electric shocks) while researchers measure their heart rate, sweat, and brain activity. The goal is to understand pain…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography or CT scans in up to 4000 adults, including healthy volunteer…

This study collects blood and urine samples from healthy volunteers and patients to help researchers study genes, proteins, and other substances. The goal is to develop new lab tests and better understand diseases. Participants must be 18 or older and will have a short visit for …

This study screens up to 16,000 people aged 3 to 99 who have mood or anxiety disorders, or are healthy volunteers. The goal is to carefully evaluate participants for other research studies and collect natural history data. Participants undergo interviews, medical exams, brain sca…

This study tests how a new drug called repinatrabit interacts with other common medications like birth control pills, metformin, and methotrexate. It involves 48 healthy adults across four groups. The goal is to measure how these drugs affect each other in the body, which helps d…

This study is testing a new, more comfortable brain scanner that uses special sensors to measure brain activity. Researchers will compare this new device to a standard scanner in 80 healthy volunteers and athletes who have had a mild concussion. The goal is to see if the new scan…

This early-phase study tests the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, DWC202314) in 36 healthy adults after a meal. Participants receive single doses in random order and are monitored for side effects and drug levels. The goal is to gath…

This early-stage study is testing a new drug, Alpha-0261, for the first time in people. The goal is to see if it is safe and how the body processes it. About 60 healthy adults will receive a single dose of the drug or a placebo. No treatment benefit is expected; the study is pure…

This study aims to learn more about biomarkers—substances in blood and tissues—and how they relate to aging. Researchers will follow 900 healthy and frail adults over many years, collecting blood, urine, and tissue samples, along with memory tests and body scans. The goal is to f…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with cancer or blood disorders, as well as from healthy family members who are stem cell donors. The samples are used for research to better understand diseases, improve treatments, and find…

This early-stage study is testing the safety and tolerability of a drug called midomafetamine in 32 healthy adults aged 18 to 55. Participants receive either a standard or a higher dose and are closely monitored for side effects, heart changes, and how the drug moves through the …

This early-stage study tests a single dose of an experimental drug called KL0011034 in 76 healthy Chinese volunteers aged 18-45. The main goal is to check for side effects and how the drug moves through the body. Participants are randomly assigned to receive the drug, a placebo, …

This early-stage study is testing a new drug, SEP-479, in 150 healthy adults aged 21 to 60. The main goal is to check if the drug is safe and how the body processes it. Participants will take single or multiple doses of the drug or a placebo. This study does not aim to treat any …

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The goal is to see how safe it is and how radiation from it spreads through the body. Partici…

This early-stage study tests a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants will receive the drug and be monitored for side effects and drug levels in the blood. The study does not aim to treat any disease, bu…

This study tests a new device called pneuRIP that measures breathing without needles or tubes. It uses special bands placed around the chest and belly. Researchers will compare it to an existing monitor in 20 children—10 healthy and 10 with mild breathing problems from muscle or …

This early-stage study is testing a new drug called RO7806881 in healthy volunteers to see if it is safe and how the body processes it. About 128 healthy adults will receive either the drug or a placebo. The main goal is to check for side effects and measure drug levels in the bl…

This study looks at how taking itraconazole (a common antifungal) changes the way the body processes an experimental drug called ABBV-722. It involves 12 healthy adults and focuses on safety and drug levels in the blood. The goal is to gather information, not to treat any disease…

This study looks at how the body absorbs different versions of the drug emraclidine in 12 healthy adults. Participants take a single dose of each version and have their blood tested. The goal is to compare the drug levels and check for side effects, not to treat any disease.

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Fifteen volunteers will walk with different levels of assistance from the exoskeleton. Researchers will measure step length, speed, muscle activity, and foot pressure to understand the devi…

This early-stage study tests a new drug called YN001 in 24 healthy adults aged 18 to 65. The goal is to see how the drug moves through the body and check for side effects. Participants receive a single dose and are monitored closely. This study does not treat any disease.

This early-stage study tests a new drug called KLA578-1 in 48 healthy volunteers aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either a single dose or multiple doses, and researchers will monitor for side eff…

This study collects blood samples from 1000 healthy adults aged 18 and older. The blood is used to improve tests and understand blood vessel and immune diseases. Participants get $50 per visit and can donate up to 10 years. No treatment or cure is involved.

This study tests a single dose of ITI-1284 in 42 healthy adults aged 18-55. Researchers will use brain scans to see how much of the drug attaches to certain brain receptors. The goal is to gather safety and drug-level information, not to treat any disease.

This study looks at how social and cultural factors affect the way people express pain and how others assess it. Researchers will measure pain responses in healthy volunteers and test whether training can improve accuracy in judging others' pain. The goal is to understand and red…

This early-stage study tests whether ARGX-124 is safe in healthy adults aged 18 to 65. Researchers will also measure how the drug moves through the body and how the immune system reacts. About 104 participants will receive either the drug or a placebo, and the study lasts up to 2…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This early-stage study is testing new forms of two drugs, KarX and KarT, in 72 healthy adults. Researchers want to see how the body absorbs and processes these new versions compared to the original drugs, and whether food changes their effects. The goal is to gather safety and do…

This study checks if the experimental drug BMS-986278 affects the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive multiple doses of the drug, a placebo, and a positive control in a crossover design. The main goal is to measure changes in heart…

This study looks at whether emergency room doctors can use ultrasound to clearly see the muscle layers in the belly wall, which is needed for a type of pain block called a TAP block. About 118 healthy adults will get an ultrasound scan of their abdomen. The goal is to see if body…

This study looks at how the body absorbs a drug called empasiprubart when given as a shot under the skin using an autoinjector compared to through an IV. It involves 130 healthy adults aged 18 to 65. The goal is to understand the drug's behavior and safety, not to treat any disea…

This study looks at how healthy brains process social information, like understanding others' feelings. Researchers will use brain scans (fMRI) and brain wave recordings (EEG) to see which brain areas are active during social thinking tasks. The goal is to create a baseline of no…

This early-stage study tests whether LIFE-001 is safe and tolerable in 150 healthy adults aged 18 to 65. Participants receive single or multiple doses, and researchers monitor side effects and how the drug moves through the body. There is no expected treatment benefit for volunte…

This study collects skin, blood, and other samples from people with skin diseases, their family members, and healthy volunteers. The goal is to understand what causes different skin conditions and find better ways to treat them. Participants provide samples like blood, skin biops…

This study looks at how laser light bounces off different parts of the eye, like the cornea and retina. Researchers will measure the reflected light at various angles and colors in 20 healthy volunteers aged 18-40. The goal is to make laser-based eye exams and surgeries safer and…

This study aims to make MRI scans better by testing new imaging techniques. Researchers will scan healthy adults and current NIH participants to find the best settings for different body parts. Participants may have multiple scans over several years, with blood draws and possibly…

This study is testing a new device that uses light to measure pulse waves and estimate blood pressure. Researchers want to see if it works as well as current standard methods. The study involves 27 healthy adults aged 18 and older.

This study looks at how a drug called atumelnant affects and is affected by other medicines in healthy adults aged 19-55. It involves two groups of participants to measure drug levels and safety. The goal is to understand how the body processes these drugs together, which helps g…

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. 42 participants will take AR-LDD alone and then with each of the other drugs to see the difference. This is a phase 1 trial with no direct treatment …

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS uses magnetic pulses to stimulate the brain and is already approved for depression. Researchers want to understand these brain changes to help design better treatments fo…

This study looks at whether a common grip strength device can reliably measure how well healthy people sense the force they apply with their hand. Researchers will ask 55 volunteers aged 18-24 to grip at a target force and then repeat it, measuring accuracy and consistency. The g…

This early-stage study tests whether a single dose of KLA478 is safe and how the body processes it. About 40 healthy adults aged 18-45 will receive the drug and be monitored for side effects and drug levels in the blood. No treatment benefit is expected; the goal is to gather saf…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This early-stage study is testing whether adding D-serine to psilocybin (the active ingredient in magic mushrooms) can reduce its psychedelic effects while keeping it safe. Ten healthy adults aged 25-60 will receive one of two dose combinations and be closely monitored for side e…

This study collects blood plasma and white blood cells from healthy volunteers, HIV patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH s…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, given as an injection or IV. The study does not aim to treat any disease, but to gat…

This study looks at how a new drug called KarXT changes the way the body processes three other drugs: midazolam, fexofenadine, and digoxin. It involves 60 healthy adults and aims to measure drug levels in the blood. The results will help doctors understand if KarXT can be safely …

This study looks at how a part of the brain called the posterior parietal cortex (PPC) helps us combine vision and body awareness to guide hand movements. Researchers will compare people with optic ataxia (a condition caused by PPC damage that affects reaching and grasping) with …

This early-stage study tests whether ALN-4915 is safe and how it behaves in the body. About 44 healthy adults will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels, not to treat any disease.

This early-stage study tests a new drug called ZE74-0282 in 40 healthy adults aged 18-55. The main goal is to check its safety and how the body handles it, not to treat any disease. Participants receive either the drug or a placebo, and researchers monitor side effects and drug l…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Thirty healthy adults aged 18-50 will receive TI stimulation while their brain activity is measured with fMRI. The goal is to understand ho…

This study aims to understand what happens in the brain when someone has thought about or attempted suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people who recently had suicidal thoughts or attempts, those with p…

This study looks at how well different tablet versions of the drug BMS-986435 are absorbed by the body in 140 healthy adults. It also checks if eating food changes absorption. The goal is to find the best tablet form for future use, not to treat any disease.

This early-stage study is testing a new drug, AKB-9090, in about 70 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, given through a vein, in either a single dose or multiple doses over time. The main goal …

This study is testing how well certain brain and heart monitoring tools work in healthy people, Parkinson's patients, and those with paralysis. The goal is to prepare for future clinical trials by figuring out the best ways to collect data. No treatment is being tested—just the m…

This early-stage study is testing a single dose of an experimental drug called VV913 in 56 healthy Chinese men aged 18 to 45. The goal is to see if the drug is safe and how the body processes it. Participants are randomly assigned to receive either VV913 or a placebo, and no dire…

This early-stage study is testing a single dose of an experimental drug called VV261 in 58 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants will be randomly assigned to receive either VV261 or a placebo, and no …

This study looks at how hidden factors, like how we see things or our age, affect the choices we make. Researchers will test 200 healthy adults to see if decision-making stays stable or changes with different tasks. The goal is to create a baseline to better understand decision-m…

This study collects white blood cells from healthy volunteers using a procedure called cytapheresis. The cells are used for lab research, not to treat any disease. Participants must be 18 or older and can donate every 56 days.

This early-stage study is testing a new drug called ALN-4285 in healthy adults to see if it is safe and how the body processes it. Participants receive a single injection of the drug or a placebo. The study is currently recruiting 76 volunteers.

This study looks at how changing what you eat changes the energy your body uses to digest and process food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals. Researchers will measure their energy use in a special room to understand …

This study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18 to 40. Only 3 people will take part, and each will try 8 different drink combinations. The goal is to see if these drinks cause any heart rhythm changes, not to treat or cure any…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Researchers will measure brain activity in 30 healthy adults using MRI scans. The goal is to understand how deep brain regions work and lay…

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…

This study looks at how healthy adults use timing patterns in sounds and speech to predict what comes next. Researchers will use brain scans (EEG and MEG) and behavioral tests to understand these processes. The goal is to improve language learning, not to treat any disease. About…

This study is an early safety check for a new drug called HW241045, which may one day help treat a lung disease called IPF. Researchers are giving a single dose to 56 healthy adults to see if it is safe and how the body processes it. No treatment benefit is expected for participa…

This early-stage study tests whether a new drug, ZP9830, is safe and how it behaves in the body. About 124 healthy adults aged 18-45 will receive either the drug or a placebo. The goal is to check for side effects and learn how the drug is processed, not to treat any disease.

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples over a short period. The goal is to understand how the body handles this compound,…