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Hidden heart helper: Nitrate-Fortified biscuits could lower blood pressure

NCT ID NCT07172425

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a safe amount of nitrate—a natural compound found in leafy greens and beetroot—to common oat-based foods like biscuits, cereal bars, and porridge can improve nitric oxide levels and lower blood pressure. Thirty healthy adults will try each fortified food in a random order, and researchers will measure nitrate levels in their blood, saliva, and urine over 24 hours. The goal is to find an affordable, tasty way to support heart health for everyone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inorganic potassium nitrate added to oat-based foods (biscuits, cereal bars, porridge)
What this could lead to
If successful, this could point toward a simple, low-cost way to add heart-healthy nitrate to common foods, potentially helping manage blood pressure in populations that cannot afford expensive supplements.
What could go wrong
This is a very early, small study in only 30 healthy volunteers. It tests short-term effects, not long-term benefits or real-world use. The results may not apply to people with high blood pressure or other health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy volunteer. 2. Aged ≥18 years and ≤ 60 years. 3. Willing to provide informed consent. 4. Able to understand and comply with protocol requirements, instructions, and stated restrictions. Exclusion Criteria: A volunteer will not be eligible for inclusion in this study if any of the following criteria are met: 1. Unwilling to provide consent. 2. People with chronic health conditions requiring medication. 3. Pregnant females, or those with a possibility of being pregnant. 4. History of hypertension and /or diabetes. 5. History of any serious illnesses, including recent infections or trauma. 6. History of symptomatic coronary artery disease, stroke, or other known atherosclerotic diseases. 7. People who will commence or who are likely to commence treatment with non-steroidal anti-inflammatory drugs (NSAIDs) other than aspirin, from screening until study completion. 8. Self-declared alcohol or drug abuse within the past 6 months. 9. Three-month prior history of regular alcohol consumption exceeding an average weekly intake of \> 28 units (or an average daily intake of greater than 3 units) for males, or an average weekly intake of \> 21 units (or an average daily intake of greater than 2 units) for females. One unit is equivalent to a half pint (284mL) of beer/lager; 25mL of spirits, or 125mL of wine. 10. Taking systemic medication (other than the oral contraceptive pill). 11. Recent (within 2 weeks) self-reported use of mouthwash or tongue scrapers. 12. Recent (within 2 weeks) or current antibiotic use. 13. Recent (within 1 week) use of NO3- or NO2- supplements. 14. History, or recent treatment of (within the last 3 months) for any oral condition (excluding caries), including gingivitis, periodontitis and halitosis. 15. History of, or recent treatment for, any blood-borne infectious disease such Hepatitis B or C virus, or HIV. 16. Current smokers (including vaping) or have smoked within the last 6 months. 17. Diagnosis of rheumatoid arthritis, connective tissue disorders, and other conditions known to be associated with chronic inflammation (e.g., Inflammatory Bowel Disease). 18. People who have donated more than 500mL of blood within 56 days prior to the study commencement. 19. Known allergy to celery, gluten, crustaceans, eggs, lupin, milk, mustard, peanuts, sesame, soybeans, tree nuts, oats, palm oil, sugar, cranberries, sunflower oil, invert syrup, sodium bicarbonate.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The William Harvey Research Institute, Centre for Cardiovascular Medicines and Devices, Queen Mary University of London

    RECRUITING

    London, EC1M 6BQ, United Kingdom

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