Queen Mary University Of London

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a specific type of high blood pressure called primary aldosteronism. About 122 adults with this condition will be randomly assigned to one of the two treatments. The goa…

This study tests whether adding durvalumab to datopotamab deruxtecan works better than datopotamab deruxtecan alone for people with PDL1-negative metastatic triple-negative breast cancer, a type that doesn't respond to standard immunotherapy. About 140 women will be randomly assi…

This study tests whether giving the drug natalizumab (Tyruko®) within 14 days of first MS symptoms can help repair nerve damage better than a placebo. It involves 40 adults aged 18-55 who have had a first episode of demyelination (suggestive of MS) and show at least two brain les…

This study is testing whether a drug called ixazomib, which is already used for a type of cancer, is safe for people with multiple sclerosis (MS). The drug targets certain immune cells that may drive MS. About 72 adults with relapsing-remitting or progressive MS will take either …

This study tests whether the drug atezolizumab can shrink tumors in people with certain types of urothelial cancer before they have surgery. About 58 adults will receive two doses of the drug, which helps the immune system attack cancer cells. After treatment, they will have stan…

This study aims to detect heart valve disease and heart failure in people aged 65 and older from diverse communities. Researchers will train non-expert staff in GP offices to perform quick cardiac ultrasound scans. The goal is to find hidden heart problems early, reduce emergency…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs to find inherited gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smartphone app to decide if they want testing…

This study looks at how to best prevent dangerous blood clots in people who have a leg cast or splint after an injury. Over 10,000 participants will be split into high- and low-risk groups. High-risk patients will get either tablets or injections, while low-risk patients may get …

This study tests whether a special gel, made with hyaluronic acid and octenidine, can improve early healing after standard deep cleaning for gum disease. About 26 adults with advanced periodontitis will receive either standard care or standard care plus the gel. Researchers will …

This study compares 3 versus 6 cycles of platinum-based chemotherapy before maintenance avelumab in 320 people with advanced bladder cancer. The main goal is to see which approach leads to better quality of life. Participants receive either 3 or 6 cycles of chemo, then avelumab e…

This study tests whether a doctor's recommendation to join an online asthma support group helps adults with troublesome asthma control their symptoms and feel better. 600 participants will be followed for 12 months to see if the digital community improves asthma control, anxiety,…

This study looks at whether giving extra support and advice helps people with obstructive sleep apnea use their mouthpiece more regularly. About 56 adults aged 40 and older will be split into two groups: one gets routine care, the other gets additional support. Researchers will t…

This study looks at whether a new community-based program can help reduce loneliness in young adults aged 20 to 40 living in London. The program offers social activities, online spaces, and low-cost events to encourage connections. Researchers will measure how well the program wo…

This study looks at whether getting a dental implant right after a tooth is pulled (immediate placement) or waiting a while (delayed placement) changes how the mouth heals. Researchers will measure healing markers in saliva and gum fluid from 24 adults over 30 days. The goal is t…

This study looks at how blood flows through stented arteries to understand why some stents develop dangerous clots. Researchers will compare blood flow patterns in 120 people who have had a stent placed, including some who later had a clot. The goal is to find markers that could …

This study aims to collect tumor and blood samples from 3000 adults with solid tumors to learn why cancers become resistant to treatments and spread. Researchers will use advanced lab tests to find molecular clues. The goal is to develop better treatments and tests for individual…

This study looks at whether two safe, non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support like CPAP or high-flow oxygen. Up to 10…

This study will follow 20,000 people who had a heart attack and were discharged early from the hospital. Researchers want to see how well their medications are adjusted, how many have another heart event, and how their quality of life changes over a year. The goal is to learn wha…

This study is creating a registry of 3000 people who had a heart attack but no blocked arteries (called MINOCA). The goal is to learn more about this condition, improve diagnosis, and understand long-term outcomes. Participants will be followed over time to track symptoms and hea…

This study looks at whether adding natural nitrate (found in leafy greens and beetroot) to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified foods in a …

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to understand what factors lead to worse outcomes and to improve how doctors predict and manage these conditions. No new treatments or proc…

This study aims to understand how air pollution impacts pregnancy and the risk of preterm birth. Researchers will use artificial intelligence to analyze health records from 18,000 pregnant women in London, along with pollution data from their neighborhoods. The goal is to create …

This study looks at whether using a balloon to block the aorta (a major blood vessel) during a heart attack outside the hospital can help blood flow to the heart and brain. It involves 40 adults who are in cardiac arrest and receiving standard emergency care. The goal is to see i…

This study looks at whether being active in high air pollution is worse for children's lungs than just resting in the same polluted air. Researchers will measure lung function and immune responses in 330 schoolchildren in London. The goal is to understand how short-term air pollu…

This study is testing whether men with stage II seminoma testicular cancer can receive less intensive treatment without harming their health. Researchers will track 30 patients in two UK hospitals to see if they are willing to join the study, how their cancer responds, and how th…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Inflammation is a normal response to injury or illness, but when it goes unchecked, it can lead to diseases like rheumatoid arthritis and heart problems. Researche…

This study tests a small, wearable sensor that measures lactate levels through the skin in people recovering from heart surgery. Researchers want to see if the sensor is as accurate as standard blood tests. If it works, it could mean fewer needle sticks and faster monitoring for …

This study looks at why healthy women might be better at calming inflammation than men, which could help explain differences in heart disease risk. Researchers will create small blisters on the skin of 34 volunteers and measure how their bodies respond over 72 hours. The goal is …

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study looks at 1,500 people with a common skin cancer called cutaneous squamous cell carcinoma. Researchers want to see how well current staging systems predict if the cancer will come back or spread. The goal is to improve how doctors assess risk and manage this cancer.

This study follows 60 adults undergoing thoracoabdominal aorta repair to understand why about half develop persistent pain around the incision. Researchers will use sensory tests, pain scores, and blood/spinal fluid analysis to identify risk factors. The goal is to find ways to p…

This study is collecting information from 1500 people who either have a blood clot in the main heart chamber (left ventricular thrombus) or are at high risk for developing one. The goal is to learn what factors lead to clot formation and how to better manage the condition, which …