HEALTHY VOLUNTEERS

This study tested a new vaccine to protect against four types of meningococcal bacteria, which can cause serious infections like meningitis. Over 1,500 healthy infants and toddlers in India and South Africa received the vaccine alongside their regular childhood shots. The goal wa…

This study tested a new flu vaccine that includes an extra H3 strain, aiming to improve protection. Around 400 healthy adults aged 18-49 and 60+ received either the new vaccine or a standard one. Researchers monitored safety and immune responses over about 3 weeks.

This early-stage study tested an experimental mRNA vaccine designed to prevent lower respiratory tract disease caused by RSV and hMPV viruses. About 558 healthy adults aged 18-49 and 60+ received a single injection at different doses. Researchers monitored safety and immune respo…

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the body's immune response against all four typ…

This study tested whether a new vaccine called HSV529 is safe for people. It included 69 healthy adults aged 18 to 40, some with and some without herpes infection. Participants received three shots of the vaccine or a placebo and were monitored for side effects over a year. The g…

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. Participants received two doses at 6 and 12 months old. The goal was to see if the new vaccine works as well as an existing vaccine (Nimenrix) and is safe. The study is complete and aims to …

This early-stage study tested the safety and immune response of new vaccines that combine protection against influenza, RSV, hMPV, and parainfluenza virus type 3. A total of 270 healthy adults aged 18 to 49 received a single shot of one of the vaccine formulations. Researchers mo…

This early-stage study tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The goal was to check if the vaccine is safe and triggers an immune response. Participants received one shot and were monitored for side effects like reactions at the injection sit…

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to check the vaccine's safety and how well it boosts the immune system, i…

This study tested a new meningitis vaccine (MenACYW) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix®) and also checked safety when given alongside HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine provides simila…

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood does not clot properly. Mim8 is injected under the skin to replace the missing clotting factor and prevent bleeding episodes. The trial included 275 healthy volunteers and people wi…

This early-phase trial tested an experimental imaging agent called 18F-LNC1007 in 8 people—healthy volunteers and cancer patients with a small number of tumors. The goal was to see how the agent spreads through the body, how much radiation it gives off, and whether it is safe. Pa…

This study tested whether replacing certain ingredients in cookies with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially preventing obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-based cooki…

This study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults aged 60 and older. About 2,100 healthy older adults in Japan took part. Researchers measured immune responses 28 days after vaccination to see if the high-dose version triggered s…

This study looked at whether taking Rhodiola rosea (golden root) for one week can improve exercise performance and thinking skills in healthy adults who already lift weights regularly. Twenty-seven men and women tried a low dose, a high dose, a placebo, and a no-capsule control i…

This study looked at whether three different food supplements can improve skin firmness, elasticity, and radiance in healthy women aged 40 to 60. Over 130 women took the supplements or a placebo daily for three months. Researchers measured skin properties like firmness, density, …

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after meals with different amounts of fat and vitamin E. The goal was to understand how much vit…

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body processes each version and to check for any safety issues. Participants received a single injection and were monitored for about …

This early-stage study tested the safety of a new drug called SIM0278 in 60 healthy Chinese adults. Participants received either the drug or a placebo as a single or multiple injections. The goal was to check for side effects and measure how the drug moves through the body, not t…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part. The goal was to understand how liver function affects drug levels, not to treat a disease.

This study looked at how a tablet form of the drug ABBV-722 is absorbed and processed by the body in 11 healthy adults. Researchers also checked whether eating food changes how the drug works. The goal was to gather basic safety and body-processing information, not to treat any d…

This early-stage study tested a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. The main goal was to check if the drug is safe and how the body processes it. No treatment or weight-loss benefit was measured; this is purely a safety and dosing s…

This study looked at how overeating at different times of day affects inflammation and metabolism. Researchers measured blood markers in 16 healthy adults after they ate extra calories. The goal was to see if eating late in the evening is worse for the body than eating earlier.

This study looked at how alcohol changes the way the brain processes social cues and alcohol-related images. Researchers tested a technique called neurofeedback, where people see their own brain activity in real time and try to control it. 101 adults (some with alcohol use disord…

This study looked at whether a specific mRNA COVID-19 vaccine (mRNA-1273.712) causes a rise in a heart enzyme called troponin, which can signal heart stress. About 1000 healthy volunteers aged 12 to 30 received either the vaccine or a placebo. Researchers measured troponin levels…

This study looked at how the brain controls and adjusts quick eye movements called saccades, which help us see and interact with the world. Thirty-six healthy adults aged 18 to 40 had their brains scanned with MRI while performing eye-tracking tasks. The goal was to identify whic…

This early-stage study tested the safety and tolerability of a new drug called SAR441344 in 56 healthy adults. Participants received either the drug or a placebo through an IV or injection. The goal was to see how the body handles the drug and if it causes any side effects.

This study looked at how healthy people remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI and tracked eye movements to understand how attention during learning affects later recall. The goal was to learn more about memory…

This early-stage study tested the safety and tolerability of a new drug called BMS-986278 in 42 healthy adults. Researchers also checked whether the drug affects the heart's electrical activity. The goal was to gather safety data, not to treat any disease.

This study tested two different tablet forms of the experimental drug rilzabrutinib in 28 healthy adults aged 18 to 55. The goal was to see how well each form is absorbed by the body, both with and without food. Participants took a single dose of each tablet in a random order, wi…

This study looked at how well two new dissolvable forms of the drug vonoprazan are absorbed by the body compared to the standard tablet. Twenty-five healthy adults took single doses of each version, including one mixed with water and given via syringe. The goal was to see if thes…

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers m…

This study looked at the long-term safety of the malaria drug tafenoquine in 600 healthy volunteers. Participants took either tafenoquine or a placebo daily for three days, then weekly for 51 weeks. The main focus was on eye health, checking for any serious changes in the retina.…

This study tested a non-invasive device that gently stimulates a nerve in the ear (vagus nerve) in 44 healthy adults. Researchers measured brain activity and pain response to see how the stimulation affects the nervous system. It was a mechanistic trial, meaning it aimed to under…

This study looked at how different versions of an experimental drug, BMS-986460, are absorbed by the body. It involved 85 healthy adult men and focused on safety and drug levels in the blood. No treatment or disease was studied, so the goal was simply to gather information for fu…

This study looked at whether being in labour slows how fast the stomach empties a light meal. Researchers used ultrasound to measure stomach size in 43 women: those in labour with or without epidural, pregnant women not in labour, and non-pregnant women. The goal is to help guide…

This study looked at how nicotine from different oral nicotine pouches gets into the blood of 27 healthy adults who already use snus or nicotine pouches. Participants tried four different products over a short stay in the clinic, and researchers measured nicotine levels in their …

This early-stage study tested a new drug called AJ302-IM in 57 healthy adults to see if it is safe and how the body processes it. Participants received a single injection of either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood,…

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects and measured drug levels in the blood. The goal …

This early-stage study looked at how taking the drug rilzabrutinib with or without food, and in different pill forms, changes the way the body absorbs it. Twenty-four healthy adults each took a single dose under different conditions. The goal was to gather information for future …

This early-stage study tested the safety and tolerability of a new drug, LAD191, in 69 adults—some healthy and some with an autoimmune disease. The main goal was to see if the drug causes side effects and how the body processes it. No treatment benefits were expected; this was pu…

This study looked at how healthy adults' immune systems respond to the seasonal flu vaccine and the H1N1 (swine flu) vaccine. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to better understand the body's defense me…

This study looked at whether a new drug called EB-1020 could be abused like other stimulants. 80 healthy adults who use stimulants recreationally took single doses of EB-1020, a placebo (fake drug), or d-amphetamine (a known stimulant) and rated how much they liked the effects. T…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. Healthy women aged 18 to 35 did jump tests while wearing the sensor and using a smartphone app that is already proven to work. The goal was to see if the sensor gives simila…

This study tested a single 16 mg dose of selatogrel in 32 healthy adults (16 Japanese, 16 Caucasian) to see how the drug moves through the body and how well it is tolerated. It was not meant to treat any disease. Participants stayed in a clinic for a few days and had follow-up ch…

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis before symptoms ap…

This early-stage study tested the safety and tolerability of a new drug called AG-181 in 88 healthy adults. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moves through the body. The goal was not to treat any diseas…

This study looked at how L-lysine, a common amino acid, affects two important hormones: aldosterone and cortisol. Twenty healthy men took L-lysine or a placebo for 13 days, then switched. The goal was to learn how the body controls these hormones, not to treat any disease. No dir…

This study tested a single dose of the drug BMS-986278 in 27 people: some with healthy kidneys, some with severe kidney disease, and some on dialysis. The goal was to see how kidney problems affect drug levels and safety. Results will help doctors decide the right dose for future…

This study looked at how brain activity recorded from inside the skull (intracranial EEG) relates to signals from non-invasive scans like fMRI and MEG. Researchers studied 47 people with drug-resistant epilepsy and healthy volunteers. The goal was to better identify the brain are…

This study used a special 3D camera system (stereophotogrammetry) to take pictures of the torso in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. The goal was to improve the imaging technique and learn more about how body shape differs across thes…

This study looked at whether a 30-minute walk outdoors in a green space helps people recover from mental tiredness and stress better than a 30-minute walk on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outside in nature, the other walked on…

This early-stage study tested a new drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers to see if it is safe and how the body processes it. Participants took the drug as capsules, either once or daily for a week, and were closely monitored in the clinic. The result…

This study tested a new fixed-dose combination tablet containing two drugs, zanubrutinib and sonrotoclax, in 24 healthy adults. The goal was to see how well the body absorbs the combo pill compared to taking the drugs separately, and whether food changes absorption. Participants …

This study looked at how a medication called deucravacitinib enters breast milk and blood in healthy women who are breastfeeding. Eight participants took a single dose, and researchers measured drug levels over time. The goal was to understand how much of the drug a nursing infan…

This study tested a new drug, TAK-004, in 121 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo as an injection under the skin. The goal was to check for side effects, effects on heart rate and blood pressure, and …

This early-stage study tested the safety and how the body handles a new drug called atumelnant. It involved 21 healthy Japanese and Caucasian adults who took either the drug or a placebo. The goal was to measure drug levels in the blood and check for side effects, not to treat an…

This study tested a new biosimilar drug called MB04 against two versions of Enbrel (EU and US) in 141 healthy men. Researchers measured how much drug stayed in the blood and checked for side effects and immune reactions. The goal was to see if MB04 works similarly to Enbrel, not …

This study looked at how two common drugs (phenytoin and itraconazole) change the amount of BGB-16673 in the blood of 37 healthy adults. The goal was to understand if these drugs affect how BGB-16673 is processed by the body. Results will help doctors decide the right dose when B…

This study looked at how two different versions of the drug centanafadine are absorbed by the body. 62 healthy adults took either a sustained-release tablet or an extended-release capsule. The goal was to compare the amount of drug reaching the bloodstream, not to treat any disea…

This study looked at how collagen from drinks gets into the bloodstream. Twenty-five healthy men drank different collagen products, and their blood was tested over four hours. The goal was to see which amino acids and small protein pieces appear after drinking collagen, not to tr…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older after they received the 2020-2021 flu vaccine. The samples were sent to health experts to analyze immune responses and help choose the right flu strains for future vacc…

This early-stage study tested the safety of a new drug, KINE-101, in 40 healthy volunteers. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The goal was to gather safety information, not to tr…

This study looked at how a small genetic difference (called TaqIB) affects the way HDL, or 'good' cholesterol, works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL helped remove cholesterol f…

This study looked at how aging skin cells (senescent cells) appear around small wounds in healthy adults. Researchers compared younger (20-39) and older (70+) volunteers to see if age affects wound healing. The goal is to better understand aging and age-related diseases, not to t…

This early-stage study tested a single dose of the experimental drug ENX-104 in 12 healthy adults. Researchers compared how the drug is absorbed when given as a liquid or a tablet, and whether a high-fat meal changes absorption. The goal was to gather safety and drug-level data, …

This study looked at 12 people with chronic balance problems (bilateral vestibular hypofunction) and 12 healthy volunteers to understand how rapid eye movements called covert saccades help stabilize vision during head motion. Researchers tested different visual conditions to see …

This early-stage study tested a new antibody called AK1967 (Procizumab) in 24 healthy men to see if it is safe and how the body processes it. The antibody blocks a protein that may worsen shock by breaking down a key blood-pressure-raising molecule. This research is a first step …

This study tested a new device called E-celsius, which is a pill you swallow that measures your body temperature as it travels through your digestive tract. Researchers compared its readings to standard temperature probes in 22 healthy adults. The goal was to see if the pill is a…

This study looked at whether a dietary supplement made from silver fir branches, called Belinal®, is safe for the liver and kidneys. Fifteen healthy adults took the supplement daily for 14 days, and researchers measured their blood for signs of liver or kidney stress. The goal wa…

This early-stage study tested a drug called TAK-123 in 10 healthy Japanese men to see how the body processes it and if it causes side effects. The goal was to gather safety and drug-level information, not to treat any disease. Participants received a single intravenous dose and w…

This study measured how quickly nicotine enters the bloodstream from three different products: an electronic vapor product (e-cigarette), a nicotine inhaler, and a regular cigarette. Twelve healthy smokers took part. The goal was to understand the nicotine levels each product del…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET brain scans to see how much of the drug attached to a specific brain receptor (5-HT2A) and checked safety and drug levels in the blood. The goal was …

This study looked at how complex our natural movements are by having 60 healthy volunteers perform a tapping test. Researchers measured patterns in their performance to understand sensorimotor behavior better. The goal was to explore whether these measurements could one day help …

This early-stage study tested a new drug called HD-P023 in 40 healthy adults to see how it compares to taking two diabetes medications (teneligliptin and empagliflozin) separately. Researchers measured how the drugs move through the body and checked for safety. The study is compl…

This study looked at how arm position affects the size of veins seen on ultrasound in 50 healthy adults. The goal was to find the best arm position for placing catheters. Researchers measured the surface area of the subclavian and axillary veins with the arm down and with the arm…

This study tested a single dose of teprotumumab in 20 healthy Chinese adults to see how the drug moves through the body and if it is safe. Participants were randomly assigned to receive the drug or a placebo. The study is complete and provides early safety and drug-level data, bu…

This study tested whether a special camera can see tiny blood vessels (microcirculation) in healthy volunteers during brief periods of weightlessness on a parabolic flight. The goal is to better understand how the heart and blood vessels adapt to space, which could help prevent f…

This study tested how well healthy adults tolerate a new immune globulin injection called TAK-881. Sixty-four participants received one or more doses under the skin, with some getting a gradual ramp-up and others not. The goal was to see if the infusion could be completed without…

This study looked at how two different versions of an inhaled drug (TPIP) are absorbed by the body. It involved 42 healthy adults who received single doses of each version. The goal was to see which formulation delivers the drug more consistently, helping guide future treatment d…

This study looks at how brief periods of weightlessness during parabolic flights change the brain's memory center (hippocampus) and spatial thinking. Twenty-four healthy adults will take memory tests and have brain scans before and after flying. The goal is to understand how spac…

This study looked at how oxycodone, a painkiller, is absorbed and processed by the body when given as a nasal spray or an oral solution. Eight healthy adults took a single dose of each form on separate days. The goal was to gather data to improve computer models that predict how …

This study tested whether a gentle electrical current applied to the brain during a nap can increase specific sleep brainwaves and improve emotional well-being. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the s…

This study looked at how many people are needed to find most of the mistakes people make when using a medical device called Zeneo®. Researchers tested 60 healthy volunteers, some who knew about auto-injector pens and some who didn't. The goal was to improve future device testing,…

This study tested a single 4 mg dose of cenerimod in 20 healthy volunteers (10 Japanese, 10 Caucasian) to see how safe it is and how the body handles it. It was not meant to treat any disease. Participants stayed in the clinic for 4 days and had follow-up visits over about 75 day…

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18 to 55. The goal was to check safety and how the drug behaves, not to treat any disease.

This study looked at whether giving growth hormone can improve how the immune system works in healthy men. The researchers wanted to see if the hormone, which naturally drops with age, could help the body fight infections better. Sixty-six men between 25 and 50 took part, receivi…

This study looked at how a new medicine called etavopivat affects the heart's electrical activity. It involved 33 healthy adults aged 18 to 55. Participants received different doses of the medicine, a placebo, or an approved heart drug to compare effects. The goal was to ensure t…

This study looked at how the drug maribavir is absorbed and processed in healthy Japanese and Caucasian adults. 24 participants took a single oral dose to compare safety and drug levels in the blood. The goal was to see if the drug behaves differently between the two groups and a…

This early-stage study tested the safety of a new drug called NRS 033 in 24 healthy adults aged 18 to 55. Participants received either a single dose of the drug or a placebo, and researchers monitored side effects and how the drug moved through the body. The goal was to gather sa…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults (65 and older) after they received their seasonal flu vaccine. The samples were sent to health agencies to help decide which flu strains to include in future vaccines. No new treatm…

This study looked at how pleasant five different flavors of benzydamine HCl lozenges taste. 60 healthy adults and 60 healthy children each held a lozenge in their mouth for 10 seconds without swallowing, then rated its taste, aftertaste, and texture using a questionnaire with a 7…

This study gave 8 healthy men a single dose of OPC-167832 containing a tiny radioactive marker. Researchers measured how much of the drug came out in urine and stool over time. The goal was simply to understand how the body processes and eliminates the drug, not to treat any dise…

This early-stage study tested the safety and tolerability of a new drug called LAD603 in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and whether it causes side effects. The study is complete and provides fou…

This early-stage study tested the safety and how the body handles a single dose of ALN-AGT01 RVR in 42 healthy adults. Participants were randomly assigned to receive either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood and urin…