HEALTHY VOLUNTEERS

This early-stage trial tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. About 558 healthy adults aged 18 to 49 and 60 years or older received one injection of the vaccine at different doses. The main goals were to check safety…

This early-stage trial tested whether a new vaccine called HSV529 is safe for people. The vaccine aims to prevent genital herpes caused by the herpes simplex virus type 2. A total of 69 healthy adults aged 18 to 40 received either the vaccine or a placebo shot. Researchers monito…

This study tested a new meningitis vaccine (MenACYW conjugate vaccine, also called MenQuadfi) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix) and also looked at giving it together with HPV and Tdap-IPV vaccines. The goal was to …

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets two parts of the flu virus (hemagglutinin and neuraminidase) to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety a…

This study tested a new investigational vaccine that aims to protect against five types of meningococcal bacteria (A, B, C, W, Y) in one shot. It involved 1,215 healthy participants aged 10 to 25. The main goals were to check the vaccine's safety and how well it triggers an immun…

This early-stage trial tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The goal was to check safety and how well the vaccine triggers an immune response. Participants received either the experimental mRNA vaccine or a standard high-dose flu shot. Resu…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3 in healthy adults aged 18 to 49. Participants received a single shot of one of several vaccine formulas. The goal was to see if these combination …

This study tested a new vaccine to protect infants and toddlers against four types of meningococcal bacteria, which can cause serious infections like meningitis. Over 1,500 healthy children in India and South Africa received the vaccine along with their regular shots. The goal wa…

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo shot. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in …

This study tested a single dose of an experimental meningitis vaccine (MenACYW) in 447 healthy people aged 12 months and older in Vietnam. The vaccine aims to protect against four types of meningococcal bacteria that cause serious infections like meningitis. Researchers measured …

This study tested a new dengue vaccine in over 20,000 healthy children aged 4 to 16 years. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. The vaccine was given as a shot under the skin and compared to a placebo. Results s…

This study looked at whether a booster dose of the MenQuadfi vaccine is safe and effective in healthy toddlers aged 12 to 23 months who had already received a different meningitis vaccine as babies. The goal was to see if the booster could strengthen their protection against meni…

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the immune response against all four types of d…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults (65 and older) after they received their seasonal flu vaccine. The samples were sent to health agencies to help choose which flu strains to include in future vaccines. Participants …

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to see if the vaccine is safe and triggers a strong immune response, with…

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. The goal was to see if it works as well as an existing vaccine (Nimenrix) when given as two shots at 6 and 12 months of age. The trial measured immune response and monitored safety to suppor…

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This study tested a new flu vaccine that includes an extra H3 virus strain, aiming to improve protection. About 400 healthy adults aged 18-49 and 60+ received either the new vaccine or a standard one. Researchers checked for side effects and measured immune responses over 3 weeks…

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This study tested whether a daily supplement called Immulina, made from Spirulina, can help healthy people fight off upper respiratory viruses like the flu. Researchers measured natural killer cell activity and other immune markers in 492 healthy adults aged 18-59 and 65+. Partic…

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood doesn't clot properly. Mim8 is given as a shot under the skin to help prevent bleeding episodes. The trial included 275 healthy volunteers and people with hemophilia A, with or with…

This early-stage trial tested a new radioactive imaging agent called 68Ga-LNC1007 in 8 healthy volunteers and solid tumor patients. The goal was to check its safety, how it moves through the body, and how well it shows up on scans. Participants received a single injection and wer…

This early-phase trial tested a new radioactive imaging agent called 18F-LNC1007 in 8 people—some healthy and some with a few small tumors. The goal was to see how the agent moves through the body, how much radiation it gives off, and if it is safe. Participants had PET/CT scans …

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease. Researchers compared brain scans from 230 people, including those with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to see if the tracer …

This Phase 3 trial tested a new rabies vaccine (VRVg-2) in 1708 healthy children and adults in Thailand. The goal was to see if it works as well as two existing rabies vaccines when given before exposure to the virus. Participants received a series of shots, and some got a booste…

This study tested a high-dose flu vaccine (QIV-HD) against the standard dose in over 1,500 adults aged 60 and older. The goal was to see if the high-dose version triggers a stronger immune response against four flu strains. Researchers measured antibody levels 28 days after vacci…

This study looked at whether it is safe and effective to give a high-dose flu vaccine and a Moderna COVID-19 booster at the same time to adults aged 65 and older. 306 participants who had already received two doses of the Moderna vaccine were enrolled. Researchers measured side e…

This study tested a new drug called MAM01 to see if it can safely prevent malaria for at least 4 months. It involved 125 healthy adults and children living in parts of Africa where malaria is common. Researchers checked for side effects and measured how the drug moves through the…

This study tested different versions of a quadrivalent (four-strain) flu vaccine in 210 healthy adults aged 18–30 and 50+. The goal was to see how safe they were and how well they triggered the immune system to fight flu viruses. Participants received one shot and were monitored …

This early-phase study tested whether black raspberry confections could help prevent oral cancer in 67 healthy volunteers. Researchers measured how the body absorbed berry compounds and how they affected genes linked to cancer and inflammation. The goal was to find the best dose …

This study tested whether a high-dose flu vaccine could create a stronger immune response than the standard dose in adults aged 60 and older. Over 2,100 healthy seniors in Japan received either the high-dose or standard-dose vaccine. Results showed that the high-dose shot trigger…

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). 33 healthy adults with fair to medium skin had creams applied to their back before being exposed to a specific blue-vi…

This study tested whether replacing some ingredients in cookies with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially lowering the risk of obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-base…

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This pilot study tested whether eight sessions of the Feldenkrais Method—a gentle, mindful movement practice—could lower stress and improve body fluid balance in 24 healthy but sedentary women aged 26–59. Participants were split into a Feldenkrais group and a control group. Resea…

This completed study tested three different food supplements against a placebo in 132 healthy women aged 40-60. Over three months, researchers measured skin firmness, elasticity, density, cellulite visibility, and radiance. The goal was to see if these botanical extracts could im…

This study looked at the best time to give a combination of two sedatives (remimazolam and remifentanil) during a painless stomach scope exam. 342 healthy adults took part to see if changing when the drugs are given reduces side effects like coughing, body movement, and drops in …

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to se…

This study looked at whether taking Rhodiola rosea (golden root) for 7 days can improve strength, endurance, and mental focus in healthy adults who already do resistance training. Twenty-seven men and women each tried a low dose, a high dose, a placebo, and a no-capsule control p…

This study tested whether TRPTI (oleoylethanolamide) can improve how healthy adults handle sugar. Nineteen participants took either 150 mg, 300 mg, or a placebo in random order, then had their blood sugar and insulin levels measured after a sugary drink. The goal was to see if TR…

This completed Phase 1 trial enrolled 30 healthy adults aged 18-50 to compare how the body absorbs and clears two antibody treatments given as a single injection under the skin: TAK-881 and HyQvia. Participants stayed at the clinic for 8 days and had follow-up visits up to Day 85…

This completed early-phase study gave a single oral dose of ENX-104 to 10 healthy volunteers to check its safety, how the body processes it, and how well it binds to D2/D3 receptors in the brain. The main goal was to track any side effects. Since this was a small, first-in-human …

This completed study measured oxygen and carbon dioxide levels in the throat of 14 healthy volunteers while they received oxygen through a nasal cannula, face mask, or standard non-rebreather mask. The goal was to understand how different delivery methods affect gas composition i…

This study used brain scans (fMRI) to see what happens in the brain when healthy people meditate or are hypnotized. 100 volunteers completed tasks and reported their experiences. The goal is to understand how these practices change self-awareness, which could help explain their h…

This study tested a new version of the allergy drug fexofenadine (Allegra) to see if it works when taken without water. 25 healthy adults received both the new and standard tablets under fasting conditions. The goal was to compare how much drug gets into the blood and how fast. T…

This study in 200 healthy Pakistani adults looked at whether a common gene variation (CYP2C9*3) changes how well ibuprofen works for pain after a molar tooth extraction. Participants took ibuprofen or a placebo, and researchers measured pain levels and side effects. The goal was …

This completed Phase 1 study tested two drugs that act on the body's endocannabinoid system—nabilone (a cannabinoid receptor agonist) and CP-945,598 (a cannabinoid receptor antagonist)—in 45 healthy men aged 21 to 55. The goal was to understand how these drugs influence insulin p…

This study tested a new ultrasound technique to measure blood flow inside the shin bone of 30 healthy men. Researchers used simple exercises and pressure cuffs to see how bone blood vessels react. The goal is to develop a tool that could one day help monitor bone health in astron…

This completed Phase 1 trial tested whether the experimental drug ziresovir affects the heart's electrical activity in 34 healthy adults. Participants received different doses of ziresovir, a placebo, and an active control (moxifloxacin) to compare effects. The main goal was to m…

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This early-phase study tested a single injection of ORKA-001 in 24 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The main goal was to check for side effects and changes in vital sign…

This completed Phase 1 study looked at how the drug golcadomide is processed in the body of people with moderate or severe liver impairment compared to healthy volunteers. 29 adults received a single dose, and researchers measured drug levels and safety. The goal is to understand…

This study looked at how healthy men process and eliminate a single dose of venglustat, a drug being developed for certain rare metabolic diseases. Six healthy male volunteers took a radioactive form of the drug so researchers could track it in urine, feces, and blood. The goal w…

This study tested a single injection of a new drug, NNC0194-0499, in 33 adults with either normal liver function or mild to severe liver impairment. The drug is being developed for non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH. The main goal was to see…

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis, a common and pain…

This study tested how much nicotine gets into the blood from four different oral nicotine pouches. Twenty-seven healthy adults who already use snus or nicotine pouches took part. Each person tried all four products in a random order, and researchers measured nicotine levels in th…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This completed Phase 1 trial tested a single 16 mg dose of selatogrel, an injectable drug that affects blood clotting, in 32 healthy adults (16 Japanese and 16 Caucasian). The goal was to see how the body absorbs and processes the drug and how well it is tolerated. This study was…

This completed Phase 1 trial tested how oxycodone moves through the body when given as a nose spray or an oral liquid. Eight healthy volunteers received a single dose of each form on separate days. The goal was to gather data to improve computer models that predict how drugs beha…

This completed study looked at how different types of meat (minimally processed vs. further processed) combined with two diet patterns (high or typical Healthy Eating Index) affect markers of heart disease risk. 60 healthy adults participated. Researchers measured blood levels of…

This study looked at how brief periods of weightlessness during parabolic flights (like a roller-coaster in the sky) affect spatial memory and brain structure. Twenty-four healthy volunteers took part, undergoing brain scans and cognitive tests before and after flying. The goal w…

This early-stage trial tested a single injection of the experimental drug NNC0582-0001 in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo and were followed for a year. The study is complete, but it was not d…

This Phase 1 trial enrolled 28 healthy adults to compare how two different tablet forms of rilzabrutinib (a drug for autoimmune disorders) are absorbed by the body, both with and without food. Participants received single doses of each form in a random order, with a day between d…

This early-phase trial tested the safety and tolerability of a new drug called MT-501 in 72 healthy adults aged 19 to 55. Participants received either single or multiple oral doses of MT-501 or a placebo. The main goal was to monitor for side effects and how the drug moves throug…

This study used functional MRI to see which parts of the brain are active when people adjust their eye movements (saccades) to keep vision accurate. Thirty-six healthy adults performed eye-tracking tasks while in the scanner. The goal was to map the brain networks behind this aut…

This study tested a new method to measure how hard a person is breathing while using a non-invasive ventilator (a mask that helps with breathing). Researchers used a brief airway occlusion (a short pause in airflow) to estimate breathing effort in 12 healthy volunteers. If proven…

This completed Phase 4 study looked at how much deucravacitinib (SOTYKTU®), a drug for plaque psoriasis, passes into breast milk. Eight healthy lactating women took a single dose, and researchers measured drug levels in their milk and blood. The goal was to estimate how much of t…

This completed Phase 1 trial studied how a single dose of the experimental drug OPC-167832 is eliminated from the body. Eight healthy men took the drug, which was tagged with a tiny amount of radioactivity, and researchers measured how much came out in urine and stool. The goal w…

This study looked at how much nicotine people get from blu disposable e-cigarettes compared to their usual brand of regular cigarettes. Twenty adult smokers used both products in controlled sessions, and researchers measured nicotine levels in their blood and their urge to smoke.…

This early-stage study gave a single dose of a radioactive-labeled version of the experimental breast cancer drug amcenestrant to 6 healthy postmenopausal women. The goal was to track how the drug is absorbed, broken down, and eliminated from the body. The results will help guide…

This study looked at how two different versions of the drug centanafadine are absorbed by the body. 62 healthy adults took either a sustained-release tablet or an extended-release capsule. The goal was to compare the amount of drug that reaches the bloodstream, not to treat any d…

This early-stage study tested a new tablet (HD-P023) against taking two diabetes drugs separately in 40 healthy adults. Researchers measured how the drugs move through the body and checked for safety. The goal was to see if the combination pill works similarly to the separate med…

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after meals with different amounts of fat and vitamin E. The goal was to learn more about vitami…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This early-stage study tested a new drug, AJ302-IM, in 57 healthy adults to see if it is safe and how the body processes it. Participants received a single injection of either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not …

This study tested whether healthy adults can safely digest protein from purple bacteria. Twelve participants ate a dairy product with or without added purple bacteria on two separate days. Researchers measured amino acid levels in their blood over four hours to see how well the b…

This study looked at how different types of feedback (like social or monetary) affect decision-making in 76 healthy adults. Researchers used brain scans and a mild stimulation technique to understand which brain areas are involved. The goal is to apply this knowledge to help peop…

This study tested a 3D camera system called stereophotogrammetry to measure body shape without radiation. About 200 people took part, including those with scoliosis, chest wall deformities, obesity, and healthy volunteers. The goal was to improve the imaging method, not to treat …

This study involved 8 healthy men to understand how the drug JNT-517 is absorbed, broken down, and removed from the body. Participants took a single dose containing a radioactive tracer so scientists could measure the drug in blood, urine, and stool. The goal was purely to gather…

This study looked at the long-term safety of tafenoquine, a drug used to prevent malaria, in 600 healthy adults. Participants took either tafenoquine or a placebo daily for three days, then weekly for 51 weeks. The main goal was to check for any serious eye problems, with follow-…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This early-stage study tested a single dose of the experimental drug ALN-AGT01 RVR in 42 healthy adults to check its safety and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The study is now complete, and results will help…

This study looked at how a small genetic difference (called TaqIB) affects the way 'good' HDL cholesterol works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL helped remove cholesterol after …

This study looked at whether L-lysine, a common amino acid, changes levels of aldosterone and cortisol—hormones that control salt balance and stress. Twenty healthy men took L-lysine or a placebo for 13 days, then switched. Researchers measured hormone responses to standing, a dr…

This early-stage study tested the safety and tolerability of a new drug called ITI-333 in 32 healthy adults aged 18 to 45. Participants received either the drug or a placebo once daily for 14 days. The goal was to measure how the drug moves through the body and check for any side…

This early-stage study tested the safety of a new drug called KINE-101 in 24 healthy adults. Participants received daily intravenous doses for a week at different strength levels. The goal was to check for side effects and how the drug moves through the body, not to treat any dis…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. Researchers gave 66 healthy adults and people with depression either the steroid or a placebo for three days, then used memory tests and advanced MRI s…

This study tested 40 healthy adults to see how napping in different environments—including a special SOMBOX module—affects driving ability and alertness compared to resting without a nap. Participants completed simulated driving tests and vigilance tasks. The goal is to find the …

This study looked at whether adding motivation to mental imagery or watching actions could improve lower back strength in healthy adults. Forty people were split into four groups: some did mental imagery, some watched actions, and some did these with added motivation. Strength wa…

This study looked at brain activity in 47 people with drug-resistant epilepsy and healthy volunteers. Researchers used two noninvasive brain scans (MEG and fMRI) at the same time as electrodes placed inside the brain (intracranial EEG). The goal was to better locate the source of…

This study looked at how a tablet form of the drug ABBV-722 is absorbed and processed in 11 healthy adults. Researchers measured drug levels in the blood and checked if taking it with food changes absorption. The goal was to gather basic safety and body-processing information, no…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults, including healthy volunteers and people with fatty liver (hepatic steatosis). The main goal was to check safety and how the drug moves through the body after a single injection under the skin. Particip…

This study looked at why some people with chronic balance problems make very fast eye movements (covert saccades) during head turns, which may help reduce blurry vision. Researchers tested 12 patients and 12 healthy volunteers under different visual conditions to see what trigger…

This study tested a single dose of the experimental drug etavopivat in 24 healthy Chinese adults. Researchers measured how the drug moves through the body and checked for side effects over about a week. The goal was to gather safety and dosing information for future studies in pe…

This study looked at how giving a single shot of the experimental drug KAI-9531 in different places (upper arm, thigh, or belly) changes the amount of drug that gets into the blood. It involved 51 healthy volunteers with a range of body sizes. The goal was to find the best inject…

This early-stage study tested a new drug, EI1071, in 58 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. The goal was to gather initial safety data, not to treat any …

This early-stage study tested the safety and how the body handles two experimental drugs (GEH200521 and GEH200520) given together to 22 healthy adults. The goal was to see if the drugs are safe and how they spread through the body using PET scans. This study does not aim to treat…

This early-stage trial tested the safety of a new drug, VNRX-7145, in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the body handles the drug and if any side effects occur. The study is complete and focused o…

This study tested a new device called E-Celsius, which is a pill you swallow that measures your body temperature as it travels through your digestive tract. Twenty-two healthy volunteers took the pill, and researchers compared its readings to standard thermometers placed in the r…

This early-stage trial tested the safety and tolerability of a new drug called AG-181 in 88 healthy volunteers. Researchers gave single or multiple doses to see how the body processes the drug and whether it causes any side effects. The study also looked at how food affects drug …

This early-phase trial tested how well healthy adults tolerate TAK-881, a combination of immune globulin and hyaluronidase given as an injection under the skin. Sixty-four participants received different dosing schedules to see if the infusion could be completed without interrupt…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This early-stage trial tested the safety of a new drug called KINE-101 in 40 healthy volunteers. Participants received a single dose either through a vein or under the skin. The main goal was to check for side effects and how the drug moves through the body. No treatment benefit …

This study tested whether a non-invasive imaging technique can measure tiny blood vessels (microcirculation) during brief weightlessness on parabolic flights. Sixteen healthy volunteers were observed during 21-second periods of zero gravity. The goal was to understand how the car…

This study looked at how many people are needed to find usability errors in the Zeneo® auto-injector pen, a device used for severe allergic reactions. 60 healthy volunteers used a demo version during a simulated anaphylactic shock. The goal was to improve device design by catchin…

This early-stage study looked at how taking rilzabrutinib with or without food, and in different pill forms, changes the amount of drug in the blood. Twenty-four healthy adults each received a single dose under various conditions. The goal was to find the best way to take the med…

This Phase 1 study tested the safety and tolerability of a single intravenous dose of AK1967 (Procizumab) in 24 healthy male volunteers. AK1967 is an antibody that blocks a protein called DPP3, which may worsen blood pressure drops during cardiogenic shock. The study only looked …

This study looked at how genetic differences in an enzyme called CES1 affect the activation of enalapril, a common blood pressure drug. Twenty-one healthy volunteers took enalapril for a week, and researchers measured drug levels and activity. The goal is to understand why some p…

This early-stage trial tested the safety and tolerability of an experimental drug called AZD1163 in 108 healthy volunteers. Participants received either the drug or a placebo by IV or injection, and researchers monitored side effects and how the drug moved through the body. Since…

This early-phase trial tested the safety of a new drug called BB-025, designed to reverse the effects of another experimental drug, BB-031. 72 healthy volunteers received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The main goal was to check…

This completed Phase 4 study tested whether an updated COVID-19 vaccine (mRNA-1273.712) affects heart muscle in healthy people aged 12 to 30. Researchers measured a heart enzyme called troponin in 1,000 participants who received either the vaccine or a placebo. The goal was to se…

This early-stage study tested the safety and how the body processes a new drug called nacresertib in 93 healthy adults. Participants received either single or multiple doses of the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not…

This study looked at how aging cells appear around small skin wounds in healthy people. Researchers compared younger adults (20-39) with older adults (70+) to see if there are differences. The goal was to better understand aging and age-related diseases, not to test a treatment.

This early-stage trial tested the safety and tolerability of an experimental drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers. Researchers gave the drug as single or multiple daily doses and monitored participants closely for side effects, blood levels, and lab …

This study looked at how different light conditions affect tiredness and mental performance in healthy adults after staying awake all night. 18 volunteers aged 18-40 were monitored for fatigue, hormone levels, and cognitive test results. The goal was to better understand sleep lo…

This study looked at how the drug belumosudil affects certain proteins in the body that process other medications. Fifty-two healthy men took belumosudil along with other drugs to see how their bodies handled them. The goal was to gather safety and interaction information, not to…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This early-stage study tested the safety and tolerability of a new drug called BMS-986278 in 42 healthy adults. Researchers also checked whether the drug affects the heart's electrical activity. The goal was to gather important safety information before testing the drug in patien…

This early-stage study tested a single dose of the experimental drug selonabant in 40 healthy adults aged 18 to 30. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side…

This early-stage study tested a single dose of the experimental drug NRS 033 in 24 healthy adults aged 18 to 55. The main goal was to check safety and how the drug moves through the body. No treatment was given for any disease, so this study does not offer any direct health benef…

This study looked at whether being in labour slows how fast a light meal leaves the stomach. Researchers used ultrasound to measure stomach emptying in 43 women: those in labour with or without an epidural, pregnant women not in labour, and non-pregnant women. The goal is to help…

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers a…

This study looked at how a single dose of ENX-104 is processed by the body when given as a liquid or a tablet, and whether a high-fat meal changes that. Twelve healthy adults took part. The goal was to gather safety and drug-level information, not to treat any disease.

This study tested several new versions of insulin lispro in 54 healthy adults to see how quickly the body absorbs and removes them, and whether they cause any side effects. The goal was to gather safety and drug-level information, not to treat a disease. The study lasted up to 10…

This study involved 120 healthy volunteers (60 adults and 60 children) who tasted five different flavored lozenges for 10 seconds each. They then answered a questionnaire about taste, aftertaste, and texture using a simple smiley-face scale. The goal was to see which flavor peopl…

This study looked at how eating too much at different times of day affects inflammation and metabolism in healthy adults. Researchers measured over 50 inflammatory markers and 500 metabolites in blood samples. The goal was to understand if eating late in the evening is worse for …

This study tested a new way to give TB skin tests using a special microneedle instead of the standard method. The goal was to see if the new method is easier to use and gives more consistent results. 59 healthy volunteers with positive or negative TB skin tests took part. The stu…

This study looked at how doing isometric exercises (holding a muscle still) at different knee angles affects balance, body awareness, and daily movements in healthy adults. Thirty people aged 18-26 did an 8-week training program. The goal was to find which knee angles work best f…

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database of normal gait patterns. Researchers measured muscle activity in the legs using sticky electrodes while children walked back and forth. The goal is to help doctors better ident…

This study looked at whether giving the drug zilucoplan through a prefilled syringe or an auto-injector works the same in the body. It involved 14 healthy adults aged 18 to 55. The goal was to compare how the drug is absorbed and to check safety, not to treat any disease.

This study looked at whether giving growth hormone can improve how the immune system works in healthy men aged 25 to 50. Participants received either growth hormone or a placebo through a small pump under the skin. The goal was to see if the hormone could reverse age-related immu…

This study looked at how cooling the brain changes its activity in healthy adults. Participants wore a cooling cap while researchers measured brain responses using transcranial magnetic stimulation (TMS). The goal was to better understand brain plasticity, not to treat any diseas…

This early-stage study tested the safety of a new drug called ARGX-213 in 88 healthy adults aged 18 to 65. Researchers measured how the drug moves through the body and checked for side effects over about 21 weeks. Since it involved healthy volunteers, the goal was to gather safet…

This study measured how much of a brain protein called PDE10A is occupied by a single dose of TAK-063 in 13 healthy adult volunteers. Researchers used special brain scans (PET scans) to see the drug's effect at 3 and 23 hours after taking it. The goal was to understand how the dr…

This study is for research only and does not treat any disease. It tests how safe a single dose of cenerimod is and how the body absorbs and breaks it down. The study includes 20 healthy adults—10 Japanese and 10 Caucasian—who stay in the clinic for 4 days and have follow-up visi…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used safe brain scans, EEG, and eye-tracking tests at three ages. The goal was to understand normal development and how early experiences shape the brain. This…

This early-stage study tested the safety of a new drug called MT-701 in 46 healthy adults aged 19 to 55. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, …

This study tested whether gentle electrical stimulation during naps can increase certain brain waves linked to emotional health. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the stimulation helped. The goal was …

This study tested a new drug called atumelnant in 21 healthy adults from Japanese and Caucasian backgrounds. The goal was to see how the drug moves through the body and if it is safe. Participants took the drug or a placebo by mouth once daily. This early-stage study does not aim…

This study looked at how two common drugs (phenytoin and itraconazole) change the way the body handles BGB-16673. It involved 37 healthy adults aged 18-65. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at whether a 12-week strength and power training program could improve movement patterns, physical fitness, and leg strength in Chinese college sports dancers. Thirty healthy female dancers with at least one year of experience took part. They were split into two…

This early-stage study tested a new drug called BMS-986419 in 74 healthy volunteers to see if it is safe and how the body processes it. The study also checked if the drug affects the heart's electrical activity. Since participants were healthy, the goal was only to gather safety …

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study tested how well risankizumab enters the body when given through an on-body injector compared to a standard prefilled syringe. It involved 260 healthy adults and measured drug levels and side effects. The goal was to see if the new injector works as well as the syringe,…

This study tested how food and a common stomach-acid drug (rabeprazole) affect the amount of an experimental medicine called ZN-A-1041 in the blood. Twenty-four healthy adults took the drug under different conditions to measure absorption. The goal was to learn how to best take t…

This study looked at how the body absorbs different versions of the drug povetacicept in 136 healthy volunteers. The goal was to compare the drug's formulations and check for safety. No treatment was given—just observation of how the drug moves through the body.

This study looked at whether taking the acid-reducing medicine famotidine changes how the body processes a new drug called afimetoran. It involved 32 healthy adults and used a crossover design to compare drug levels with and without famotidine. The goal was to gather safety and d…

This study looked at how 10 different drugs are broken down in the body. Ten healthy volunteers took the drugs, and researchers measured levels in the blood to create a personal metabolic profile. The goal was to learn more about drug processing, not to treat any disease.

This early-stage study tested the safety of a new drug, SIM0278, in 60 healthy Chinese adults. Participants received either the drug or a placebo as a single or multiple injections. The goal was to check for side effects and measure how the drug moves through the body, not to tre…

This early-phase study tested the safety of a new drug called VRG50635 in 22 healthy adults aged 19 to 55. Researchers measured side effects and how the drug moves through the body. The goal was not to treat any disease but to gather essential safety data before future studies.

This early-stage study tested the safety and how the body handles two experimental antibodies (AZD5396 and AZD8076) in 61 healthy adults. Participants received the antibodies through injections followed by a mild electrical pulse to help the body produce them. The goal was to che…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study looked at how complex our movements are by measuring finger-tapping patterns in 60 healthy volunteers. The goal was to understand normal sensorimotor behavior and see if these measurements could be useful in future clinical settings. No treatment was given; it was pure…

This study looked at how healthy adults remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain help us recall details. The goal was to learn more about memory and attention, not to treat …

This study measured how much nicotine gets into the blood from an e-cigarette, a nicotine inhaler, and a regular cigarette. Twelve adult smokers each tried all three products in a random order. The goal was to understand the nicotine levels each product delivers, not to treat any…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. Twenty-nine healthy women aged 18-35 did countermovement jumps while wearing the sensor and using a smartphone app. The goal was to see if the sensor gives results similar t…

This early-stage study tested the safety of a new drug called MF-300 in 100 healthy adults. Participants received either a single dose or multiple doses to see how the drug moves through the body and what side effects occur. The goal was to gather safety information, not to treat…

This study tested a new pill that combines two drugs (zanubrutinib and sonrotoclax) used to treat blood cancers. 24 healthy adults took the pill to see how well it is absorbed by the body, both with and without food. The goal was to compare the combination pill to taking the two …

This study looked at how repotrectinib, a cancer drug, changes the way the body processes other medications. Thirty healthy adults took repotrectinib along with a mix of common drugs like metformin and omeprazole. The goal was to measure drug levels in the blood to understand pot…

This study tested a non-invasive technique called transauricular vagus nerve stimulation (taVNS) in 44 healthy adults. Participants received a gentle electrical pulse to the ear for 60 minutes to see how it changes brain activity and the body's ability to handle pain. The goal wa…

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults aged 18 to 55. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug le…

This study looked at whether taking creatine and L-arginine together, just once, can improve short bursts of exercise and mental reaction time in healthy, active men. Eighteen men tried each supplement alone, together, or a placebo in random order. They did sprint tests, jump tes…

This study tested a new biosimilar drug (MB04) against two versions of Enbrel in 141 healthy men. The goal was to see how the drugs move through the body and if they cause side effects or immune reactions. Participants received a single dose and had blood samples taken over sever…

This study tested whether a new medicine called etavopivat, being developed for sickle cell disease, affects the heart's electrical activity. Thirty-three healthy adults received different doses of the drug, a placebo, or an approved heart medication. The goal was to check for an…

This study tested whether a new version of the drug dupilumab works the same as the current version in the body. It involved 182 healthy adults aged 18 to 65. Participants received a single injection of either the new or current drug, and researchers measured drug levels and side…

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body processes each version and check for side effects. Participants received a single injection and were monitored for about 17 weeks…

This study looked at 50 healthy adults to see if changing arm position makes veins in the armpit and collarbone area show up bigger on ultrasound. The goal was to find the best arm position for easier and safer vein access. Results help guide doctors when placing central lines.

This study looked at how a new drug called KarXT interacts with three common mood stabilizers (lithium, valproic acid, and lamotrigine) in 133 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to understand if these drugs aff…

This early-stage study tested the safety and tolerability of Ginkgolide B injection in 36 healthy adults aged 18 to 45. Participants received single or multiple doses to see how the drug behaves in the body and what side effects occur. The goal was to gather safety data, not to t…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18 to 55. The main goal was to compare the drug levels in the blood and check for any safety issues after a single dose.

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outdoors in nature, the other walked indoors in a…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This early-stage study tested the safety and how the body handles a new drug called SEP-631 in 120 healthy adults aged 18 to 60. Participants received either the drug or a placebo to check for side effects and measure drug levels in the blood. Since this is a Phase 1 trial in hea…

This study tested how a new drug called CS0159 interacts with other common drugs (rifampicin and itraconazole) and a high-fat meal in 32 healthy adults. The goal was to measure drug levels in the blood and check for side effects. This helps researchers understand how to use CS015…

This study tested two new dissolvable forms of vonoprazan (a stomach acid reducer) to see how well they work compared to the standard tablet. Twenty-five healthy adults took single doses of each form, either without water or mixed with water and given via syringe. The goal was to…

This study looked at how collagen from drinks gets into the blood. Twenty-five healthy men drank different collagen products or a placebo. Blood samples were taken before and up to 4 hours after drinking to measure collagen building blocks. The goal was to see which products are …

This study tested two different tablet forms of an experimental drug called UCB0022 in 14 healthy adults. The goal was to see how well each form is absorbed into the body and to check for any safety issues. Participants took a single dose of each tablet on separate occasions, and…

This study looked at whether online nutrition workshops can help hospital employees switch to a more plant-based diet that is also better for the planet. 64 healthy adults working at a hospital took part. They were split into two groups: one got a 2-hour weekly digital program, t…

This study collected blood samples from 90 healthy volunteers—children aged 6 months to under 9 years and adults 65 and older—after they received the 2020-2021 flu vaccine. The samples were sent to experts at the WHO, CDC, and FDA to help decide which flu strains to include in fu…

This study looked at how the body processes vitamin C, especially how water intake changes vitamin C levels in the blood. 23 healthy adults followed a low-vitamin C diet and then took vitamin C pills and injections. Researchers measured vitamin C in blood and urine to understand …

This early-stage study tested a new drug called SAR441344 in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or infusion. The main goal was to monitor any side effects over several months.

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study looks at why certain drugs, like the antifungal voriconazole and the antibiotic doxycycline, can cause an exaggerated sunburn reaction called phototoxicity. Researchers will measure gene activity in skin samples from 62 participants (ages 8 and up) to better understand…

This study looked at how healthy adults' brains handle the decision to double-check their work. Using brain scans (fMRI and EEG), researchers aimed to pinpoint which brain areas are active during checking tasks. The goal is to better understand compulsive checking in conditions l…

This early-stage study tested a single dose of the experimental drug EA5 in 28 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either EA5 or a placebo, and neither they nor the doctors knew who got which. The goal …

This study tested a new tablet form of Magne-B6 (magnesium and vitamin B6) against the current liquid version in 24 healthy adults. Participants took both forms on separate days, and researchers measured how much magnesium and vitamin B6 got into their blood and urine. The goal w…

This study looked at how two different tablet versions of the drug BGB-43395 are absorbed by the body in healthy adults aged 18 to 65. It also checked if eating food changes how the drug works. The goal was to find the best tablet form and understand food effects, not to treat an…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The drug is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the dru…

This study tested two different pill forms of an experimental drug called PF-07976016 in 12 healthy adults. The goal was to measure how much of the drug gets into the blood after a single dose. No treatment was given — the study was only to help Pfizer decide which pill form to u…

This early-stage study tested a new oral drug called IPG1094 in 76 healthy adults aged 18 to 50. The main goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. This trial …

This study looked at how the liver affects the body's processing of cagrilintide, a drug being developed for weight management. It involved 32 participants with different levels of liver function and healthy volunteers. The goal was to measure drug levels in the blood, not to tre…

This study tested a new way to collect fluid from the skin using a tiny microneedle patch. Researchers compared samples from 20 healthy volunteers and people with eczema (atopic dermatitis) to see how much fluid could be collected and how well it was tolerated. The goal was to le…

This early-stage study tested the safety and tolerability of a single dose of TRL345 in 16 healthy adults aged 18 to 65. The goal was to gather important safety data and understand how the drug moves through the body. Results will help design future studies in transplant patients…

This study tested a single dose of the drug teprotumumab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and to check for any side effects. Participants were randomly assigned to receive either the drug or a placebo, and no one knew whic…

This study aimed to collect detailed measurements of the spine and pelvis in 161 healthy adults using a special low-dose X-ray technology called EOS. By understanding what a normal, pain-free spine looks like, doctors hope to better diagnose and treat people with lower back pain.…

This study tested two different versions (a tablet and a capsule) of an experimental medicine called NDec, which is being developed for sickle cell disease. 44 healthy adults each took a single dose of both forms to see how the body absorbs them. The goal was to compare the two f…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET scans to see how much of the drug reached and attached to a specific brain receptor (5-HT2A). The main goals were to measure receptor binding, drug l…

This early-stage study looked at how different versions of an experimental drug, BMS-986460, are processed by the body. Eighty-five healthy adult men took part to check safety and drug levels. The goal was to gather information, not to treat any disease.

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver problems change drug levels. The results will guide dosing for pa…

This study looked at how the body processes a single dose of maribavir in healthy Japanese and Caucasian adults. Researchers wanted to see if there are differences in drug levels and safety between the two groups. The goal is to help determine the right dose for Japanese patients…

This early-stage study tested a new experimental drug, NNC0113-6856, in 70 healthy men to see if it is safe and how the body processes it. Participants received either a single oral dose or an injection into the vein. The goal was to gather initial safety data and measure drug le…

This early-stage study tested the safety and tolerability of a new drug, LAD603, in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and if it causes side effects. The goal was to gather initial safety data, not …

This early-phase study tested the safety and how the body processes TAK-123 in 10 healthy Japanese men aged 20-45. Participants received a single intravenous infusion, and researchers measured drug levels in the blood and monitored for side effects. The study was completed and pr…

This study looked at how taking a new drug called vamifeport with or without food changes the amount that gets into the blood. 28 healthy adults took the drug twice, once with food and once without, to compare. The results will help doctors decide how to take the medicine in futu…

This study tested how well vitamin A is absorbed from fortified bouillon cubes compared to an oil-based supplement. Fifty-eight healthy women consumed different vitamin A formulations in broth, and researchers measured vitamin levels in their blood. The goal is to see if adding v…

This study looked at whether a 12-week exercise program designed around students' personal interests (like team games or fitness challenges) could help them exercise more regularly and improve their physical fitness compared to standard physical education. Over 500 college studen…

This study looked at how two drugs—Roflumilast (used for COPD) and Sitagliptin (used for diabetes)—affect blood sugar and gut hormones in 29 healthy adults aged 21-55. Participants took the drugs alone or together and had their blood tested after a meal. The goal was to understan…

This study tested two different versions of an inhaled drug (TPIP) in 42 healthy adults to see how much of the drug gets into the blood. Participants inhaled a single dose of each version on separate days. The results help researchers understand which formulation works better for…

This study looked at whether the experimental drug EB-1020 could be abused like other stimulants. It involved 80 healthy adults who occasionally use stimulants recreationally. Participants received single doses of EB-1020, a placebo (dummy pill), or d-amphetamine (a known stimula…

This early-stage study looked at how two drugs, epaminurad and C2406, affect each other in the body. It involved 18 healthy adults aged 19 to 50. The goal was to measure drug levels in the blood and check for any safety concerns.

This early-stage study tested the safety of a new drug, NAV-240, in 24 healthy adults. Participants received either the drug or a placebo to see what side effects might occur. The goal was to gather initial safety information, not to treat any disease.

This study checked if a dietary supplement made from silver fir branches, called Belinal®, is safe for the liver and kidneys. Fifteen healthy adults took the supplement daily for two weeks. Researchers measured blood markers of liver and kidney function at several points to see i…

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin, amoxicillin) and bismuth in 56 adults. Some participants were healthy and H. pylori-negative, while others had H. pylori infection. The goal was to measure drug levels…

This study tested how the drug risankizumab moves through the body when given by a prefilled pen compared to a traditional syringe. It involved 59 healthy adults and measured drug levels and side effects. The goal was not to treat a disease but to gather information for future us…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18 to 55. Participants took the drugs for several days and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels…

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men followed special diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers can reliably show ho…

This early-stage study tested a new drug called TAK-004 in 121 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as an injection under the skin. The study did not aim to treat any disease, but to gather important…

This study was the first time a new drug, VIS954, was given to humans. The main goal was to see if it is safe and how the body handles it. 54 healthy adults received either the drug or a placebo. Researchers monitored for side effects and measured drug levels in the blood.

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…