New pill for painful skin disease enters first human tests

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For participation in SAD20411/MAD20412: * Male and/or female participant, between 18 and 55 years of age, inclusive at the time of signing the ICF. * Appearing healthy by a comprehensive clinical assessment (detailed medical history and complete physical examination). For participation in MAD24339: * Age ≥18 and ≤65 years of age at the time of signing informed consent. * A diagnosis of HS made by a dermatologist at least 6 months prior to baseline visit. * HS lesions present in at least 2 distinct anatomic areas (e. g., left and right axilla; or left axilla and left inguino-crural fold), one of which must be Hurley Stage II or Hurley Stage III. * Total AN count of ≥4 at the baseline visit. - Draining tunnel count of ≤20 at the baseline visit. Exclusion Criteria: For participation in SAD20411/MAD20412: \- Any history or presence of clinically relevant cardiovascular, pulmonary, gastrointestinal, dermatologic, hepatic, renal, metabolic, hematological, neurological, osteomuscular, articular, psychiatric, systemic, ocular, gynecologic (if female) or signs of acute illness. Active or chronic infection requiring systemic treatment within 4 weeks prior to baseline. Known history of immunosuppression or suspected current immunosuppression. For participation in MAD24339: * Any active skin disease or condition other than HS (including but not limited to inflammatory skin diseases and cutaneous infections) that may interfere with assessment of HS. * Any active or chronic infection requiring systemic treatment (eg, antibiotics, antivirals, antifungals, antihelminthics) within 30 days prior to baseline. * Use of prescription topical therapies for the treatment of HS within 14 days prior to the baseline visit. - Treatment with systemic antibiotics for HS within 14 days prior to the baseline visit. - Non-biologic systemic therapies with potential therapeutic impact on HS \<28 days or five half-lives prior to baseline visit. * Any history of prior treatment with any systemic biologic with a potential therapeutic impact on HS. The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.