Your blood and stool could help scientists build better lab tests

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: 1. Aged 3-80 years. 2. Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 years). 3. Agree to allow biological samples to be stored for future research. 4. Willing to provide blood, stool, saliva, skin/mucosal/tonsil swabs, and/or skin punch biopsy specimens. EXCLUSION CRITERIA: Individuals meeting any of the following criteria will be excluded from study participation: 1. Pregnancy. 2. History of autoimmune or autoinflammatory disease. 3. Diabetes mellitus. 4. Cancer chemotherapy within the past 5 years. 5. Currently receiving treatment for an active malignancy. 6. Surgery within the past 8 weeks. 7. History of recent (within the past 30 days) infection. 8. History of significant, active parasitic, amebic, fungal, or mycobacterial infections within the past 5 years (as determined by the PI). 9. Infected with HIV and/or hepatitis B and/or C. 10. Use of an oral or inhaled glucocorticoid within the past 30 days. 11. History of a bleeding disorder. 12. Screening lab values are both outside of the NIH Department of Laboratory Medicine normal reference range and deemed clinically significant by the PI. 13. Receipt of an immunosuppressant or immunomodulatory drug within the past 30 days. 14. Receipt of a live-attenuated vaccine within the past 30 days. 15. Receipt of any other type of vaccine within the past 14 days. 16. Current or past use (within the past 90 days) of immunoglobulin therapy. 17. Current use of illicit drugs (per subject report). 18. Current use of nicotine-containing products, including cigarettes and chewing tobacco, nicotine patches, gum, electronic cigarettes, etc. 19. Current alcohol use disorders (criteria per Diagnostic and Statistical Manual of Mental Disorders, fifth edition). 20. Any condition that requires active medical intervention or monitoring to avert serious danger to the individual s health or wellbeing. 21. Any condition that, in the opinion of the PI, contraindicates participation in this study or would significantly affect immune profile. Co-enrollment guidelines: Participants may be co-enrolled in other studies. The PI may withdraw them from this study for any reason that may contraindicate participation.