Gut bugs may decide if your statin works
NCT ID NCT04098003
First seen Oct 31, 2025 · Last updated Jun 23, 2026 · Updated 35 times
Summary
This study looks at how the bacteria living in your gut might change the way your body responds to rosuvastatin, a drug used to lower cholesterol. Researchers will give healthy volunteers either the drug or a placebo for eight weeks and track changes in gut bacteria and cholesterol levels. The goal is to understand why some people respond better to statins than others.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
University of Pennsylvania
Phildelphia, Pennsylvania, 19104, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rosuvastatin (Crestor)
What this could lead to
If successful, this could help doctors predict who will benefit most from statins based on their gut bacteria.
What could go wrong
This is a small, early-stage study in healthy people, not patients. Results may not apply to those with high cholesterol or heart disease.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.