New liquid form of maribavir tested in healthy adults
NCT ID NCT04131556
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage study tested two liquid versions of the drug maribavir (used to treat certain viral infections) to see how well they are absorbed, how they taste, and if they are safe compared to the current tablet. The study involved 20 healthy adults, not children, to gather initial data. The goal is to eventually develop a child-friendly formulation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- maribavir
- What this could lead to
- If successful, this could lead to a child-friendly liquid version of maribavir, making it easier to give to children who need it.
- What could go wrong
- This is a very early (Phase 1) study in only 20 healthy adults, not children. The liquid formulations may not work as well or taste acceptable, and the study was terminated early, so results are limited.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
20 people
The number who actually took part.
- Started
-
Oct 2019
- Finished
-
Jan 2020
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 50 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * An understanding, ability, and willingness to fully comply with study procedures and restrictions. * Ability to voluntarily provide written, signed, and dated (personally or via a legally-authorized representative) informed consent/and assent as applicable to participate in the study. * Age 18-50 years, inclusive at the time of consent. * Male, or non-pregnant, non-breastfeeding female who agrees to comply with any applicable contraceptive requirements of the protocol or females of non-childbearing potential. * Healthy as determined by the investigator on the basis of screening evaluations. * Hemoglobin for males greater than or equal to (\> or =)135.0 gram per liter (g/L) and females \> or = 120.0 g/L at screening and on Day -1. * Body mass index (BMI) between 18.0 and 30.0 kilogram per meter square (kg/m2) inclusive with a body weight greater than (\>) 50 kg (110 lbs). Exclusion Criteria: * History of any hematological, hepatic, respiratory, cardiovascular, renal, neurological or psychiatric disease, gallbladder removal, or current recurrent disease. * Current or relevant history of physical or psychiatric illness, any medical disorder that may require treatment or make the participant unlikely to fully complete the study, or any condition that presents undue risk from the investigational product or procedures. * Known or suspected intolerance or hypersensitivity to the investigational product(s), closely-related compounds, or any of the stated ingredients. * Significant illness, as judged by the investigator, within 2 weeks of the first dose of investigational product. * Donation of blood or blood products (e.g., plasma or platelets) within 60 days prior to receiving the first dose of investigational product. * Within 30 days prior to the first dose of investigational product:a) Have used an investigational product, b) Have been enrolled in a clinical study (including vaccine studies) that, in the investigator's opinion, may impact this study, c) Have had any substantial changes in eating habits, as assessed by the investigator. * Confirmed systolic blood pressure \>139 millimetre of mercury (mmHg) or \< 89 mmHg, and diastolic blood pressure \> 89 mmHg or \< 49 mmHg. * Twelve-lead ECG demonstrating QTc \> 450 millisecond (msec). * Known history of alcohol or other substance abuse within the last year. * Male participants who consume more than 21 units of alcohol per week or 3 units per day. Female participants who consume more than 14 units of alcohol per week or 2 units per day. * A positive screen for alcohol or drugs of abuse at screening or on Day -1 of Treatment Period. * A positive human immunodeficiency virus (HIV), HBsAg, or Hepatitis C virus (HCV) antibody screen. * Use of tobacco in any form (e.g., smoking or chewing) or other nicotine-containing products in any form (e.g., gum, patch). * Routine consumption of more than 2 units of caffeine per day or participants who experience caffeine withdrawal headaches. * Prior screen failure, randomization, enrollment, participation in this study or participation in Part 1 of this study. * Current use of any prescription medication with the exception of hormonal replacement therapy. (Current use is defined as use within 30 days of the first dose of investigational product.) Current use of any over the counter medication (including herbal, or homeopathic preparations) within 14 days of the first dose of investigational product. * Current use of antacids and H2 antagonists. * Ingestion of known CYP3A modulators within 7 days of Day 1, Period 1. * Inability or unwillingness to consume 100 percent of high-fat meal in Part 2 (including participants with lactose or gluten intolerance). * History of oral/nasal cavity infections, gastroesophageal reflux, asthma treatment with albuterol, zinc supplementation. * Participants with dry mouth syndrome or burning mouth syndrome or menopausal women suffering from dysgeusia.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Healthy volunteers are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Clinical Pharmacology of Miami, Llc
Miami, Florida, 33014, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Scientists probe the nerve highways behind strength gains
- New syphilis test kits put to the test with donated blood
- Can a copy of a blockbuster arthritis drug match the original? scientists test it in healthy people
- Novo nordisk tests Brand-New molecule in humans for the first time
- New sedative candidate goes Head-to-Head with propofol in early human test
- Can a Room-Temperature dairy drink build muscle?