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Brain zapping study halted early: could it have helped heavy drinkers think more flexibly?

NCT ID NCT06634771

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single session of non-invasive brain stimulation (alpha-tACS) could change brain activity and help people break habits. Researchers compared the stimulation to a fake (sham) version in healthy adults and those with a history of heavy drinking. The study was terminated early and only enrolled 7 people, so no firm conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial alternating current stimulation (tACS)
What this could lead to
If successful, this could point toward a non-invasive way to improve behavioral flexibility, potentially helping people with addiction or impulse control issues.
What could go wrong
This was a very small, early-stage study that was terminated before completion. Results may not be reliable or generalizable. The intervention is experimental and not proven to work.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

7 people

The number who actually took part.

Started

Jul 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • 22-50 years old * Have a high school diploma or equivalent * Medically healthy * Fluent in English For RISK group only: * High risk alcohol use in the past month \[World Health Organization (WHO ) risk level 2-4\] * No history of adolescent binge drinking For RISK+ Adolescent binge alcohol (AIE) group only: * High risk alcohol use in the past month (WHO risk level 2-4) * High levels of adolescent alcohol use (4 or more binge drinking episodes before age 18) For Control (CON) group only: * Low risk alcohol use throughout the lifetime (WHO risk level 0-1) * No history of adolescent binge drinking * No lifetime history of Alcohol Use Disorder (AUD) Exclusion Criteria: * Any individual who meets one or more of the following criteria will be excluded from participation \[excluding positive breath alcohol concentration (BAC), urine drug screen, psychiatric diagnoses, and color blindness, all will be self-reported\]: * Lifetime history of a substance use disorder (SUD; including nicotine) but participants will not be excluded for an AUD. * Neurological disease such as dementia, seizures or head trauma * History of psychosis or psychotic episodes * Diagnosis of attention deficit hyperactivity disorder (ADHD) * Any systemic or inflammatory disease that could affect cognitive functioning (e.g., cancer, cardiovascular disease) * Any motor or visual disturbances that could hinder task performance (e.g., color blindness) * Use of psychoactive recreational drugs in the past month (excluding caffeine and alcohol) * Use of psychotropic medications in the past month including antidepressants, mood stabilizers, antipsychotics, anxiolytics, stimulants, or hypnotics (excluding antidepressant use when dosage has been stable for 1 month or longer) * Use of therapeutic brain stimulation \[e.g. transcranial magnetic stimulation (TMS) or electroconvulsive therapy (ECT)\] in the past month * Any history of brain surgery * History of migraine headaches * Pregnancy * Any brain implants or devices * First degree relative with primary epilepsy * Claustrophobia * Any magnetic resonance imaging (MRI) contraindication based on the University of North Carolina Biomedical Research Imaging Center's MRI safety checklist * Breath alcohol above 0.0% at time of session * Positive urine drug screen at time of session If a participant should have an exclusion criterion arise in the course of their participation (e.g. pregnancy or psychotic episode), their participation in the study will end unless the circumstances are transitory in nature (e.g. positive breath alcohol or urine drug screen).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of North Carolina, Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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