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Zapping a nerve in the forehead could reveal how brain and body talk

NCT ID NCT07662291

Knowledge-focused Sponsor: Xidian University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether stimulating a nerve in the forehead at different speeds changes how the brain and the body's automatic systems (like breathing and heart rate) work together. Twenty-five healthy adults will receive mild electrical pulses at 2Hz, 120Hz, or a fake (sham) stimulation while inside an MRI scanner. Researchers will watch brain activity and body signals to see which frequency has the strongest effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous trigeminal nerve stimulation (eTNS)
What this could lead to
If successful, this could help design better nerve stimulation therapies for conditions like anxiety, chronic pain, or heart rate disorders.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to people with medical conditions. The effects may be subtle or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy volunteers, aged 18 to 40 years old. 2. Right-handed. 3. Generally healthy with no history of neurological, psychiatric, or severe cardiovascular diseases. 4. Normal physical and neurological examinations. 5. Capable of understanding the study procedures and voluntarily signing the written informed consent form. Exclusion Criteria: 1. Contraindications to MRI scanning (e.g., claustrophobia, cardiac pacemakers, artificial cochlea, metallic braces, or any other ferromagnetic implants). 2. Female participants who are pregnant, lactating, or suspect they might be pregnant. 3. Contraindications to transcutaneous electrical stimulation (e.g., personal or family history of epilepsy/seizures, trigeminal neuralgia, facial skin lesions, or active skin diseases on the forehead). 4. Current or recent (within the past month) use of any medications known to affect the central nervous system or the autonomic nervous system (e.g., antidepressants, beta-blockers, sedatives, or sympathomimetics). 5. History of substance abuse, heavy smoking, or excessive daily consumption of alcohol or caffeine. 6. Irregular sleep patterns, shift work, or severe sleep deprivation within 24 hours prior to the scanning session.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fmri research Healthy volunteers

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Xidian University

    RECRUITING

    Xi'an, Shaanxi, 71000, China

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