National Institute On Alcohol Abuse And Alcoholism (niaaa)

This study looked at how consistent brain scans are when taken twice on the same day in healthy adults. Researchers used MRI and PET scans to measure brain connections and activity. The goal was to improve future studies of brain diseases. 112 healthy volunteers aged 18 and older…

This study tested a computer-assisted method for giving alcohol directly into the bloodstream through a vein, aiming to achieve precise blood alcohol levels for research. 229 healthy adults aged 21-45 who were social drinkers took part. Participants used a computer to self-admini…

This study used MRI scans to compare how the brain removes waste during sleep versus being awake. Researchers wanted to see if the brain's natural cleaning system is more active at night. Forty healthy adults aged 18 to 60 took part. The goal was to better understand how the brai…

This early-phase study tested whether nalmefene, a drug that blocks opioid receptors, changes how heavy drinkers' brains respond to alcohol-related cues and how much alcohol they choose to self-administer. Thirteen healthy heavy drinkers (over 15 drinks/week for women, 20 for men…

This study looked at whether people with alcohol dependence and/or early life stress have a harder time learning to feel calm after a scary experience. Researchers used brain scans and mild electric shocks to measure fear responses in 96 adults. The goal was to understand how gen…

This study looked at whether heavy drinking causes brain inflammation and how that might affect memory, attention, and thinking. Researchers used brain scans (PET and MRI) to measure inflammation and brain function in 74 adults with alcohol use disorder and healthy volunteers. Th…

This study looked at how heavy opioid use changes dopamine, a brain chemical that affects pleasure and self-control. Researchers compared people with opioid use disorder (some on medication, some not) to healthy volunteers. They used brain scans and thinking tests to understand t…

This study looked at how sleep affects the brain's ability to clear out waste products, specifically amyloid-beta, which is linked to Alzheimer's disease. Twenty-two healthy adults stayed overnight in a clinic twice—once sleeping normally and once staying awake all night. Researc…