National Institute On Alcohol Abuse And Alcoholism (niaaa)

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This early-stage trial is testing whether alirocumab, a drug approved for high cholesterol, is safe for heavy drinkers and might reduce liver inflammation. One hundred healthy adults who drink heavily will receive either alirocumab or a placebo injection over 8 weeks. Researchers…

This study is testing whether apremilast (Otezla), a drug currently used for psoriasis and arthritis, can reduce alcohol cravings in people with moderate to severe alcohol use disorder. Researchers will compare two different doses of the drug against a placebo in 100 adults who w…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This study aims to develop better brain imaging methods to understand how addiction affects the brain. Healthy adults aged 18 and older will undergo MRI scans, EEG, and other tests while performing simple tasks. The goal is to improve the reliability of these imaging techniques f…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study looks at how a gene called ZIP8 influences alcohol drinking and its effects on the brain. Healthy volunteers aged 21 to 60 of European ancestry will receive alcohol through an IV and can choose how much to take. Brain scans and questionnaires will help researchers unde…

This study looks at whether the artificial sweetener sucralose (found in many diet drinks and foods) changes how the body absorbs and processes certain medications. Researchers will give 150 healthy, overweight Black and Hispanic women either sucralose or a placebo capsule for 28…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at how a specific nicotine receptor gene (CHRNA5) influences people's response to alcohol. Healthy adults aged 21-60, both smokers and non-smokers, will receive alcohol through an IV or drink it, while researchers measure their brain activity using MRI and track …

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can change how the brain responds to alcohol-related cues in people with alcohol use disorder (AUD). Researchers will use brain scans to measure dopamine activity in healthy volunteers and people w…

This study investigates whether differences in taste and smell perceptions affect food choices and eating behaviors in people with and without obesity. Researchers will compare measures of taste, smell, and eating habits between the two groups, along with genetic, inflammatory, a…

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study tracks 1,500 people over two years to see how the COVID-19 pandemic has changed their drinking habits and related stress. Participants complete surveys about alcohol use, stress, and well-being, comparing before and during the pandemic. The goal is to understand the pa…