Cannabis compounds may rewire memory retrieval, brain scans suggest
NCT ID NCT07679581
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study investigates how THC and CBD in cannabis affect recognition memory in healthy adults who use cannabis regularly. Participants perform a memory task after smoking cannabis and on a separate sober day, while their brain activity is recorded via EEG. Blood samples measure THC and CBD levels. The goal is to understand how different cannabis strains influence memory processes like familiarity and recollection.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cannabis (smoked flower)
- What this could lead to
- If successful, this could clarify how different cannabis compounds affect memory, guiding safer use or therapeutic applications.
- What could go wrong
- This is a small, early-stage observational study in healthy regular users, so results may not apply to occasional users or people with memory disorders.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 64 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Community sample of healthy, regular cannabis users in the Boulder/Denver areas.
- Ages
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21 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. Must be between the ages of 21 and 40 and provide informed consent; 2. Must be right-handed (Laterality Quotient \> 60 on Edinburgh Handedness Inventory - Short Form136); 3. Heavy users (HU) in Experiments 1, 2, 3, and 4: 1. Must use cannabis at least 4 days during the month; 2. Must be a cannabis user for at least a year; 4. Non-users (NU) in Experiment 2: 1. Must not have used cannabis for prior 6 months; 2. Must have at least one episode of lifetime cannabis use; 5. Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening; 6. Must not test positive on a urine toxicology test for drugs of abuse at the Baseline Appointment (TDS); 7. Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days; ADHD medications, even extended-release forms, are short acting and medication" holidays" (e.g., on weekends and holidays) are routine in individuals prescribed ADHD medications, without adverse effects. 8. Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless); 9. Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours; 10. Must have a breath alcohol level of 0 at screening (to sign consent form); 11. Must not be actively seeking or in treatment for any substance use disorder (drug use levels will be carefully monitored via Timeline Follow Back (TLFB) throughout the study to assess any confounding influences of drug or alcohol use; 12. Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test \& screening form administered at Baseline); 13. Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders; 14. Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording. 15. Participants in Experiment 4 a. Must not have participated in Experiment 3
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Center for Innovation and Creativity (CINC)
RECRUITINGBoulder, Colorado, 80301, United States
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