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Could a glass of Alcohol-Free wine boost your brain?

NCT ID NCT05541887

Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of brain and mood tests. Researchers will also measure blood markers related to stress, inflammation, and brain chemicals to understand how the polyphenols might work.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dealcoholized muscadine wine polyphenols (a beverage with less than 0.5% alcohol)
What this could lead to
If it works, this could point toward a natural dietary approach to support brain health and emotional well-being in older adults.
What could go wrong
This is a small, early-stage trial with only 25 participants, so results may not apply broadly. The effects could be modest, and the beverage is not a treatment for any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy * BMI (18.5-29.9) * Body weight ≥110 pounds Exclusion Criteria: * Pregnancy * Breast-feeding * Smokers * Diabetic * Heavy drinkers * Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score \<26), * Inability to understand the cognitive function tasks * Intake of medication that might influence the outcome of the study (e.g. psychostimulant) * cannabis product user * Clinically diagnosed mental illnesses * Cardiovascular and neurological disorders * Uncontrolled hypertension

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Cognitive performance MEMORY MOOD

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Food Science and human nutrition department at University of Florida

    Gainesville, Florida, 32611, United States

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