Could LSD help curb heavy drinking? new trial investigates
NCT ID NCT05474989
First seen Apr 29, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and brain changes over 30 weeks.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospital of Psychiatry, University of Basel
RECRUITINGBasel, Switzerland
Contact
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University Hospital of Psychiatry, University of Bern
RECRUITINGBern, Switzerland
Contact
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LSD (lysergic acid diethylamide)
What this could lead to
If successful, this could provide a new treatment option to help people with alcohol use disorder reduce heavy drinking.
What could go wrong
This is a mid-stage trial with only 128 participants, so results may not apply to everyone. LSD can cause intense psychological effects, and the study is still recruiting.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.