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Can cannabis calm a sleep-deprived, anxious brain? new study aims to find out.

NCT ID NCT07656350

Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep. Researchers will measure skin conductance to see how their nervous system reacts to mild electric shocks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
THC and CBD oils
What this could lead to
If successful, this could help explain how cannabis-based products affect the body's stress response after poor sleep, pointing toward future treatments for anxiety or sleep disorders.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. It is designed to measure physiological changes, not to test a treatment. Results may not apply to people with clinical anxiety or sleep conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18-60 2. Currently experiencing higher than average anxiety (measured by a score of ≥10 on the GAD-7) 3. Able and willing to restrict their sleep to 4 hours on one occasion 4. Willing to restrict alcohol and recreational drug intake during time on the study, confirmed by negative urine drug screen on the day of the experimental session 5. Own a functioning phone and be able to respond to text messages 6. Willing to provide GP details 7. Willing to provide an emergency contact 8. Able to provide written informed consent 9. Willing to use a highly effective contraceptive method (see Section 5.2.2) for the duration of the study. Exclusion Criteria: 1. Currently receiving any treatment for any psychiatric disorder (medication and/or professional psychotherapy for a mental disorder) 2. Any cannabinoid use in the past 3 months, including CBD oil, medical cannabinoids or recreational cannabis/THC use 3. Cannabinoid contraindications: lifetime history of psychosis, 1st degree relative with psychosis, lifetime substance use disorder (that was professionally treated) 4. History of consistent (\>12 months) monthly cannabis use 5. Currently experiencing insomnia or irregular sleep pattern (e.g. night shift work) 6. Sleep restriction contraindications (sleep apnoea, sleep movement disorder, night shift work, insomnia) 7. Have excessive daily caffeine intake (\>4 cups of coffee per day or equivalent) 8. Unlikely to be able to complete the study procedures for any reason, as judged by the study team 9. Currently pregnant or lactating 10. Currently trying to conceive a child Additional criteria which must be met on experimental visits: 1. Negative urine drug screen 2. Negative urine pregnancy test 3. Negative alcohol breath test

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Conditions

The condition(s) this trial relates to.

anxiety disorder cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Centre for Mental Health Research and Innovation

    RECRUITING

    London, London, SE5 8BB, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.