King's College London

This study tests if taking capsules containing healthy donor stool (fecal transplant) can lower the risk of serious infections and hospital visits in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the real treatment…

This study is testing whether a special snack rich in plant nutrients and fiber can improve common menopause symptoms like hot flashes, night sweats, mood changes, and sleep problems. About 20 women aged 40-55 who are not on hormone therapy will eat the snack or a placebo daily f…

This study explores whether a structured dance and movement program is practical and helpful for adults with Functional Neurological Disorder (FND), a condition where the brain doesn't send proper signals to the body. Researchers will compare dance therapy to regular physical exe…

This study tests whether a digital therapy called SloMo can help people with psychosis who feel paranoid. SloMo teaches users to slow down fast thinking and reduce worry. About 150 people will receive the therapy from NHS therapists, and researchers will check if it is safe, effe…

This study tests whether opening blocked heart arteries with stents can improve quality of life for people with a type of heart failure called HFpEF. 350 participants will be randomly assigned to receive either a real stent or a placebo procedure, and neither they nor their docto…

This study looks at whether minocycline, an antibiotic that also fights inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if the approach is practical and acceptable for 35 participants. The goal i…

This study tests whether a safe, non-invasive brain stimulation device (tDCS) used at home can reduce depressive symptoms in people with bipolar disorder. 212 adults with bipolar depression will receive either real or sham stimulation for 10 weeks. The goal is to see if this easy…

This study tests whether a gentle brain stimulation device used at home can help ease depression symptoms. About 438 adults with major depression will either receive the stimulation plus their usual care, or usual care alone. The goal is to see if this safe, non-invasive treatmen…

This study tests a smartphone app called Orbi, which uses cognitive behavioral therapy (CBT) techniques to help people with long-term physical health conditions manage feelings of distress, anxiety, or depression. About 60 adults in the UK will use the app plus usual charity supp…

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, mood, and blood sugar control in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires, and wear a continuous gluco…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests whether adding a special heat treatment (water-filtered infrared-A, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancers that cannot be cured. About 60 adults will receive the combi…

This study follows 250 teens with ADHD (ages 16-17) for two years using smartphone apps and a Fitbit to track symptoms, sleep, activity, and mood. The goal is to understand what changes happen during this critical transition and to design a new app that helps young people manage …

This study compares brain energy use, lactate, and glutamate levels between 75 people with schizophrenia and healthy volunteers. Participants undergo MRI and PET scans to measure brain activity and chemistry. The goal is to better understand how the brain works in schizophrenia, …

This study looks at how to better identify early signs of chronic venous insufficiency (CVI) in people with dark skin tones, who are often underdiagnosed. Researchers will interview patients about their experiences and test new assessment techniques, including touch and special p…

This study looks at whether diroximel fumarate, a drug already used for multiple sclerosis, can increase glutathione—a key antioxidant—in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the drug …

This study takes small samples of breast cancer that has spread to the brain or other organs and grows them in the lab as mini-tumors (organoids). Researchers will test whether these mini-tumors can predict how well a patient's cancer responds to treatments like chemotherapy or r…

This study looks at whether regular skin massage in healthy babies (up to 6 months old) changes immune signals in the skin. Researchers will compare daily massage, twice-weekly massage, and no massage over 8 weeks. The goal is to understand how touch might influence early immune …

This study will follow 5,000 people who are getting a new type of device to treat a brain aneurysm. The goal is to see how safe and effective these devices are, and to find out what factors might make an aneurysm come back after treatment. Researchers will look at things like smo…

This study is testing whether pregnant people at risk of depression will use a mobile app called HappyMums to track their mental health. The app collects data through questionnaires and phone usage. Researchers hope this information can help predict and identify antenatal depress…

This study tests whether a brief online video about cannabis withdrawal can help daily users become more aware of their cannabis use. Researchers will recruit 100 adults who use cannabis at least 25 days per month. Participants will watch either an educational video on withdrawal…

This early study tests if a special ultrasound contrast agent (microbubbles) can measure pressure inside the heart without using a catheter. Ten adults with suspected heart disease will receive the contrast agent and have their heart scanned. Researchers will compare the microbub…

This study looks at how eating more plant foods changes the bacteria in your gut and affects your heart health. Healthy adults aged 30-70 will replace all their meals with study-provided plant-based foods for 4 weeks. Researchers will measure gut bacteria, blood, urine, and arter…

This study is collecting blood samples, brain wave data, and medical history from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe, and North America. Researchers will compare this information with data from 2000 people without the condition. The goal…

This study looks at children and teens (ages 12-17) who have a parent with autosomal dominant polycystic kidney disease (ADPKD). Researchers want to find out how many of these young people have high blood pressure and early signs of the disease. Participants will get an MRI, gene…

This study looks at how the immune system might play a role in psychotic symptoms and how well antipsychotic medications work. Researchers will collect blood and spinal fluid from 500 people with psychosis who are starting or changing medication, plus a healthy comparison group. …