King's College London

This study is for people who have chest pain and shortness of breath but no blockages in their main heart arteries. The likely cause is a problem with the heart's tiny blood vessels, called coronary microvascular dysfunction (CMD). The study will test treatments tailored to how e…

This study tests a new, less invasive cleaning method called MINST for treating peri-implantitis, an infection around dental implants that can cause bone loss and implant failure. Researchers will compare MINST to the standard cleaning method in 80 adults with the condition. The …

This study tests a talking therapy called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. The therapy includes motivational interviewing and cognitive behavioral therapy in weekly sessions over 12 weeks. Researchers…

This study tests whether a modified high-fiber version of the UK's EatWell diet can improve health markers linked to early-onset colorectal cancer. Two hundred adults in the UK will follow either the standard EatWell diet (30g fiber/day) or a modified version (40g fiber/day) for …

This study tests a new therapy that combines face-to-face sessions with virtual reality (VR) to help people with psychosis manage their emotions. Participants will practice emotion regulation skills in realistic VR scenarios with live coaching from a therapist. Fifteen people wit…

This study tests whether a short virtual reality (VR) program is safe and acceptable for adults with anorexia nervosa. Participants will use VR for about 20-30 minutes each weekday for one week, while continuing their usual care. The goal is to see if people are willing to try it…

This study will give 4,400 adults with anxiety a digital brain training program called LENS, which helps people think more positively in uncertain situations. Researchers want to find out why some people improve more than others by looking at genetic and psychological factors. Th…

Researchers at King's College London are studying what happens in the brain when people hear voices or sounds others cannot hear, known as auditory hallucinations. The study compares people with schizophrenia, schizoaffective disorder, or related psychotic conditions to people wi…

This project at King's College London asks how hospital outpatient departments can work better for people with neurofibromatosis who also have sensory challenges. About 30 patients, carers, and staff from Guy's and St Thomas' NHS Foundation Trust take part in interviews, observat…

Researchers at King's College London are studying how the immune system relates to neuropsychiatric symptoms, which include mental and neurological issues. They will compare blood and spinal fluid samples from people with such symptoms against samples from healthy controls. The g…

This study explores whether inflammation in the body is linked to the mood and psychological symptoms of Premenstrual Dysphoric Disorder (PMDD). Researchers will compare women with PMDD to healthy controls, tracking daily emotions and behaviors over two menstrual cycles and takin…

This observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…

This study looks at how foot care is currently handled in care homes for older adults. Researchers will survey care staff and interview residents, families, and managers to understand what people know and do about foot health. The goal is to find gaps and opportunities to improve…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study aims to create a patient decision aid for young people aged 11-18 who are missing one or both upper front teeth, a condition affecting 1 in 50 people. Researchers will interview patients and their parents, and hold focus groups with clinicians, to understand what matte…

This study looks at brain activity recorded from deep brain stimulation (DBS) devices in 20 people with Parkinson's disease. Researchers want to see if certain brain signals are linked to symptoms like sudden anxiety, impulse control problems, and hallucinations. Participants wil…

This study follows 1,000 pregnant women and their partners from early pregnancy to about two months after birth. Participants fill out short questionnaires at key timepoints to track how their health information needs change. Some may also share data from their smartphones or wea…

This study looks at whether cannabidiol (CBD) can reduce the amount of THC heavy cannabis users need to feel intoxicated. About 30 adults who use cannabis heavily will take a single dose of CBD or a placebo, then inhale THC using a vaporiser and decide when they've had enough. Re…

This study will watch and interview maternity clinicians (midwives and obstetricians) to understand how they decide whether to use medical interventions during childbirth. About 200 clinicians will take part. The goal is to learn the reasons behind their choices, not to test a tr…

This study tests a questionnaire called POSITIVE OUTCOMES to help doctors focus on what matters to people living with HIV, like mental health and social concerns. About 17,000 adults from five clinics in the UK and US will try it out. The goal is to see if using this tool improve…

Healthspan Connect is a new research programme aiming to understand what helps people stay healthy as they age. It will recruit 100,000 participants aged 12 and older across the UK, using digital tools and home-based sample collection. The study will explore how lifestyle, enviro…