CBD may help heavy cannabis users use less THC
NCT ID NCT07471347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether cannabidiol (CBD) can reduce the amount of THC heavy cannabis users need to feel intoxicated. About 30 adults who use cannabis heavily will take a single dose of CBD or a placebo, then inhale THC using a vaporiser and decide when they've had enough. Researchers will measure how much THC they use, along with mood, thinking, and physical effects, to better understand cannabis tolerance.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults, between 18 and 45 years old 2. Heavy and frequent cannabis user: using 7-14 grams of high potency cannabis per week over the past month, and using cannabis on at least 5 days per week over the past month 3. Positive urine drug screen (UDS) for cannabis 4. Willing to abstain from cannabis use for 4 hours before any experimental session. 5. Willing to eat two non-vegan full-fat yoghurts to aid drug absorption 6. Providing written informed consent. Exclusion Criteria: 1. Dependent use of alcohol or illicit drugs (apart from cannabis or tobacco/nicotine) 2. Not able to provide a UDS which is negative for illicit drugs (apart from cannabis) 3. Not able to provide a negative alcohol breath test 4. Personal or family history (first-degree) of psychosis or mania 5. Currently prescribed antidepressant, mood-stabilising, antipsychotic or stimulant medication, or regular medication for a significant medical condition (e.g. antihypertensives, anticonvulsants, anticoagulants, or immunosuppressants) 6. Diagnosis of a major medical or psychiatric illness that the study doctor considers inappropriate for the purposes of this study 7. Female participants who are pregnant or mothers who are lactating 8. Not willing to use an adequate form of contraception for the duration of the study 9. Participant in another experimental medicine study or clinical trial within the past three months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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King's Clinical Research Facility
London, United Kingdom
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Other studies related to the condition(s) this trial covers.
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