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New gentle cleaning technique could save failing dental implants

NCT ID NCT07365722

Disease control Sponsor: King's College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new, less invasive cleaning method called MINST for treating peri-implantitis, an infection around dental implants that can cause bone loss and implant failure. Researchers will compare MINST to the standard cleaning method in 80 adults with the condition. The goal is to see if MINST leads to better healing, less pain, and fewer deep pockets around the implant after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
minimally invasive non-surgical therapy (MINST) - a precise cleaning procedure
What this could lead to
If it works, this could offer a more effective and less painful way to treat peri-implantitis, potentially reducing the need for surgery and helping people keep their dental implants longer.
What could go wrong
This is an early-stage trial with only 80 participants, so results may not apply to everyone. The new method might not be significantly better than the current standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of peri-implantitis (any implant surface/any amount of keratinized gingiva) * PPD\>6mm at least in one implant surface * Bone levels ≥3mm apical of the most coronal portion of the intra-osseous part of the implant. * Implant surface deemed accessible by the treating clinician, without the need to remove the prosthetic suprastructure * Full-mouth plaque score \<30% * Full-mouth bleeding score \<30% Exclusion Criteria: * A course of antibiotics within the past 3 months * Pregnant/lactating women * Relevant medical history as evaluated by the examining clinician which may have the potential to affect periodontal surgical treatment (e.g., uncontrolled diabetes HbA1c≥7). * Individuals on long-standing (2 or above years) supportive peri-implant care (SPIC) * Previous non-surgical or surgical therapy of the affected implant within 12 months * Current smoking or vaping (defined as any smoking or vaping within 12 months) * Implant considered hopeless according to the treating clinician (e.g. mobility, circumferential bone loss \>80%, implant outside the bone envelope) * Case needing adjunctive antibiotic therapy, according to the treating clinician

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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