Brain scans reveal why social life suffers in alcohol addiction
NCT ID NCT07464613
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect daily social interactions and the risk of relapse after treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. AUD patients Inclusion criteria: * Patients between 18 and 65 years old, men or women, right-handed, following AUD treatment as inpatients or outpatients and currently abstinent * Having a diagnosis of severe alcohol use disorder according to DSM-5 criteria * Native French speakers * Patients enrolled in the national healthcare insurance program * Patients consenting to participate in the study Exclusion criteria: * A diagnosis of schizophrenia, of any other chronic psychotic state, or of bipolar disorder according to DSM-5 criteria * The presence of a current depressive episode as defined by DSM-5 criteria * The presence of another moderate or severe substance use disorder according to DSM-5 criteria, except for tobacco and cannabis if alcohol is the primary substance consumed and the criteria for cannabis dependence are not met * The presence of a neurodevelopmental disorder * The presence of any clinically significant or unstable pathology: organic pathology affecting the central nervous system or disease likely to interfere with assessments, including the neurological complications of alcoholism * Having any uncorrected auditory or visual deficits * Contraindication to the use of MRI * Individuals particularly protected by the law * No smartphone with Apple or Android operating system 2. Healthy control participants: Inclusion criteria: * Participants between 18 and 65 years old, men or women, right-handed * Native French speakers * Participants enrolled in the national healthcare insurance program * Participants consenting to participate in the study Exclusion criteria: * A diagnosis of schizophrenia, of any other chronic psychotic state, or of bipolar disorder according to DSM-5 criteria * The presence of a current depressive episode as defined by DSM-5 criteria * The presence of substance use disorder as defined by DSM-5 diagnostic criteria, except for tobacco dependence * Having any first-degree relative with alcohol use disorder according to DSM-5 diagnostic criteria * The presence of a neurodevelopmental disorder * The presence of any clinically significant or unstable pathology: organic pathology affecting the central nervous system * Having any uncorrected auditory or visual deficits * Contraindication to the use of MRI * Individuals particularly protected by the law * No smartphone with Apple or Android operating system
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chu Reims
RECRUITINGReims, Reims, 51092, France
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