Phone app could stop PTSD and pot addiction after assault
NCT ID NCT05989841
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a smartphone-based program called RISE Guide for women who have just been sexually assaulted. The goal is to see if it can reduce anxiety sensitivity and prevent posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD). 68 women who seek emergency care within 72 hours of an assault and use cannabis at least once a week will use the app for 9 weeks. Researchers will measure changes in anxiety and cannabis-related problems.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- RISE Guide (a smartphone-based cognitive behavioral therapy program)
- What this could lead to
- If it works, this could provide a practical, scalable way to prevent PTSD and cannabis use disorder in women after sexual assault.
- What could go wrong
- This is an early Phase 1/2 trial with only 68 participants, so results may not apply to everyone. The intervention is new and may not be effective for all.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 68 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Women sexual assault survivors presenting for emergency care \<72 hours post-assault at 1 of our 4 emergency care sites 2. English speakers 3. 18+ years of age 4. Able to provide informed consent 5. Have a smartphone with continuous service \>1 year 6. Report \>1x/weekly cannabis use on a substance use screener 7. Report elevated AS (\>17 on the Anxiety Sensitivity Index-3) Exclusion Criteria: 1. Inability to provide informed consent (e.g., serious injury preventing the ability to hear, speak, or see to consent and participate, or other causes (e.g., diagnosed cognitive deficits, diagnosed dementia, asleep at time of screening)). 2. Prisoner 3. Currently pregnant 4. Lives with assailant and plans to continue to do so 5. Admitted patient 6. No mailing address 7. Previously enrolled 8. No sexual assault nurse examiner (SANE) examination 9. Reporting current plan and intent for suicide or homicide 10. Does not understand written and spoken English
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
6 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Harbor Shelter
RECRUITINGSmithfield, North Carolina, 27577, United States
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Hennepin Assault Response Team
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55415, United States
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SAFE Austin
RECRUITINGAustin, Texas, 74103, United States
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Tulsa Forensic Nursing
NOT_YET_RECRUITINGTulsa, Oklahoma, 74103, United States
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UNC Chapel Hill
NOT_YET_RECRUITINGChapel Hill, North Carolina, 27599, United States
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University Medical Center
NOT_YET_RECRUITINGLas Vegas, Nevada, 89102, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI decode how trauma therapy heals?
- Can a Two-Day couples retreat ease PTSD?
- Can a website help people cut back on cannabis?
- Can community health workers help trauma survivors heal?
- Brain scans probe why cannabis hits men and women differently
- Can rewards and remote coaching help people cut back on cannabis?