CANNABIS USE DISORDER

This study tests if semaglutide, a medicine used for diabetes and weight loss, can help adults with cannabis use disorder use less cannabis. About 100 people will get either semaglutide or a placebo for 20 weeks. The main goal is to see if the drug reduces total cannabis use comp…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder reduce their cannabis use. Twelve adults will receive two psilocybin sessions with psychological support over 12 weeks, with follow-ups at 3 and 6…

This study tests whether cannabidiol (CBD), a non-psychoactive compound from the cannabis plant, can help people who regularly use high-potency cannabis concentrates reduce their use and cravings. About 120 adults aged 25-60 who use cannabis concentrates at least 4 times a week b…

This study is testing a new, non-invasive brain stimulation technique called rTMS to help people with cannabis use disorder reduce their use. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is practic…

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will get either the drug or a placebo, plus counseling. All visits are done remotely.

This study tests a new therapy called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines two proven approaches—12-step support and motivational therapy—to see if it helps teens stay abstinent longer and reduce substance-related problems. About 294 par…

This study looks at what happens when adults with cannabis use disorder cut back on cannabis. Over 8 weeks, participants get counseling, computer-based therapy, and financial rewards for reducing use. Researchers will track changes in sleep, thinking, cannabis-related problems, a…

This study tests whether hemp-derived CBD can help young adults (ages 18-25) who use cannabis at least 5 days a week reduce their cannabis use and related harm. Participants are not trying to quit and will take either CBD or a placebo for 8 weeks. The study measures changes in ca…

This study tests a smartphone program designed to reduce anxiety sensitivity—a known risk factor—in women who have recently experienced sexual assault. The goal is to prevent the development of posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD). Researchers will…

This study aims to help people who use cannabis daily and have trouble handling stress. Researchers are testing a one-session computer program with smartphone reminders to see if it can reduce stress-related cannabis use. About 80 participants with cannabis use disorder will be r…

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app helps reduce depressive feelings and cannabis use, and if p…

This study tests a brief virtual therapy called Action-Based Cognitive Remediation (ABCR) to help young people (ages 16-30) with early psychosis reduce their alcohol and cannabis use. The therapy involves 16 sessions over 2 months and aims to improve thinking skills that support …

This early-stage trial tests a generative AI chatbot called Therabot-CALM to see if it is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen adults will use the app for 4 weeks and give feedback through interviews and surveys.…

This study tests whether a one-month program of 20 home-based brain stimulation sessions, combined with guided mindfulness meditation, can help adults aged 22-65 who want to reduce their cannabis use. Participants will be randomly assigned to receive either real or sham stimulati…

This study compares two brief counseling programs for young adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions one week apart and complete follow-up surveys and saliva tests over six months. The goal is to see…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will use brain scans to measure changes in brain chemicals and activity related to reward. The goal is to understand these differen…

This study looks at whether suvorexant (Belsomra), a drug approved for insomnia, can lower brain activity related to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug chan…

This study looks at how the brain's reward system changes when teenagers with cannabis use disorder stop using cannabis for 6 weeks. Researchers will use brain scans (fMRI) to compare teens who quit with those who keep using and with teens who never used cannabis. The goal is to …

This study is for 400 adults with alcohol or cannabis use disorder who are willing to try group therapy. Researchers will measure thinking skills, motivation, and emotions before and during 12 weeks of cognitive behavioral therapy. The goal is to better understand how these facto…

This study tests whether a saliva (oral fluid) test can accurately show if a person has used cannabis recently, all done from home. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples and report t…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers want to understand how these br…

This study looks at how young adults aged 18-25 with cannabis use disorder react to stress differently based on their sex. Researchers will measure withdrawal symptoms, stress responses, and how soon people return to cannabis use after a short break. The goal is to learn more so …

This study looks at how stress influences the urge to use cannabis in people with Cannabis Use Disorder. Researchers will give participants drugs that mimic stress and measure their brain activity, cravings, and blood levels of natural cannabinoids. The goal is to understand the …

This study looks at whether brain cell connections in the memory center improve after people with cannabis use disorder stop using cannabis for at least 4 weeks. Researchers will compare these changes to healthy volunteers and test memory performance. The goal is to understand ho…

This study looks at whether brain activity related to learning can predict how well teens (ages 14-17) respond to a program aimed at reducing cannabis use. Participants get a brain scan, then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…