Can magnetic pulses curb cannabis cravings? new study aims to find out
NCT ID NCT05859347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new type of brain stimulation (rTMS) as a treatment for cannabis use disorder. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is safe, tolerable, and can reduce cravings and use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 46 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2023
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Must be deemed to have capacity to provide informed consent 2. Age between 18 to 65 3. Diagnosis of cannabis use disorder according to the DSM-5 and the Structured Clinical Interview for DSM-5 (SCID for DSM-541) 4. Report cannabis as the primary drug of concern, a frequent pattern of use (≥5 days per week), and a goal of reduction or abstinence of cannabis use 5. CUDIT-R score ≥12 6. Marijuana Contemplation Ladder ≥7 7. Cannabis positive urine drug screen, with Narcochek baseline THC-COOH level of \>150 ng/ml. 8. On a stable regimen of their psychotropic medications for 14 days before enrolment. Exclusion Criteria: 1. Pregnant or intending to be pregnant during the study 2. Diagnosis of bipolar disorder, schizophrenia spectrum disorder, or other active concurrent psychiatric disorder that is too unstable and may preclude safe participation in the trial as deemed by the PI. 3. Substance use disorder other than cannabis or nicotine, that is of moderate severity or greater, or is the primary substance of concern based on the SCID for DSM-5 4. Known active seizure disorder, significant head injury with an imaging verified lesion 5. Unstable medical illness 6. Presence of cardiac pacemaker, intracranial implant, or metal in the cranium 7. Participants taking \> 2 mg lorazepam (or a benzodiazepine at an equivalent dose) or taking any anticonvulsant medication during treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre for Addiction and Mental Health
RECRUITINGToronto, Ontario, M6J 1H4, Canada
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Other studies related to the condition(s) this trial covers.
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