Centre For Addiction And Mental Health

This study tests whether metformin, a diabetes medication, can help adults with intellectual disability who have gained weight from antipsychotic drugs. About 100 participants will receive either metformin or a placebo for several months. The goal is to see if metformin leads to …

This study tests whether magnetic seizure therapy (MST) can safely reduce symptoms in people with schizophrenia that hasn't improved with standard medications. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST, which uses magnetic…

This study is testing a personalized approach to therapy for 60 youth (ages 13–23) who have bipolar disorder or a close family member with it. Instead of a one-size-fits-all treatment, participants receive different levels of DBT (a type of talk therapy) based on their needs. The…

This study is testing a new, non-invasive brain stimulation technique called rTMS to help people with cannabis use disorder reduce their use. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is practic…

This pilot study tests a personalized brain stimulation treatment for people with severe addiction who haven't been helped by other treatments. Ten participants will first undergo detox, then have temporary electrodes placed in their brain to map addiction-related areas, followed…

This study looks at whether taking antipsychotic medication every other day is just as effective as taking it daily for people with schizophrenia. The goal is to see if the extended dosing schedule can reduce side effects while keeping symptoms under control. About 120 adults wil…

This study looks at whether extra therapy sessions (called boosters) help young people aged 14 to 26 who have or are at risk for bipolar disorder. Participants have already completed one year of dialectical behavior therapy (DBT) in a previous study. The goal is to see how often …

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study tests whether giving multiple brain stimulation sessions per day (accelerated) works better than one session per day (conventional) for treating depression in people aged 60 and older. All 280 participants will receive active treatment, but some get the faster schedule…

This study is testing whether a year of dialectical behavior therapy (DBT) can help young people aged 13 to 23 who have bipolar disorder or are at high risk for it. Participants will attend weekly skills training and individual therapy sessions to learn mindfulness, emotion contr…

This study tests a new therapy called A-EMDR, where people use eye movements on their own to help with PTSD and substance use. Researchers want to see if it reduces PTSD symptoms and drug or alcohol use over 4 weeks. The study involves 24 adults and compares A-EMDR to standard ca…

This study tests whether cannabidiol (CBD) can lower alcohol cravings and the amount people drink. Thirty-six adults with alcohol use disorder will take both CBD and a placebo at different times to compare effects. The goal is to see if CBD can be a new tool to help manage alcoho…

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who vape nicotine daily to cut back. Forty adults aged 18-65 who vape regularly will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes i…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely reduce depression in autistic youth aged 16–24. About 80 participants will receive either real or sham rTMS over several weeks. The goal is to see if this treatment, already used for depres…

This study tests a safe, painless brain stimulation method called tACS to see if it can improve working memory in people with mild cognitive impairment (MCI). Twenty adults aged 60 and older with MCI will receive 1-hour sessions, 5 days a week for 2 weeks. Researchers will measur…

This study tests if a type of brain stimulation called iTBS can reduce depression symptoms in people with bipolar disorder that hasn't improved with other treatments. About 124 adults will receive either real or fake (sham) stimulation daily for 30 days. Researchers will track mo…

This study tests whether a non-invasive brain stimulation technique called rTMS can help daily smokers quit. Researchers want to see if offering this treatment in a nicotine addiction clinic is practical and acceptable. About 40 participants will receive daily rTMS sessions for 3…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy is safe and tolerable for autistic adults with depression that hasn't responded to other treatments. Twenty participants will receive two doses (10mg and 25mg) al…

This study tests whether N-acetylcysteine (NAC), a safe antioxidant supplement, can reduce early psychosis-like symptoms in 90 people at clinical high risk for schizophrenia. Participants take NAC or a placebo for 8 weeks, and researchers measure changes in symptoms and brain act…

This study looks at why some people develop depression after a mild or moderate COVID-19 infection. Researchers will use brain scans to compare brain activity in 90 adults who have new depression after COVID-19. The goal is to better understand the brain changes involved, not to …

This study is for 400 adults with alcohol or cannabis use disorder who are willing to try group therapy. Researchers will measure thinking skills, motivation, and emotions before and during 12 weeks of cognitive behavioral therapy. The goal is to better understand how these facto…

This study explores whether a non-invasive brain stimulation technique called rTMS can improve motor function in autistic adults. Researchers think that overactive brain plasticity in the motor cortex may cause movement difficulties. They will test 150 autistic and non-autistic a…

This study looks at how smoking cannabis, tobacco, or both together affects driving skills, thinking, and blood THC levels. Sixty regular cannabis users will drive a simulator and take cognitive tests after smoking different combinations. The goal is to understand why people mix …

This study looks at how antipsychotic drugs change the way the brain responds to insulin in women, and whether this varies with menstrual cycle phase. Fifteen healthy women will receive the antipsychotic olanzapine or a placebo, plus insulin nasal spray, and undergo MRI scans. Th…

This study aims to understand why people with body dysmorphic disorder (BDD) see their appearance in a distorted way. Researchers will use brain scans, eye-tracking, and facial emotion recognition to measure how the brain processes faces. The goal is to build a model of these per…

This study looks at how cannabis affects driving in young (19-25) and middle-aged (35-45) adults. Half of the 128 participants will be occasional users, half frequent users. They will use a driving simulator to measure weaving and speed changes after cannabis use.

This study checks if an online cognitive assessment platform (Creyos) works as well as traditional paper-and-pencil tests for tracking memory and thinking changes in older adults. About 150 participants with mild cognitive impairment, remitted depression, or healthy aging will ta…

This study looks at whether a gentle brain stimulation technique called tDCS changes the number of connections between brain cells in people with schizophrenia. Researchers will use special PET scans to measure these connections before and after treatment. The goal is to better u…

This study looks at how haloperidol, an antipsychotic medication, may interfere with insulin's normal action in the brain. Insulin helps control blood sugar and supports brain function, but long-term use of haloperidol can lead to weight gain and diabetes. Researchers will give h…

This study aims to see if creating personalized profiles for children with disruptive behavior disorders and their parents can help predict which treatment works best. Researchers will assess psychological, emotional, and neuropsychological factors before treatment. About 200 chi…