Centre For Addiction And Mental Health

This study tests a non-invasive brain stimulation technique to improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. The goal is to strengthen brain connections in the frontal lobe to help people compens…

This study tests a structured care plan for treating agitation and aggression in people with Alzheimer's disease. The plan combines medications and non-drug approaches based on regular assessments. Researchers will compare this approach to usual care in 187 participants living in…

This 7-year study tests whether a combination of gentle brain stimulation (tDCS) and computer-based cognitive exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression who are at higher risk. Part…

This study is testing a home-based program designed to help prevent long-term memory decline in older adults at risk for Alzheimer's disease. The program combines brain-training exercises with a gentle, non-invasive brain stimulation technique called tDCS, which is delivered by a…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, given alongside psychotherapy can safely reduce symptoms in people with obsessive-compulsive disorder (OCD) that hasn't responded to standard treatments. Ten adults will receive two 25 mg d…

This pilot study tests a youth-friendly therapy called NECT-Y to see if it can reduce self-stigma in 96 young people with bipolar disorder or multiple mental health conditions. Participants will either join a 14-week virtual group therapy or continue their usual care. The main go…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, balance, and daily living skills in seniors with mental health conditions. About 270 participants living i…

This study was designed to see if online group therapy (CBT with mindfulness) works as well as in-person therapy for adults with major depression. It planned to include people with at least mild depression and compare changes in mood and anxiety. However, the study was withdrawn …

This study tests a brief 4-session psychological treatment for people with borderline personality disorder (BPD) who come to the emergency department with suicidal thoughts or self-harm. The goal is to see if this short therapy can reduce suicidal thinking, improve symptoms, and …

This study tests a telephone-based, computer-aided care program for adults with depression, anxiety, or risky drinking. Participants receive extra support from a Mental Health Technician who helps their primary care provider manage treatment. The goal is to see if this approach r…

This study looks at whether people with anorexia nervosa can learn to associate certain cues with positive feelings, like pleasure from food. Researchers will measure brain activity, heart rate, and pupil responses in 90 female participants aged 12-22. The goal is to understand h…

This study looks at why people with Alzheimer's disease become agitated or aggressive, and tests if a gentle brain stimulation technique called tDCS can help. Researchers will use magnetic pulses and brain wave recordings to understand brain changes in 90 participants, including …

This study aimed to test a 12-week program designed to improve mental well-being in young South Asian women aged 16-24 with mood or anxiety disorders. The program was culturally tailored to address their unique needs. However, the study was withdrawn before any participants were …

This study looks at whether a team-based care model can help youth aged 14-17 with mental health and addiction issues get faster, better care. About 247 teens will be randomly assigned to either the new team approach or usual care at hospital clinics in Toronto. The goal is to se…

This small study tests whether psilocybin, the active ingredient in magic mushrooms, can increase the number of connections between brain cells in people with mild memory problems. Ten participants (six with amnestic mild cognitive impairment and four healthy volunteers) will rec…

This study looks at whether Black, Indigenous, and People of Color (BIPOC) face more barriers to starting or sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects medication reco…

This study is testing whether a 12-week program that combines brain training, social activities, and exercise can help seniors with mental health conditions living in community housing. The program is delivered by a personal support worker and will be adjusted based on feedback f…

This study looks at how a non-invasive brain stimulation technique called paired associative stimulation (PAS) affects working memory in people with schizophrenia. Researchers will use brain scans (EEG) and memory tasks to measure changes over one week. The goal is to understand …

This study planned to test a digital health worker named PAHOLA that would deliver counseling to people who drink too much alcohol but face barriers to getting treatment. The goal was to see if talking to a computer-based helper could reduce drinking and improve health. However, …