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Brain zaps vs. brain zaps: which one helps veterans kick the habit?

NCT ID NCT07050862

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases and how brain activity changes. The goal is to find a more effective treatment option for tobacco use disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veteran * Individuals who smoke 10 or more cigarettes per day and have a CO level \> 10 ppm indicative of recent smoking * Those who have not received substance abuse treatment within the previous 30 days * Those who have been stable on psychotropic medications for at least three months * For females, those who test non-pregnant and use adequate birth control * Those who are willing to provide informed consent * Those who can comply with protocol requirements and likely complete all study procedures * Those who are motivated to quit smoking (based on responses of "very likely" or "somewhat likely" in the motivation questionnaire Exclusion Criteria: * Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria * Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia) * Contraindications to rTMS (history of a seizure or epilepsy) * A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain * History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment * Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea * Major Axis I disorders diagnosed according to DSM-V criteria, such as bipolar affective disorder, schizophrenia, dementia, or major depression * Regarding the Veteran population, the investigators will enroll smokers who have PTSD * Current use of other forms of nicotine delivery, such as nicotine patches or electronic cigarettes * Currently prescribed bupropion and/or varenicline

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Cessation substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RTMS Tabacco use disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ralph H. Johnson VA Medical Center, Charleston, SC

    RECRUITING

    Charleston, South Carolina, 29401-5703, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.