Alcohol-related disorders

This phase 2 trial tests an experimental drug called efimosfermin alfa in adults with alcohol-related liver disease. The study aims to see if the drug can improve liver health, measured by liver stiffness and a standard liver disease severity score. Participants receive either th…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This early-stage study tests whether the psychedelic drug DMT, combined with psychotherapy, can help people with alcohol use disorder. 63 participants will receive either a moderate or low dose of DMT, or a placebo, and their safety and desire to drink will be measured. The goal …

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo shot for 28 weeks. The goal is to see if it safely reduces heavy drinking and improves health.

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This Phase 3 trial tests an experimental drug called larsucosterol in 350 people with severe alcohol-associated hepatitis. The goal is to see if the drug helps patients survive for 90 days without needing a liver transplant. Participants receive either the drug or a placebo by IV…

This trial tests whether a six-week body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies, manage emotions better, and reduce alcohol cravings. Participants in inpatient treatment will either take part in mindfulness sessio…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. Participants use a joystick to push away alcohol-related images, aiming to retrain their automatic urges. The trial will enroll 176 veterans and measure cha…

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five da…

This study tests a new drug, GSK4532990, in about 393 adults with liver inflammation from alcohol use. The goal is to see if it safely reduces liver stiffness and improves liver function over 52 weeks. Participants receive either the drug or a placebo, and researchers monitor sid…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This trial tests whether a smartphone app called TRIS, paired with a Bluetooth breathalyzer and small daily cash rewards for verified abstinence, can help people with alcohol use disorder drink less. Participants submit three breath samples each day; those who are sober earn ince…

This trial investigates whether digital recovery support services—like smartphone apps and online tools—can help Black and African American adults in recovery from alcohol use disorder maintain their progress. Participants receive a menu of vetted digital resources plus a phone a…

This study tests whether giving people with moderate to severe alcohol use disorder a medication called naltrexone (as a pill or injection) right in the emergency department, along with a brief counseling session, helps them follow up with ongoing treatment. All participants rece…

This study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…

This early-stage trial is testing whether alirocumab, a drug approved for high cholesterol, is safe for heavy drinkers and might reduce liver inflammation. One hundred healthy adults who drink heavily will receive either alirocumab or a placebo injection over 8 weeks. Researchers…

This study tests a computer-based skills training program called Path180 for teenagers aged 13 to 19 with alcohol use disorder. Participants receive either standard treatment or standard treatment plus Path180, a 7-module program that teaches coping skills and motivation to cut b…

This study tests whether mindfulness-based relapse prevention, combined with wearable heart rate sensors, can help people with alcohol use disorder improve self-regulation and reduce drinking. About 120 adults will attend weekly group sessions for 8 weeks, answer mood and drinkin…

This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adul…

This study tests whether giving choline supplements to pregnant women who drink heavily can reduce the negative effects of alcohol on their baby's growth and brain development. Choline is an essential nutrient that supports cell membranes and brain function. The trial compares da…

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to a…

This study tests whether combining varenicline (a medication that helps people stop smoking) with financial rewards for clean urine samples can reduce alcohol and tobacco use in adults who both drink heavily and smoke daily. Participants are randomly assigned to receive either re…

This phase 3 trial investigates whether high-dose psilocybin, given alongside psychotherapy, can prevent relapse in people with severe alcohol use disorder who also have depressive symptoms. Participants receive either a high dose (25 mg) or a low dose (3 mg) of psilocybin in two…

This study tests whether a 30-day alcohol abstinence challenge, supported by a mobile app, is feasible and helps reduce heavy drinking. Researchers will enroll 150 adults in Oklahoma who drink regularly. Participants will try to completely avoid alcohol for one month, and the stu…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests whether a drug called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. Researchers will compare this combo to a placebo in 160 adults aged 18-80. The goal is to see if the treatment reduc…

This study looks at whether adding addiction counseling and monitoring after a liver transplant for alcohol-related liver disease can lower the chance of drinking again. About 720 adults who had a liver transplant for alcohol-related disease will be followed for two years. The go…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether full-spectrum or broad-spectrum CBD can help people with alcohol use disorder drink less. 180 adults who want to reduce or quit drinking will receive either CBD or a placebo for 12 weeks. Researchers will track changes in drinking habits, cravings, and an…

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests whether a combined computer- and counselor-delivered alcohol treatment program can help people who receive an early liver transplant for severe alcoholic hepatitis stay alcohol-free. Researchers will compare this program to standard care in 200 participants, trac…

This early-phase study tests whether suvorexant, a drug used for insomnia, can reduce people's motivation to drink alcohol. Thirty adults with moderate to severe Alcohol Use Disorder will receive suvorexant or a placebo, then choose between alcohol and money. Researchers will mea…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can safely slow or stop liver scarring (cirrhosis) compared to a placebo. About 256 adults with compensated cirrhosis will take the drug or placebo for 2 years. The main goal is to measure changes in liver stiffn…

This phase 3 trial tests whether adding N-acetylcysteine or extending prednisolone treatment beyond the standard 30 days can improve outcomes for people with severe alcoholic hepatitis. About 477 participants will be enrolled. The goal is to see if these strategies increase the n…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management classes, and relationship skills training to help couples reduce alcohol use. Researchers wi…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This study tests whether deep transcranial magnetic stimulation (TMS) can help Veterans with alcohol use disorder reduce relapse. About 100 participants will receive TMS targeting brain circuits linked to craving and emotional processing. The goal is to increase alcohol-free days…

This study tests whether guanfacine extended release (Intuniv), a drug currently used for ADHD and high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take either guanfacine or a placebo daily for 12 weeks, and report the…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This study tests a new behavioral therapy called CM-PST, designed to help young adults (ages 18-24) with alcohol use disorder achieve and maintain abstinence. The therapy combines rewards for abstinence with skills to manage daily challenges. The trial first checks if the therapy…

This study tests whether a virtual reality experience can help people in early recovery from alcohol use disorder drink less and stay abstinent longer. About 500 participants who have been sober for at least two weeks but less than a year will use a VR program designed to strengt…

This study tests a smartphone app called Smart-T Alcohol that sends personalized messages to help homeless adults reduce their drinking. About 600 people from shelters in Dallas and Oklahoma City will either get the app plus usual care, or usual care alone. The goal is to see if …

This study is testing whether apremilast (Otezla), a drug currently used for psoriasis and arthritis, can reduce alcohol cravings in people with moderate to severe alcohol use disorder. Researchers will compare two different doses of the drug against a placebo in 100 adults who w…

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and br…

This study tests whether short behavioral therapy sessions can improve sleep and reduce alcohol and cannabis use in young adults aged 18-29 who struggle with insomnia and heavy drinking or marijuana use. Researchers will enroll 800 participants in Washington State and compare tho…

This early-stage trial tests a new drug called NTX-2001 in 50 adults with alcohol use disorder. Participants take the drug or a placebo daily for two weeks. Researchers will measure how much alcohol they drink and check for side effects. The goal is to see if this drug can safely…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study is testing a new drug called CMND-100 (MEAI) in healthy volunteers and people with alcohol use disorder. The goal is to find a safe dose and see if it can reduce drinking and cravings. The trial is currently recruiting 84 participants.

This study tests whether a supplement called SAMe can improve liver function and reduce deaths in people with alcoholic cirrhosis. About 196 adults with mild to moderate cirrhosis will take SAMe or a placebo daily for 24 months. Researchers will measure liver health, gut function…

This pilot study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if this approach is feasibl…

This study tests whether deep brain stimulation (DBS) can safely reduce drinking in people with severe alcohol use disorder who haven't improved with standard treatments. DBS uses implanted electrodes to send small electrical signals to brain areas linked to craving and self-cont…

This study tests whether gentle brain stimulation (tVNS or CLAM-tACS) during mindfulness exercises can help people recovering from alcohol dependence stay sober. 140 detoxified patients will take part in a mindfulness-based relapse prevention program, with some receiving stimulat…

This Phase 2 trial tests whether probenecid, a drug currently used for gout, can reduce alcohol cravings and drinking in people with alcohol use disorder. Over 16 weeks, 120 participants will receive either probenecid or a placebo, and researchers will measure changes in craving …

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This Phase 2 trial tests whether guanfacine, a drug used for high blood pressure and ADHD, can help people with alcohol use disorder drink less. Researchers will compare guanfacine to a placebo in 160 men and women, measuring alcohol consumption in lab sessions and during a treat…

This Phase 3 trial tests a drug called LAENNEC, made from human placenta, in people with chronic liver disease. It compares giving the drug as an intravenous drip versus a standard shot under the skin. The main goal is to see if the IV form lowers liver enzyme levels more effecti…

This study tests whether taking capsules of processed donor stool (fecal transplant) can help people with liver cirrhosis avoid serious infections and hospital stays. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo an…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study tests whether a single dose of a ketone ester drink can reduce alcohol cravings and consumption in people with alcohol use disorder. Twenty non-treatment-seeking participants will receive either the ketone drink or a placebo on two separate days, then undergo brain sca…

This study tests a new telehealth program called B-FIT, which adds a family member or friend to standard therapy for veterans with alcohol use disorder. The goal is to see if involving a loved one helps veterans drink less and improve family relationships. About 400 veterans and …

This study is testing a treatment called IR-TMS, which uses magnetic pulses to target specific brain areas, to see if it can help people with Alcohol Use Disorder drink less. About 150 adults who drink heavily will receive several sessions of this treatment, along with brain scan…

This Phase 2 trial tests whether the hormone pregnenolone can help people with alcohol use disorder drink less heavily. 150 adults aged 18-70 will take either 300 mg of pregnenolone or a placebo daily for 12 weeks. The main goal is to see if more people in the pregnenolone group …

This Phase 2 trial tests whether adding cannabidiol (CBD) to standard naltrexone treatment can reduce alcohol cravings in people with alcohol addiction. 150 participants will receive either a high or low dose of CBD plus naltrexone, or a placebo plus naltrexone, for 14 days. The …

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether a monthly injection of naltrexone (a medication that blocks alcohol's rewarding effects) helps people who drink for pleasure reduce heavy drinking more than a placebo. About 60 adults with alcohol use disorder who drink heavily will receive either the sho…

This study is testing a smartphone app called MiREA-AC designed to help college students who have been mandated to reduce their alcohol and cannabis use. The app provides personalized feedback on their consumption and social norms. Researchers will enroll 150 students to see if t…

This study tests a computer-based training program designed to change the automatic urge to approach alcohol in people being treated for alcohol use disorder. 112 participants will be randomly assigned to one of three versions of the training, including a sham version. The goal i…

This study tests whether adding N-acetylcysteine (NAC) to standard steroid treatment helps people with severe alcoholic hepatitis live longer and have fewer complications. About 390 adults aged 18-75 with a high Maddrey score will be enrolled. The main goal is to see if the combi…

This pilot study tests whether chat-based text messaging and an online education hub can reduce alcohol consumption and binge drinking in Hong Kong adolescents aged 12-18 who have drunk alcohol in the past year. One hundred participants will receive the digital intervention, whic…

This study tests whether adding a caregiver session to a brief alcohol counseling program helps teens aged 12-17 reduce their drinking. 615 teens with mild alcohol problems will be assigned to teen-only counseling, counseling with a live caregiver session, or counseling with an o…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study tests whether suvorexant, a sleep medication, can help people with alcohol use disorder drink less and handle stress better. About 250 adults who want to cut back on alcohol will take either the drug or a placebo nightly for 8 weeks. Researchers will track drinking hab…

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests whether a single dose of ketamine, combined with real-time brain training (neurofeedback), can help people with alcohol use disorder drink less. 75 participants will receive either ketamine or placebo, plus real or fake neurofeedback. The goal is to see if the co…

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either ps…

This study tests whether an HMB-enriched amino acid supplement can reverse muscle loss and improve recovery in 48 patients with alcoholic liver disease and COVID-19 pneumonia. Participants receive either the HMB supplement or a balanced amino acid mix for 90 days. Researchers wil…

This study tests whether offering specialized alcohol use disorder treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 participants will either get this offer plus standard care, or standard care alone. The …

This early-phase trial at the Cleveland Clinic is testing whether a form of hyaluronic acid (HA35) can help prevent muscle loss in people with alcoholic hepatitis. 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visit…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans will either get medication alone or medication plus the app. The goal is to see if the app makes treatment more effective and ea…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder reduce heavy drinking and improve liver health. Researchers will compare the probiotic to a placebo in 60 adults who drink heavily. The goal …

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This study combines a mild brain stimulation technique called tDCS with computer-based cognitive training to see if it helps people with alcohol use disorder stay abstinent. Forty people who are already in a treatment program will receive 10 sessions over several weeks. Researche…

This study tests whether combining fMRI neurofeedback (brain activity training) and TMS (magnetic brain stimulation) can help people with alcohol use disorder drink less and feel fewer cravings. About 90 adults aged 19-65 who are already in treatment will attend weekly sessions f…

This study tests whether a modified ketogenic diet (very low in carbs) can help people with alcohol use disorder reduce their drinking. Fifty adults with the condition will follow the diet and receive nutritional counseling. Researchers will measure how well participants stick to…

This study tests a brain stimulation technique called theta burst stimulation (TMS) to see if it can reduce alcohol cravings and prevent relapse in people with alcohol dependence. Seventy-two adults who want to cut back or quit drinking will receive either real or sham stimulatio…

This early-stage trial tests a new long-acting naltrexone injection (IVL3004) against the approved drug Vivitrol in 40 healthy men. The goal is to compare how the drug moves through the body and check for safety. It does not yet test if it helps treat opioid or alcohol dependence…

This study is testing whether a mobile app called Pink Cloud can help people recovering from drug or alcohol problems stay sober. Over 1,400 adults who have completed treatment will use the app for a year, which includes a meeting finder, sobriety tracker, and planning tools. Res…

This study compares an electronic brief intervention delivered via an app to a traditional face-to-face brief intervention for people with unhealthy alcohol use. Researchers will enroll 1,200 adults in Mexico and South Africa who score 8 or higher on an alcohol screening test. Pa…

This early-stage trial tests whether a single dose of insulin given as a nasal spray can reduce alcohol cravings and consumption in people with alcohol use disorder. Forty non-treatment-seeking volunteers will receive either insulin or a placebo and then be exposed to alcohol-rel…

Researchers are studying whether a blood test called HepQuant DuO can measure liver function over time in people with alcohol-related liver disease. Participants drink a natural compound called cholate, then give two blood samples at 20 and 60 minutes. The study follows about 40 …

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study is testing whether combining new blood tests and stool analysis can detect liver fibrosis earlier than current methods. Researchers will follow 1200 adults referred to a community liver clinic. The goal is to identify advanced liver disease sooner and reduce unnecessar…

This study tests a program called PAL that gives hospital patients personalized feedback on smoking, drinking, diet, and exercise. About 788 patients will be split into two groups: one gets the feedback and support, the other gets usual care. The goal is to see if this low-cost a…

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot trial tests a counseling program called CHOICES-PLEAS for women in a jail-based substance use treatment program. The goal is to reduce the risk of substance-exposed pregnancies by helping women change their substance use and risky sexual behaviors. Participants receive…

This study tests whether a game called Singularities can help teens aged 14-18 reduce alcohol-related harms, like hangovers or risky behavior. About 2,000 participants will play either Singularities or a nutrition game and complete surveys over one year. The goal is to see if the…

This study tests different combinations of an online program called CARRII, designed to help Native American women reduce their risk of alcohol-exposed pregnancy. Over 500 participants will be randomly assigned to one of eight versions of the program for three months. The goal is…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether a program called Bright Horizons can help prevent binge drinking and drug use in Native American youth aged 10 to 24. The program teaches skills like managing emotions, coping with stress, and setting goals. Researchers will compare it to standard case ma…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a prevention program for binge drinking in 240 students aged 18-30. The program combines motivational interviewing with social psychology techniques to change drinking habits. Researchers will measure changes in binge drinking scores and readiness to change. The …

This study tests whether a brief, two-session alcohol counseling program can help Veterans reduce their drinking and prevent intimate partner violence. Researchers will compare this program to alcohol education or standard check-in calls. 300 Veterans who are already in a partner…

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

Researchers are testing whether a 12-week home cycling program can help adults with alcohol use disorder and alcohol-related liver disease drink less and crave alcohol less. Thirty participants join either the exercise program plus standard care or standard care alone. The study …

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

Researchers at the University of Missouri-Columbia are studying whether improving insomnia can lead to better alcohol outcomes in heavy-drinking adults. The trial enrolls 256 adults who meet criteria for alcohol use disorder and insomnia disorder. Participants receive five weekly…

This study tests whether low-intensity focused ultrasound (LIFU) can safely calm overactive brain areas linked to alcohol cravings. Twenty-five adults with alcohol use disorder will receive LIFU while researchers monitor side effects and measure brain activity changes with fMRI. …

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This early-stage study tests whether mavoglurant, a drug taken as a pill, can reduce alcohol cravings and drinking in people who drink heavily. Researchers will give the drug or a placebo to 63 adults with Alcohol Use Disorder and measure how much they drink and crave alcohol. Th…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study tests whether a smartphone-based program is practical and helpful for young adults aged 18-25 who have ADHD and drink heavily. Participants use the app for 31 days to improve awareness and self-control around alcohol. The goal is to see if the app reduces binge drinkin…

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This study tests whether a device that gently stimulates the forehead during sleep can help children aged 8 to 12 who have ADHD linked to prenatal alcohol exposure. The device, already cleared for general pediatric ADHD, is used at home by parents each night for four weeks. Resea…

This pilot study tests whether tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive weekly injections of either the drug or a placebo for 4 weeks. The goal is to see if the drug lowers cue-trig…

This study tests whether adding alcohol-related smells to virtual reality (VR) scenes is feasible and tolerable for people with alcohol dependence. Twenty participants will experience VR cue exposure with scents like beer or wine, and researchers will measure craving, side effect…

This study is testing a smartphone-based system called STAR that uses machine learning to predict when someone with alcohol use disorder might relapse. Participants will complete surveys and use the system to receive personalized recovery support messages. The goal is to see if t…

This study tests a wearable earpiece that gently stimulates nerves to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device or a sham version for 5 days during detox. Researchers will measure withdrawal severity, cravings, and …

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests a program that combines a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults who drink heavily. Researchers want to see if these tools are easy to use and helpful for drinking more moderately. The study inv…

This study tests a 9-week mindfulness program (MBRP-SA) designed to help cancer survivors quit smoking and reduce heavy drinking. Six hundred participants in Florida will either get the mindfulness program plus nicotine patches or standard quitline support. The goal is to see if …

This study tests a program called Thrive that helps young adults (ages 18-25) with fetal alcohol spectrum disorders (FASD) set personal goals and build support networks. Participants are randomly assigned to start the program right away or after a delay, and then to work individu…

This study looks at whether teaching college students protective strategies (like pacing drinks or avoiding shots) and setting personal goals can reduce risky drinking. About 300 students aged 18-25 who drink at least once a week will be split into three groups: one gets basic ad…

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This pilot study will test whether short, immersive virtual reality nature sessions can reduce depression, anxiety, and stress in adults with alcohol use disorder who are in an intensive outpatient program. Fifty participants will either receive standard care or add up to 12 VR n…

This study tests whether a non-invasive device that gently stimulates the vagus nerve can reduce withdrawal symptoms, anxiety, and cravings in 80 veterans with moderate-to-severe alcohol use disorder. Participants will receive the stimulation and complete questionnaires and a bra…

This study tests whether a chatbot powered by large language models can help people with metabolic alcohol-related liver disease (MetALD) reduce their alcohol intake. About 50 adults in Hong Kong will use the chatbot for counseling. The main goal is to see if the approach is prac…

This study is testing whether 12 weeks of group cognitive behavioral therapy (CBT) can help people reduce their alcohol or cannabis use. Researchers will enroll 400 adults with alcohol use disorder or cannabis use disorder. Participants will attend weekly CBT sessions, and the st…

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 adults who have both alcohol use disorder and treatment-resistant depression. Participants will receive weekly ketamine infusions and ACT sessions for 8 weeks. The…

This pilot study tests a therapy called Deaf-MET, which is a version of motivational enhancement therapy designed specifically for Deaf adults who use American Sign Language. The goal is to see if the therapy is practical, acceptable, and helps participants become more ready to c…

This study tests whether an 8-week mindfulness program can help Hispanic young adults (ages 18-25) who binge drink reduce their alcohol use. Participants are randomly assigned to either the mindfulness group or a control group that only fills out surveys. The program teaches stre…

This study tests whether brief training in mindfulness or cognitive-behavioral techniques can reduce heavy drinking in young adults aged 18-26. Participants will complete 1-4 training sessions and report their drinking via smartphone. The goal is to see if these techniques help p…

This study tests whether the My Health Coach app can improve quality of life and daily functioning for adults with fetal alcohol spectrum disorders (FASD). Two hundred participants will be split into two groups: one gets the app right away, the other waits 12 weeks. Everyone comp…

This study tests whether a supervised exercise program can improve sleep in people with alcohol use disorder. Forty adults with sleep problems will take part in activities like walking, cycling, and yoga. Researchers will track sleep quality, melatonin levels, and how well partic…

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based thinking exercises can improve attention, memory, and problem-solving in children aged 8 to 17 who were exposed to alcohol before birth. About 70 kids will be randomly assigned to re…

This study tests whether a type of brain stimulation called cTBS can reduce cravings for alcohol in people with alcohol addiction. 34 adults will receive 15 stimulation sessions over 5 days, and researchers will measure changes in their cravings, heart rate, and brain activity. T…

This study is creating and testing a short, online therapy program for LGBTQ+ people who have experienced trauma and drink alcohol. In the first phase, participants share their thoughts to make the program more helpful and welcoming. In the second phase, some participants can try…

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder. Participants will receive either the ketone drink or a placebo for 4 days during inpatient detox. The main goal is to see if the ke…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

Researchers are using PET scans to measure mitochondrial Complex-I and glucose metabolism in the brains of people with alcohol use disorder and healthy volunteers. The study aims to see whether these markers differ between the two groups and whether they relate to alcohol craving…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

Researchers are testing whether PT150, an experimental drug that blocks the body's stress hormone receptor, can reduce the physical and behavioral effects of stress and alcohol in people with alcohol use disorder. The study enrolls 34 adults who are not seeking treatment. Partici…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

Researchers at the University of Rochester are testing a program called FMF Connect Pro that trains mental health providers to screen for prenatal alcohol exposure, diagnose fetal alcohol spectrum disorders, and support caregivers through a companion app. The study compares two t…

Researchers at Yale University are using PET brain scans to measure two types of opioid receptors, mu and kappa, in people with alcohol use disorder and in healthy volunteers. Participants with alcohol use disorder complete detoxification and then undergo scans within the first d…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study looks at whether a blood marker called phosphatidylethanol (PEth), which reflects alcohol use over the past few weeks, can predict complications after surgery. Researchers will test PEth levels in 170 adults having elective surgery at University Hospitals Cleveland Med…

Researchers at Yale University are using PET brain imaging with a radiotracer called Bavarostat to measure levels of an epigenetic marker, HDAC6, in people with PTSD, alcohol use disorder, or both. The study includes 150 adults aged 18 to 70 and compares them with control groups.…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will test a new questionnaire about oral care and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers…

This trial investigates whether simply seeing, smelling, and holding a beverage—without drinking—changes craving in adults with alcohol use disorder. Participants will complete two sessions where they are exposed to water and a visually matched test beverage while rating their cr…

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study looks at how alcohol changes a brain protein called PDE4B, which may be linked to alcohol use disorder. Healthy social drinkers aged 21 to 70 will have brain scans before and after receiving alcohol. The goal is to understand how alcohol affects this protein, which cou…

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can change how the brain responds to alcohol-related cues in people with alcohol use disorder (AUD). Researchers will use brain scans to measure dopamine activity in healthy volunteers and people w…

This study looks at whether a short screening and brief counseling session can help reduce unhealthy alcohol use among adults visiting public hospitals in a post-war area. About 262 outpatients who drink at risky levels will either receive advice and follow-up or just follow-up a…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study works with Black teens on probation and their families to adapt alcohol and drug treatment to better address experiences of racial discrimination. Researchers will interview teens and hold focus groups with parents and community advocates to learn what works. The goal …

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study looks at whether a blood test for a marker of heavy drinking (carbohydrate-deficient transferrin, or CDT) can help predict how well critically ill patients will do in the intensive care unit. Researchers will follow 800 adults admitted to the ICU through the emergency …

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study tracks 1,500 people over two years to see how the COVID-19 pandemic has changed their drinking habits and related stress. Participants complete surveys about alcohol use, stress, and well-being, comparing before and during the pandemic. The goal is to understand the pa…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study is developing and testing a program called THRiVE for veterans who recently left the military. The program consists of six weekly virtual group sessions led by a peer (another veteran). The goal is to see if the program is practical, well-liked, and may help improve me…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study uses brain scans to see how stress-related proteins change in heavy drinkers compared to healthy people. Researchers give a stress hormone (hydrocortisone) and then scan the brain to measure these proteins. The goal is to understand if these proteins play a role in rel…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study looks at why alcohol use disorder is increasing faster in women than men. Researchers will measure brain activity, hormone levels, and drinking behavior in 100 adults to find sex-specific risk factors. The goal is to create better prevention and treatment strategies ta…

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study follows 7,500 heavy drinkers over time to learn how alcoholic liver disease develops and worsens. Researchers will use non-invasive tests like ultrasound and blood markers to identify who is at risk for cirrhosis and liver cancer. The goal is to improve screening and e…

This study looks at how impulsivity and the way people feel when drinking alcohol are connected in young adults aged 21-25. Researchers will give alcohol or a placebo intravenously and track participants' responses in the lab and in daily life using a phone app. The goal is to fi…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This study aims to see how Jägerbombs (a mix of energy drink and alcohol) affect young adults differently than drinking alcohol alone during a binge-drinking session. Researchers will measure reaction time, coordination, vision, stress hormones, and hangover symptoms in 24 health…

This early-stage study is testing a new implantable pellet (BICX104) that slowly releases naltrexone over 3 months. Researchers want to see how the body processes the drug and if it's safe, comparing it to a standard monthly naltrexone shot. The study involves 30 healthy adults a…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and reward in people with alcohol use disorder (AUD). Researchers will compare brain activity in people with AUD and healthy volunteers using MRI scans and a mild electrical stimulation techn…

This study tests a new program designed to help liver doctors provide treatment for alcohol use disorder. The program includes education for doctors and patients, decision support tools, and feedback on performance. Researchers want to see if this approach is practical and accept…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study aims to understand the different reasons people with alcohol use disorder are motivated to drink. Researchers will give participants IV alcohol and ask them to press a button for more doses, while measuring mood, cravings, and thinking skills. The goal is to link these…

This study explores why ketamine, a fast-acting antidepressant, works better in people with a family history of alcohol use disorder. Researchers will give a single low-dose ketamine infusion to 60 adults with treatment-resistant depression while scanning their brains with powerf…

This study tests a web-based program for romantic partners who are worried about their loved one's drinking. Researchers will use daily surveys from both partners to build personalized feedback that helps the concerned partner communicate better and motivate change. The goal is t…

This study looks at 350 hospitalized patients with alcohol use disorder to find out what makes someone more likely to relapse after detox. Researchers will group patients by shared traits and test a feedback system that shows test results to patients and doctors. The goal is to l…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This study looks at how drinking problems and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to better understand these connections, not t…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study looks at how anxiety affects the brain in people with alcohol use disorder during early and long-term abstinence. Researchers will use fMRI scans and the medication disulfiram (Antabuse) to help participants stay sober. They aim to understand the brain circuits linked …

This study looks at bacteria found in the liver, blood, and stool of 50 people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this se…

This study looks at whether a substance called PlGF in the umbilical cord and placenta can act as an early warning sign for brain damage in babies whose mothers drank alcohol during pregnancy. Researchers will compare PlGF levels between 60 pairs of mothers and babies—some with a…

This study aims to see if giving patients with alcohol-related liver disease customized alcohol treatment choices increases their participation in therapy or support groups. Researchers will enroll 268 adults from University of Michigan clinics and hospitals. The main goal is to …

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will give participants alcohol or a placebo and use brain scans to track changes over two years. The goal is to find early warning signs that could lead t…

This study looks at how alcohol causes muscle breakdown in people with alcoholic liver disease. Researchers will take a small muscle sample from the thigh to measure specific proteins linked to alcohol damage. The goal is to better understand the process, not to test a treatment.…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study looks at how two different proteins—whey and egg white—affect blood ammonia levels in people with advanced liver disease caused by alcohol. High ammonia can harm brain function. Fifty patients will try both proteins on separate days, and their blood and thinking skills…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study is testing a 10-week group parenting program called EQUIPE for parents with alcohol use disorder who have children aged 4 to 12. The goal is to see if the program reduces parental stress and improves parent-child relationships. Researchers will enroll 90 parents and me…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both co…

Acute alcoholic hepatitis is a serious liver condition with a high risk of death, but current prediction tools are limited. This study will analyze data from 1,400 patients to find more accurate markers of prognosis. By integrating clinical, lab, and tissue information, researche…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver disease, and healthy non-drinkers. The goal is to create a biorepository that researchers can use to study biomarkers and improve understanding of the disease. P…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study compares immune cell function in 30 healthy volunteers, heavy drinkers, and people with alcoholic hepatitis. Researchers will analyze blood samples to measure how mitochondria (the cell's powerhouses) work and how cells respond to inflammation. The goal is to better un…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study is testing a program called Get Better Together, designed to help military couples work as a team through life's challenges. About 1,000 couples will be randomly assigned to attend a weekend retreat or continue as usual. Researchers will track changes in mental health,…

This early-phase study at Yale University is investigating how the drug mavoglurant affects brain activity in people with a family history of alcoholism. Researchers will give 80 participants a single dose of mavoglurant or a placebo and use MRI scans to measure brain responses t…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study looks at medical records from 15,000 people to see how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are linked to other health problems. Researchers will track new cases of liver cancer and complications over time. The goal is to better understan…

This study looks at how well people with alcohol-related liver cirrhosis understand health information and how confident they feel managing their condition. Researchers will survey 200 participants to measure these factors and track liver complications over time. The goal is to l…