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Study aims to uncover why some young adults are prone to alcohol problems

NCT ID NCT05929677

Knowledge-focused Sponsor: Jessica Weafer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how impulsivity and the way people feel when drinking alcohol are connected in young adults aged 21-25. Researchers will give alcohol or a placebo intravenously and track participants' responses in the lab and in daily life using a phone app. The goal is to find new targets for preventing or treating alcohol use disorder.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alcohol and placebo (saline) given intravenously
What this could lead to
If successful, this could point toward new ways to prevent or treat alcohol use disorder by targeting impulsivity and how people respond to alcohol.
What could go wrong
This is an early-phase observational study, not a treatment trial. It may not lead to any direct benefit for participants or translate into real-world interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 21-25 years old * Report drinking to an estimated BAC \> .08% at least once in the past 30 days based on responses on the Timeline Followback (TLFB) * Report drinking at least twice weekly in the past 30 days based on responses on the TLFB * Fluency in English Exclusion Criteria: * Any serious medical problems (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders) * Body weight \< 110 or \> 210 pounds * Axis I psychiatric disorders including substance use disorder other than mild or moderate alcohol or mild cannabis use disorder * Current alcohol withdrawal or history of medically-assisted detoxification * Two positive breath alcohol concentration (BrAC) readings (i.e., \> 0.00%) at an in-person screening appointment or experimental session * Positive urine screen for illegal drugs other than cannabis * Currently seeking or past-12-month history of inpatient or intensive treatment for addictive behaviors * Current psychotropic medication use or receipt of a prescription for these medications in the past 30 days * Psychosis or other psychiatric disability * Pregnancy, nursing or lack of reliable birth control use for women * Report smoking \> 5 cigarettes per day (to avoid acute nicotine effects or withdrawal during experimental sessions)

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Conditions

The condition(s) this trial relates to.

alcohol abuse Behavior, Addictive Impulsive Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alcohol use disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Northeastern University

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Ohio State University

    RECRUITING

    Columbus, Ohio, 43221, United States

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