Scientists collect samples to unlock secrets of alcoholic liver disease

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Alcoholic Steatosis Patients Inclusion * Fat accumulation (Steatosis) without signs of fibrosis/ inflammation in patients with alcohol abuse (alcohol intake \>60 g/day in men and \>40 g/day in women) * Abnormal liver serum tests indicative of liver disease (elevated AST\>ALT, y-glutamyl transpeptidase and bilirubin) . Alcoholic Hepatitis with Mild Fibrosis Inclusion * Steatosis plus hepatocellular damage (presence of Mallory bodies and hepatocellular ballooning) * Polymorphonuclear infiltrate * Fibrosis stage 1-2 Alcoholic Hepatitis with Advanced Fibrosis Inclusion * Steatosis plus hepatocellular damage (presence of Mallory bodies and hepatocellular ballooning) * Polymorphonuclear infiltrate * Fibrosis stage 3-4. Alcoholic Cirrhosis Inclusion * Fibrosis stage 4 * Presence of complications of cirrhosis such as esophageal varices with our without a previous episode of bleeding, splenomegaly, ascites, hepatic corroborate the diagnosis of cirrhosis. Alcoholic Cirrhosis with HCC Inclusion -Diagnostic criteria of cirrhosis and established HCC. The diagnosis of HCC will be established based on histological confirmation or contrast-enhanced radiographic imaging according to the AASLD recommendations. Exclusion * BMI\>35 * HBV * Hemochromatosis * Wilson's disease * Autoimmune hepatitis * Drug-inducted liver disease * Hepatitis C * Antitrypsin deficiency * Patients who do not sign informed consent. Non-alcoholic steatohepatitis Inclusion -Biopsy proven NASH and chronic liver disease due to HCV patients. Exclusion * Cancer * Diabetes * Hypertension * CAD or stroke * Past history of liver disease * Hepatitis C * Antitrypsin deficiency * Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men * BMI \>35. Healthy controls Inclusion -AUDIT-C score less than 4 in men and less than 3 in women. Exclusion * Cancer (except of non-melanoma skin cancer) * Diabetes * Hypertension * Hypercholesterolemia * Coronary artery disease or stroke * History of current or past liver disease of any etiology * BMI \>27Kg/m2