The Cleveland Clinic

This study looks at whether a supplement called HMB (a natural substance related to the amino acid leucine) can help reverse muscle loss in people who have both alcoholic liver disease and COVID-19 pneumonia. About 48 participants will take the supplement and be monitored for cha…

This study is testing whether a leucine-enriched amino acid mixture can help reverse muscle loss in people with liver cirrhosis. About 32 participants will take either the special mixture or a control mixture for 3 months. Researchers will measure changes in muscle protein produc…

This study tests whether combining non-invasive brain stimulation (rTMS) with a special electrical stimulation therapy (CCFES) can improve arm and hand function in people who had a severe stroke at least 6 months ago. The therapy aims to excite the undamaged side of the brain to …

This study is testing a new clinic designed to find and treat muscle loss (sarcopenia) in people with COPD. About 80 adults who have been hospitalized for COPD will join. The clinic uses CT scans to check muscle mass and offers a team approach with a lung doctor, pharmacist, and …

This study tests whether a mix of hot and cold techniques to remove large colon polyps (20 mm or larger) lowers the chance of polyps coming back, without raising the risk of complications like bleeding or a hole in the colon. About 194 adults will be randomly assigned to one of t…

This study tests whether a two-step treatment—first a procedure to lower liver pressure (TIPS), then weight-loss surgery (sleeve gastrectomy)—improves quality of life and weight loss more than standard medical care alone. It includes 70 adults with cirrhosis, severe obesity, and …

This study tests whether using antiseptic-coated sutures during Whipple surgery (pancreatoduodenectomy) can lower the chance of a pancreatic fistula—a serious leak of digestive fluids. About 436 adults scheduled for this surgery will be randomly assigned to receive either the coa…

This study compares two common surgical techniques for removing kidney stones: one using a vacuum-assisted sheath and the other using a standard sheath. About 90 adults with kidney stones between 10-25 mm will take part. The goal is to see which method clears more stones and caus…

This study tests whether a special mix of amino acids (HMB-enriched) can reverse muscle loss in people with cirrhosis. About 24 participants will take either the active supplement or a placebo for 3 months. The goal is to see if the supplement helps build muscle and improve healt…

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by severe liver disease. About 40 adults with cirrhosis who have been hospi…

This study tests whether eating Medjool dates from 34 weeks of pregnancy can help labor start on its own, reducing the need for medical induction. Researchers will track 250 pregnant women at Cleveland Clinic to see if date consumption affects labor length, medication use, and bl…

This study tests whether adding a small preventive procedure (foraminotomy) during neck decompression surgery can lower the chance of developing C5 palsy, a rare complication that causes arm weakness and pain. About 480 adults with cervical myelopathy (spinal cord compression) wi…

This study tests whether tirzepatide, a weight-loss medication, can reduce the burden of atrial fibrillation (an irregular heart rhythm) in 100 adults with obesity. Participants will receive either tirzepatide or a placebo for 12 months. The goal is to see if significant weight l…

This study follows 200 people who receive the Triathlon Hinge Knee system, either as a first knee replacement or to fix a previous one. Researchers will check how well the knee works and how long it lasts over 1, 2, 6, and 10 years. The goal is to see if the implant stays in plac…

This study looks at 300 adults with septic shock in the ICU. It uses a computer tool to randomly assign patients to get vasopressin either early or later, based on their norepinephrine dose. The goal is to see if the timing affects how much norepinephrine they need and if the too…

This study tests whether using a CPAP machine in a personalized way can lower the amount of time people with sleep apnea spend in atrial fibrillation (AFib). Twenty adults with both conditions will have their heart monitored via an implanted device. Each person will alternate per…

This study follows 40 people with multiple sclerosis (MS) for 48 months to see if two MRI brain scan markers—the central vein sign and paramagnetic rim lesions—can help doctors diagnose MS more accurately and track how the disease changes over time. Participants will have brain M…

This study tests if a common anti-inflammatory drug (diclofenac) can control pain after a needle procedure for chronic elbow pain as well as a narcotic (tramadol) does. About 92 adults will be randomly assigned to one of two groups and track how many pain pills they take over two…

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue in people with sarcoidosis. It also looks at effects on anxiety and depression. About 100 adults with sarcoidosis and fatigue will either join the MBSR program or a mon…

This study compares two ways to help the stomach empty properly after surgery to remove the esophagus (esophagectomy). One method uses Botox injections into the stomach valve, and the other is a surgical cut (pyloromyotomy). The goal is to see if Botox works as well as surgery at…

This study is testing whether giving methadone during and after major spine surgery can help patients use fewer opioids in the long run. About 120 adults having multi-level spine fusion will be randomly assigned to receive either methadone or a placebo. The main goal is to see if…

This study tests a laser treatment done in the doctor's office for men whose BPH (enlarged prostate) symptoms came back after a prior minimally invasive procedure. The goal is to see if this laser treatment can improve urine flow and sexual function without needing more invasive …

This study tests whether online group education and lifestyle support can improve quality of life and health in women with PCOS and obesity. Forty non-pregnant women aged 18-49 with PCOS and a BMI of 30 or higher will join virtual sessions or a control group. Researchers will mea…

This study tests a small steroid insert placed in the tear duct to control pain and swelling after vitreoretinal eye surgery. About 30 adults having surgery for a macular hole, epiretinal membrane, or vitreomacular traction will either get the insert or standard steroid eye drops…

This study looks at whether using a virtual reality headset (Apple Vision Pro) during endoscopy can reduce physical strain on doctors. About 140 procedures will be done with the headset, and researchers will measure posture and movement to see if it lowers the risk of injury. The…

This study compares two medicines, sugammadex and neostigmine, to see which one helps patients recover faster from muscle paralysis used during an ERCP procedure. About 80 adults will take part. The goal is to shorten recovery time and reduce side effects like nausea.

This study compares two types of shockwave therapy (focused and radial) to a fake treatment (sham) for men with erectile dysfunction or chronic pelvic pain, including those who had prostate cancer. About 186 men will be randomly assigned to receive one of the therapies or sham. T…

This study tests if using a small ultrasound probe placed inside the heart (called ICE) works as well as the standard throat ultrasound for guiding the placement of a Watchman device. The Watchman is a small plug that helps prevent strokes in people with atrial fibrillation. Abou…

This study tests a redesigned breathing device that lets doctors switch between two types of airway support without extra tools. The goal is to keep oxygen levels stable and reduce breathing complications during general anesthesia. About 100 adults having planned surgery will tak…

This study tests a cream called ruxolitinib for treating stubborn skin rashes in people with dermatomyositis, a rare autoimmune disease. Researchers want to see if the cream is safe and can reduce skin activity and severity over 8 to 12 weeks. The study involves 15 adults and is …

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming to the doctor's office. The lead is used to see if a permanent nerve device might help their symptoms. Researchers want to know if women are just as satis…

This study tests whether a one-time Botox injection into the side belly muscles, given 3-7 weeks before open hernia surgery, helps surgeons close the abdominal wall completely. About 188 adults with large ventral hernias will be randomly assigned to get Botox or a placebo shot. T…

This study tests a new way to numb pain during knee replacement surgery. Doctors will inject a long-lasting anesthetic directly into the back and inner side of the knee joint. About 60 adults having knee replacement will be randomly assigned to one of three pain-blocking methods.…

This study tests whether virtual group counseling (Shared Medical Appointments) helps patients feel more prepared and satisfied before pelvic organ prolapse surgery, compared to standard individual phone calls. About 106 adults scheduled for surgery at Cleveland Clinic will fill …

This study compares two ways to numb the belly area before open upper abdominal surgery. One method is newer and the other is standard. The goal is to see which one works better for pain control and is easier for doctors to learn. About 100 adults having surgery like stomach or l…

This study tests whether forced aerobic exercise (using a stationary bike that helps move your legs) can improve arm and leg recovery in people who had a stroke 3-9 months ago. Researchers will measure movement, brain activity, and blood markers of healing, and compare costs to s…

This study aims to better understand sarcopenia (muscle loss) in people with heart failure. Researchers will use special MRI scans to measure muscle properties in 70 participants—some with heart failure and sarcopenia, some without. No treatments or drugs are tested; the goal is …

This study looks at how a substance called HA35 affects muscle protein balance in healthy adults. Twenty-four participants will take either HA35 or a placebo for three days, then undergo medical tests, muscle biopsies, and a gut permeability test. The goal is to understand how HA…

This study aims to improve how doctors predict which patients with a weakened heart muscle and a leaky mitral valve will respond to treatments like medication or a valve repair device (MitraClip). Researchers will use advanced heart MRI scans to create personalized risk profiles.…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients and track their outcomes for one year. The goal…

This study looks at why people with cirrhosis (scarred liver) often lose muscle and fat, which can make them sicker. Researchers will compare tissue samples from 16 cirrhosis patients getting a liver transplant and 16 healthy people having other abdominal surgery. They will measu…

This study aims to find the best combination of tests to detect mild autonomous cortisol secretion (MACS) in people with adrenal incidentalomas—non-cancerous tumors found by chance on scans. Researchers will enroll 20 adults and compare several diagnostic tests, including blood, …

This study looks at how muscle protein is made and broken down in people with cirrhosis, a serious liver condition. Researchers will use special tracers and a single muscle biopsy to measure these processes. The goal is to better understand muscle loss in cirrhosis, which could l…

This study looks at how 12 weeks of either resistance or endurance exercise changes muscle mass in people with cirrhosis, a liver condition that often leads to muscle loss. Researchers will compare these two types of exercise to standard care in 40 adults. The goal is to understa…

This study is a worldwide registry that will follow 5,000 adults with breast cancer, blood cancers, or those on certain immune therapies. Its goal is to collect data on patients' health, treatments, and heart events to better understand and predict heart problems caused by cancer…

This study looks at whether people can safely do bowel stimulation at home for 3 weeks before surgery to close an ileostomy. The goal is to see if this simple daily routine can help the bowel wake up faster after surgery, reducing hospital stays and complications. About 34 adults…

This study looks at how GLP-1 and GIP agonists (medicines for diabetes and weight loss) affect bowel preparation quality in people getting a colonoscopy. Researchers will compare what happens when patients either skip or take their usual dose before the procedure. The goal is to …

This study aims to understand how alcohol affects immune cells and energy production in the body. Researchers will collect a blood sample from 30 participants—healthy controls, heavy drinkers, and people with alcoholic hepatitis—to compare their immune responses and cell function…

This study tests whether wrist-worn devices can safely monitor pregnant women with congenital heart disease at home. Researchers will track heart rhythms and other data from 50 participants to see if early warning signs of complications can be detected. The goal is to improve car…

This study looks at how well people with amblyopia (lazy eye) or strabismus (crossed eyes) see, even after treatment. Researchers will measure things like sharpness, contrast, and reading ability in 150 participants. The goal is to better understand what vision problems remain af…

This early-phase study looks at how a supplement called HA35 affects muscle mass in people with alcoholic hepatitis. Over 90 days, 54 participants will take either HA35 or a placebo and undergo tests like blood work, muscle biopsies, and body scans. The goal is to understand if H…

This study aims to understand how exercise affects the aorta in people with aortic aneurysm. Researchers will use special MRI scans during exercise to measure how the aorta stretches and responds. They will also test tissue samples from surgery to see how the aorta's physical pro…

This study collects blood and urine samples from 500 people, including those with alcoholic liver disease, heavy drinkers without liver damage, and healthy non-drinkers. The goal is to create a biorepository that researchers can use to find biomarkers and better understand the di…

This study looks at how social factors like income, insurance, and community distress affect the early diagnosis and treatment of heart failure. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in detection and medication …

This study looks at how alcohol causes muscle loss in people with alcoholic liver disease. Researchers will take a one-time muscle sample to measure specific protein changes. The goal is to understand the process, not to test a treatment. About 40 adults aged 18 to 65 with alcoho…

This study compares two standard surgical methods to remove the adrenal gland: laparoscopic (small tools with a camera) and robotic (surgeon controls a robot). The goal is to see which approach leads to better patient recovery and is more efficient for the surgeon. About 54 adult…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like LASIK or corneal crosslinking. Researchers will take detailed images of the eyes of 60 participants—some with kerato…

This study aims to improve how we detect and understand heart disease using a new type of MRI that looks at the heart's microscopic structure. Researchers will compare these advanced scans with standard tests and blood work in 1,000 adults, both healthy volunteers and those with …

This study aims to find better ways to measure kidney disease progression in people with Autosomal Recessive Polycystic Kidney Disease (ARPKD), a serious genetic condition. Researchers will use special MRI scans to track changes in kidney health over three years in 45 patients an…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see how well they measure heart valve problems and heart function. Researchers will enroll 200 adults with suspected moderate to severe valve disease. No treatment is given; the goal is…

This study collects blood and tissue samples from up to 2,000 adults with or without heart rhythm problems (arrhythmias) to find genetic links. Researchers will analyze DNA to understand why some people develop arrhythmias. No treatment or medication is given—this is a research-o…

This study looks at how changing the strength of deep brain stimulation affects sleep in people with Parkinson's disease. Ten participants will try three different stimulation levels over six weeks while their brain activity and sleep quality are recorded. The goal is to find whi…

This study tests whether a special eye scan (OCT) can measure inflammation inside the eye in people with uveitis. Researchers will scan 1,500 patients to see if the machine can grade inflammation as well as a doctor can. The goal is to make monitoring inflammation easier and more…

This study uses special MRI scans to see how the heart's structure and energy use change after bariatric surgery or cardiac rehab. Researchers will scan 150 adults before and 6-12 months after these treatments. The goal is to understand how these metabolic interventions affect he…

This study aims to learn more about uveitis, an eye condition that causes swelling, by looking at patients' DNA. Researchers will collect blood from 1,500 people with uveitis and sequence their genes to find mutations or patterns linked to the disease. No new treatments are being…

This study tests a new AI-powered chatbot called OPUS that helps pregnant patients understand and decide about prenatal genetic testing. Researchers want to see if using the chatbot helps patients feel more informed and less conflicted about their choices. The study will involve …

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study looks at whether changing what you eat can lower levels of a gut-made chemical called TMAO, which is linked to higher heart disease risk. Researchers will measure TMAO in the blood of 170 adults before and after a 12-week diet change. The goal is to see if diet alone c…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor. Researchers will use EEG and MEG to record brain activity with the stimulator on and off, and also test other tremor-reducing methods like cooling the limb or medication. …

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and cause inflammation and blood clots in diseases. Participants give blood at the Cleveland Clinic. No treatment or medication is given. The goal is to build a biorepository for f…