The Cleveland Clinic

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This study tests whether a clinical decision support tool, embedded in electronic medical records, helps doctors prescribe more effective blood pressure medications. About 168 adults with uncontrolled hypertension will be enrolled. The main goal is to see if the tool leads to low…

This study aims to see if a blood test for TTG-IgA antibodies combined with symptom information can accurately sort adults into low, intermediate, or high risk for celiac disease. Researchers will analyze data from 15,500 patients who already had both a blood test and a duodenal …

This trial compares two short, one-session therapies for teens aged 12-17 hospitalized for suicidal thoughts or attempts. One therapy (CAMS-BI) focuses on understanding and addressing the personal reasons behind suicidal feelings, while the other (Stanley-Brown Safety Planning) b…

This study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also rec…

This study is investigating how GLP-1 receptor agonist drugs, commonly used for type 2 diabetes, affect the movement of the entire digestive tract. Researchers will use a special swallowed capsule to measure gut motility in 20 adults before they start the medication and again aft…

This study investigates how brain signals relate to freezing of gait and balance problems in people with Parkinson's disease. Participants, who already have a deep brain stimulation (DBS) device, will walk in a virtual reality home-like environment while their brain activity is r…

This study uses advanced MRI and spectroscopy to track how semaglutide therapy changes muscle strength, volume, and quality over six months. Researchers will measure muscle function and fat infiltration in people with type 2 diabetes and obesity. The goal is to understand whether…

This study compares two robotic bronchoscopy systems—Ion shape-sensing and Galaxy electromagnetic—to see which one is better at getting tissue samples from lung nodules. About 346 adults scheduled for a routine bronchoscopy will be randomly assigned to one of the two robots. The …