The Cleveland Clinic

This early-phase study tested whether injecting donor stem cells directly into the colon could help people with severe Crohn's colitis that didn't respond to standard treatments. Only 7 people took part before the study was stopped early. The main goal was to check safety, but be…

This early-stage study tested whether injecting donor stem cells (remestemcel-L) into the colon could help people with severe ulcerative colitis that hadn't responded to other treatments. Only 7 adults took part before the trial was stopped early. The main goal was to check safet…

This study compared two surgical methods for removing diseased intestine in people with Crohn's disease: one that cuts the main artery high up, and one that spares the mesentery (the tissue holding the intestine). The goal was to see which technique better prevents the disease fr…

This study tested whether a team-based approach using continuous glucose monitors could help adults with type 1 diabetes better control their blood sugar and avoid another hospital stay after a diabetic ketoacidosis (DKA) episode. Only 2 people enrolled before the study was stopp…

This trial tests whether nortriptyline, an antidepressant, can reduce abdominal pain and improve quality of life in people with nonulcer dyspepsia—a condition causing stomach discomfort without an ulcer. Participants take either nortriptyline or a placebo capsule nightly for 8 we…

This study compared two types of drainage setons—Ethibond suture and vessel loop—for treating complex anal fistulas. The goal was to see which material drains infection better, lasts longer, and improves quality of life. However, the trial was terminated early after enrolling onl…

Researchers at the Cleveland Clinic are following 380 adults with hypertrophic cardiomyopathy, thoracic aortic dilatation, or radiation-induced heart disease. Participants complete a detailed survey at the start and again nine months later. The survey measures global, physical, e…

This observational study aimed to understand why some septic shock patients respond better to the drug vasopressin. Researchers planned to compare blood markers, heart ultrasound images, and tissue oxygen levels between responders and non-responders. However, the study was termin…

This study looked at whether weight-loss surgery can lengthen telomeres, which are caps on our DNA that shorten as we age. Researchers compared telomere length in people with severe obesity who had surgery versus those who did not. The goal was to see if rapid weight loss might r…

This study aimed to measure how abdominal wall tension and internal pressure change during hernia repair surgery in people with large hernias. Researchers used a special scale and a pressure-sensing urinary catheter during the operation. Only 2 people took part before the study w…