The Cleveland Clinic

This study tested new patterns of deep brain stimulation (DBS) for people with Parkinson's disease. Researchers wanted to see if delivering stimulation in short, timed bursts could control movement symptoms as well as the current standard of constant stimulation, but with less im…

This study tested a 24-week virtual program that combined prescription weight-loss medications (like Wegovy and Zepbound) with behavioral coaching from WeightWatchers. Researchers wanted to see if this combined approach helped people lose more weight than medication alone might. …

This study compared two different heart mapping systems (RHYTHMIA and CARTO) during repeat procedures for atrial fibrillation. Researchers wanted to see which system could better identify gaps in previous treatments and lead to better outcomes. The study involved 49 adults who ne…

This study compared two surgical techniques for removing kidney stones: the standard procedure (PCNL) and a newer 'mini' version with a smaller incision. The goal was to see if the smaller approach led to less blood loss and fewer complications. The trial involved 18 adults with …

This study tested if a special group clinic could help people with sleep apnea use their prescribed breathing machine more often. 56 adults who were struggling to use their machine regularly were assigned to either attend this group clinic or receive their usual care. The goal wa…

This study compared two brands of surgical mesh used to repair vaginal vault prolapse, a condition where the top of the vagina drops down. Over 100 patients were randomly assigned to receive one of the two mesh types during a minimally invasive surgery. Researchers followed patie…

This study tested whether using a wireless monitoring system that alerts nurses can help catch and reduce dangerous changes in breathing, heart rate, and oxygen levels in patients recovering from major surgery. It involved 227 adults who stayed in the hospital after non-heart sur…

This study tested if using a continuous glucose monitor (CGM) could help manage blood sugar in people with type 2 diabetes after they received a kidney transplant. Twenty patients wore the monitor for three months to see if better glucose control could reduce hospital readmission…

This study tested how well a wearable, sticker-like thermometer (TempTraq) measures body temperature compared to the standard method (a catheter placed near the heart) in intensive care unit (ICU) patients. Researchers enrolled 60 adults with the standard catheter already in plac…

This study tested a new imaging technique to help surgeons see bile ducts more clearly during gallbladder removal surgery. Researchers compared a special fluorescent dye and camera to standard surgical lighting in 677 patients. The goal was to see if the glowing dye made it easie…

This study tested how well the Dexcom G7 continuous glucose monitor works for patients recovering from heart surgery. Researchers compared the monitor's readings against standard blood glucose tests taken during the patients' hospital stay. The goal was to see if the wearable sen…

This study tested a new way to get cervical cancer screening results to women in El Salvador. Over 1,100 women were split into two groups: one received their results via text message, while the other followed the standard process of returning to a clinic. The goal was to see if t…

This study tested whether a wearable, continuous glucose monitor (a small sensor worn on the skin) is as accurate as standard blood tests for patients recovering from heart surgery. Researchers compared the sensor's readings to traditional finger-prick and blood draw results in 4…

This study tested whether using a simple blood test more widely could help find more people with a specific, treatable cause of high blood pressure called Primary Aldosteronism (PA). Researchers checked 53 adults with high blood pressure to see how many cases of PA were being mis…

This study tested whether a procedure called radiofrequency microneedling could improve melasma, a common skin condition causing dark patches. Ten adults with darker skin tones received three treatments over three months. Researchers measured changes in the severity of the dark p…

This study tested whether injecting numbing medication near specific chest muscles (nerve blocks) provides better pain relief than standard pain medications after minimally invasive heart valve surgery. Researchers enrolled 210 adults undergoing this specific procedure to compare…

This study tested whether a safe, non-invasive form of brain stimulation could boost the benefits of physical therapy for arm and hand movement. People with a cervical spinal cord injury received 15 sessions of arm training paired with gentle electrical brain stimulation over sev…

This small study explored whether acupuncture could help people with chronic heart failure feel better and function better. Researchers tested if adding acupuncture to standard medications could improve heart function, walking distance, and quality of life. The goal was to see if…

This study tested whether adding Reiki (an energy-based light touch therapy) and gentle manual massage to standard care could help patients recover better after heart surgery. Researchers enrolled 272 adults who had coronary artery bypass or valve surgery. One group received 20-m…

This study tested whether a fast-acting cooling spray could safely reduce the pain adults feel when getting an IV needle placed in the emergency room. Researchers compared the spray to a harmless water spray in 300 stable patients. The goal was to find a quick, needle-free way to…

This study compared two common pain medications—ketorolac (an NSAID like ibuprofen) and oxycodone (an opioid)—to see which worked better for pain after kidney stone surgery. Eighty-one patients who had a ureteroscopy procedure were randomly assigned to take one of the medications…

This study looked at whether a newer pain medication called oliceridine causes fewer breathing problems than standard opioids after major surgery. Researchers monitored 111 adults having major operations to see if their breathing was affected while using the medication. Patients …

This study tested how well different warming blankets and blower devices prevent heat loss in healthy volunteers. Researchers measured heat transfer at 15 body sites while participants used various warming systems. The goal was to gather data on which equipment works best to keep…

This study aimed to see if a person's weight and their answers to short sleep apnea questionnaires could help predict who might have breathing or sedation problems during common procedures like colonoscopy or upper endoscopy. Researchers followed 350 adults with a body mass index…

This study aimed to understand how a steroid implant placed in the eye affects detailed images of inflammation in people with uveitis. Researchers followed 30 patients for one year, taking special eye scans before and after they received the implant. The goal was to see if change…

This study used virtual reality to safely trigger freezing episodes in people with Parkinson's disease who have deep brain stimulators. While participants walked through VR environments, researchers recorded their brain signals to understand what happens in the brain during freez…

This study aimed to understand how exercise might help with thinking and memory problems in Parkinson's disease. Researchers measured brain activity in 25 people with Parkinson's while they did two types of stationary cycling. The goal was to find a specific brain pattern linked …

This study aimed to improve how doctors and pregnant patients discuss a new prenatal blood test called NIPT. Researchers tested a communication tool to help patients make more informed choices about whether to get the test. The study involved nearly 700 pregnant women, their part…

This study aimed to understand how increased pressure in the abdomen during laparoscopic weight-loss surgery affects pressure in the brain and the function of the kidneys. Researchers measured hormone levels, urine output, and brain pressure indicators in 16 patients undergoing s…

This study looked at whether people should temporarily stop taking certain diabetes and weight loss medications before an upper endoscopy. Researchers wanted to see if pausing these drugs reduces leftover food and liquid in the stomach, which can increase the risk of breathing pr…

This study aimed to understand if the body processes choline—a nutrient needed for health—differently when it comes from eggs versus from supplements. Researchers wanted to see if these different sources changed the level of a blood compound (TMAO) linked to heart disease risk. T…

This study aimed to understand how a serious inherited disease called hereditary transthyretin amyloidosis begins. Researchers followed 37 people who carry the disease gene but had no symptoms, tracking a specific protein in their blood over five years. The goal was to see if thi…

This study aimed to understand if tracking a blood marker called cystatin C could give doctors early warning that a patient's kidneys might be harmed by the fluid-removing (diuretic) drugs used to treat sudden heart failure. Researchers followed 64 hospitalized patients, taking d…

This study aimed to find a way to predict which premature infants with lung disease might have future breathing or brain development problems. Researchers measured levels of certain proteins, called neurotrophins, in the blood of 70 infants in the intensive care unit. The goal wa…

This study aimed to understand how pain in one knee affects the forces on the other knee and the rest of the body during walking. Researchers compared 30 adults with painful knee arthritis to 25 healthy adults by having them walk on a treadmill under different conditions. People …