The Cleveland Clinic

This study tests whether a point-of-care device (Quantra) that quickly measures blood clotting can guide doctors to give fewer blood transfusions during and after complex heart surgery. About 666 adults having high-risk heart procedures will be randomly assigned to either the dev…

This study looks at two different ways to use weight loss medications over 21 months in 150 adults with obesity. Participants first take a weekly injection (tirzepatide or semaglutide) for 9 months, then switch to a daily pill (either phentermine-topiramate/naltrexone-bupropion o…

This study looks at whether a steroid injection given right after knee surgery can help reduce pain and inflammation in people with osteoarthritis and meniscus tears. About 150 adults aged 40 and older will receive either the injection or a placebo. The goal is to see if the inje…

This study tests a new digital twin system that creates a virtual copy of each patient to guide personalized treatment for type 2 diabetes. 150 adults with diabetes will be randomly assigned to either the digital twin program or standard care for one year. The goal is to see if m…

This study looks at whether a healthy diet and exercise program can help people with pulmonary arterial hypertension (PAH), a serious lung condition. The idea is that improving how the body handles sugar (insulin sensitivity) might also improve blood flow in the lungs. About 34 a…

This pilot study tests whether keeping blood pressure higher during and after major surgery can lower the risk of serious heart, kidney, and brain problems. About 80 adults aged 45 and older who take blood pressure medication will be randomly assigned to either tight or routine b…

This study looks at whether a dietary supplement called ketone ester can improve heart function in people with heart failure. About 50 participants will receive either the supplement or a placebo for 12 weeks, and their hearts will be scanned with MRI before and after. The goal i…

This study aimed to see if stem cells from a donor could safely help heal fistulas in people with Crohn's disease who have an ileal pouch. It planned to enroll adults aged 18-75 with a pouch in place for at least 6 months. However, the study was withdrawn before any participants …

This pilot study tests whether a new rinsing device (Swiftsure SwishKit) plus standard mouth care can lower harmful bacteria in the mouths of ICU patients who are on breathing tubes. About 21 adults will be randomly assigned to either standard care alone or standard care plus the…

This study tests two approaches—rapid diagnostic testing and pharmacist-led de-escalation—to reduce the use of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Over 12,500 participants across multiple hospitals will be assigned to one of four g…

This study tests whether adding mild electrical stimulation to standard wound care helps heal stage 1 or 2 pressure ulcers (bedsores) on the lower back or tailbone. About 1,100 hospitalized adults will be randomly assigned to receive either standard care alone or standard care pl…

This study aimed to test if stem cells from donated bone marrow are safe and workable for people with severe pouchitis, a complication after colon surgery for inflammatory bowel disease. It was designed for adults aged 18-75 who had not responded to standard treatments. The study…

This study tests whether a uterus transplant from a deceased donor can help women with uterine factor infertility—due to missing, damaged, or surgically removed uterus—give birth. Ten participants will go through screening, IVF, transplant, embryo transfer, pregnancy, and deliver…

This study tests whether a bone graft substitute called Genex, combined with core decompression and bone marrow concentrate, can help regrow bone and prevent hip collapse in people with early-stage osteonecrosis (bone death) of the femoral head. Twenty-two adults with this condit…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study looks at whether a specific brain scan feature, called the central vein sign, can help doctors diagnose multiple sclerosis (MS) more accurately. About 420 adults with suspected MS will get MRI scans at the start and after two years. The goal is to see if this sign can …

This study checks if a new, low-cost HPV test (ScreenFire) that women can do themselves works as well as the standard test done by a doctor. About 9,100 women aged 30-59 will take part. The goal is to see if the self-test catches high-grade cervical cancer just as accurately, and…

This study aims to see if a newer MRI contrast agent (Gadopiclenol) can produce clearer images of heart damage in people with atrial fibrillation compared to standard contrast agents. About 50 adults with atrial fibrillation will receive a research MRI scan. The goal is to improv…

This study looks at whether regular, high-intensity indoor cycling can slow down or delay Alzheimer's disease in healthy older adults who carry a specific genetic risk (APOE ε4). About 150 inactive people aged 65-80 will use a Peloton bike at home for a long-term exercise program…

This study looks at whether using a special air cleaning system (ActivePure) in operating rooms can reduce serious infections, complications, and death within 30 days after surgery. Over 66,000 adults having surgery lasting at least one hour are included. The goal is to see if cl…

This study looks at whether giving oral salt tablets along with standard IV diuretics helps hospitalized heart failure patients lose more fluid and protect their kidneys. About 67 adults with fluid overload will be randomly assigned to receive either salt pills or placebo. The ma…

This study tests whether a small device that sends mild electrical pulses through the skin can reduce abdominal pain in adults with gastroparesis-like symptoms (slow stomach emptying). About 140 participants will receive either the real device or a sham (fake) treatment for 4 wee…

This study looks at whether a gluten-free diet can improve quality of life for people with Hashimoto's hypothyroidism who still have symptoms like brain fog, fatigue, and weight gain despite taking thyroid medication. About 50 adults with Hashimoto's and ongoing symptoms will fol…

This study explores whether the way thyroid cancer patients prepare for a radioactive iodine scan affects how much iodine is taken up by breast tissue. Researchers will measure prolactin levels and compare two preparation methods: stopping thyroid hormone or using a synthetic hor…

This study looks at how different breathing machine settings during heart surgery affect patients' recovery. Over 5,500 adults having planned heart surgery with a heart-lung machine are included. The goal is to see if using low air volume and avoiding too much oxygen reduces lung…

This early-phase study at Cleveland Clinic tests whether pairing brain stimulation with hand training can improve hand movement and dexterity in people with cervical spinal cord injury. Seventeen participants will undergo non-invasive stimulation and motor training to see if gain…

This study aims to uncover the genetic factors that contribute to atrial fibrillation, a common heart rhythm disorder. Researchers will collect blood samples and health data from 1300 adults—some with the condition and some without—to build a gene bank. The goal is to better unde…

This study tests whether a simple, non-invasive eye scan can help assess heart failure severity. Researchers will compare retinal images from 250 adults with and without heart failure to see if blood vessel changes in the eye relate to heart function and exercise ability. The goa…

This study aims to find better ways to measure the severity of alcoholic liver disease using advanced MRI scans. Current methods like blood tests and standard imaging often miss ongoing liver damage. By scanning 20 adults with alcoholic liver disease, researchers hope to identify…

This study uses advanced MRI scans to see how knee cartilage is doing 10 years after ACL reconstruction surgery. Researchers will compare the repaired knee to the healthy knee in 219 adults who had an ACL tear from sports. The goal is to learn more about why some people develop p…

This study looks at whether virtual telehealth visits can be as effective as regular in-person clinic visits for people with multiple sclerosis (MS). The goal is to see if virtual care can improve access, reduce costs, and maintain health outcomes. About 120 adults with a recent …

This study tests a new imaging method to measure eye inflammation in people with uveitis. Researchers will see if the scores from this imaging can help doctors decide on treatment. The study involves 50 patients with active or recent eye inflammation.

This study explores whether the characteristics of bone marrow in the upper arm bone are linked to how well torn rotator cuff tendons heal after surgery. Researchers will enroll 50 adults aged 18-75 with full-thickness tears and use MRI and CT scans to measure healing. The goal i…

This study explores whether substances made by gut bacteria can predict high blood pressure during pregnancy. Researchers will follow 200 pregnant women, collecting blood and urine samples throughout their pregnancy. The goal is to find early markers that could help identify at-r…

This study looks at whether the repaired rotator cuff tendon pulling away from the bone (even without a new tear) affects how well patients recover. Researchers will track 125 people having rotator cuff surgery using special markers and scans over 5 years. The goal is to better u…

This study collects blood samples and medical information from nearly 10,000 people who have had heart catheterization or CT scans. The goal is to create a gene bank that researchers can use to study what causes coronary artery disease. Participants provide a blood sample and ans…

This study looks at how bacteria in your gut break down certain nutrients from food, like carnitine (found in red meat) and choline (found in eggs). The goal is to understand how these processes might affect your risk for heart disease. About 100 healthy adults will have their bl…

This study aimed to see if switching from isoflurane to desflurane during surgery could help adults wake up faster and leave the hospital sooner. It was planned as a quality improvement project at Cleveland Clinic for adults having general anesthesia. However, the study was withd…

This study aims to better understand pulmonary hypertension by analyzing the genes, molecules, and cells of 1,195 participants with various heart and lung conditions. The goal is to create more precise definitions of the disease and identify new biomarkers. This research does not…

This study looks at whether watching and discussing videos of their own work can help Ob/Gyn residents get better at laparoscopic suturing. 28 residents will be split into two groups: one gets the usual training, the other also gets three video coaching sessions. The goal is to s…

This study looks at how tight the belly wall is during hernia repair surgery. About 50 adults having a specific type of hernia repair will have their belly wall tension measured with a special scale. Researchers want to see what patient factors affect tension and if tension is li…

This study examines whether removing overactive parathyroid glands (parathyroidectomy) improves blood sugar control in people with both primary hyperparathyroidism and type 2 diabetes. Researchers will compare up to 80 adults who have surgery with those who do not, tracking chang…

This study is looking for new ways to tell Bertolotti syndrome apart from other causes of lower back pain. Researchers will track how 20 people with Bertolotti syndrome and 20 people with other back pain move and report pain during simple tasks. The goal is to find movement patte…

This study looks at how two migraine treatments—CGRP inhibitors and Botox injections—affect bladder symptoms like urgency, frequency, and pain. Researchers will follow 200 women with migraines and bladder issues, using questionnaires before and 3 months after treatment. The goal …

This study looks at whether drinking a beverage with artificial sweeteners like erythritol or xylitol changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure blood and urine levels of these sweeteners and test platelet …

This study aims to better understand blood sugar patterns in people with Polycystic Ovarian Syndrome (PCOS). Participants will wear a continuous glucose monitor on their arm for certain periods over 6 months, have two blood draws, and complete a questionnaire. The goal is to see …

This study interviews 78 pregnant patients and their clinicians to understand what support they need when deciding about prenatal genetic tests and what to do after a diagnosis. The goal is to create better resources and strategies to help patients make informed choices. No treat…

This study looks at how inflammation and oxidation damage cells and whether waste products from these processes in blood or urine can signal heart disease risk. Researchers will follow over 1,200 healthy adults aged 40+ (or 18+ with family history) for years, tracking heart-relat…

This study uses a special light-based technique called Brillouin microscopy to measure how stiff or weak the cornea is in people with keratoconus, a condition that thins and bulges the cornea. Researchers will also look at how the cornea changes after treatments like cross-linkin…