The Cleveland Clinic

This large study aims to reduce the overuse of powerful, broad-spectrum antibiotics in adults hospitalized with pneumonia. Researchers are testing if using faster diagnostic tests at admission and having pharmacists recommend scaling back antibiotics when safe can shorten the tim…

This study is testing whether a specific diet and exercise program can help people with pulmonary arterial hypertension (PAH) by improving how their bodies process sugar (insulin sensitivity). Researchers believe this approach might help control the underlying disease process. Th…

This large study is testing whether changing how patients are ventilated during heart-lung bypass surgery can reduce serious lung problems and death afterward. It involves over 5,500 adults having planned heart surgery at several major hospitals. Researchers are comparing three d…

This study is testing whether a dietary supplement called a ketone ester can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive either the supplement or a placebo for 12 weeks. Doctors will use heart MRI scans to measure c…

This study is testing whether a high-tech coaching app can help people with type 2 diabetes better manage their condition, potentially reducing or eliminating their need for diabetes medications. The app, called a 'Whole Body Digital Twin,' uses AI to analyze daily data on diet, …

This study is testing whether a uterus transplant from a deceased donor can allow women who cannot carry a pregnancy to have a baby. Ten participants will receive the transplant, undergo IVF, and attempt pregnancy while taking medications to prevent organ rejection. The transplan…

This study is testing if giving salt tablets by mouth helps hospitalized heart failure patients lose more fluid when they are also receiving strong IV water pills (diuretics). Researchers want to see if this approach helps patients lose more weight from excess fluid and protects …

This study is testing whether adding mild electrical stimulation to standard care helps heal early-stage bedsores faster and prevents them from getting worse. It will involve about 1,100 hospitalized adults with bedsores on their lower back or buttocks. Participants will be rando…

This study is testing whether a new, non-invasive brain stimulation technique can help improve arm and hand rehabilitation for people with chronic neck-level spinal cord injuries. Researchers are combining this stimulation with specific hand training to try to 'retrain' the brain…

This study tests whether regular multiple sclerosis (MS) care provided through video calls works as well as traditional in-office visits. Researchers are comparing 120 recently diagnosed adults, randomly assigning half to receive check-ups via telehealth and half to continue with…

This pilot trial is testing whether a stricter approach to managing blood pressure during and after major surgery can reduce serious complications. It compares a 'tight management' strategy (using medications to keep blood pressure higher) against usual care in 80 high-risk patie…

This study aims to find the best way to help people maintain weight loss over the long term. It tests if switching from an initial, effective injectable medication to a cheaper oral medication works better than switching to another standard pill. The trial also focuses on a compr…

This study is testing if a single steroid injection given during a common knee surgery can reduce joint inflammation and slow the progression of arthritis. It will involve 150 patients aged 40 and older who are having surgery for a torn meniscus. Researchers will measure pain lev…

This study is testing a special type of MRI scan to see if it can accurately measure how severe alcoholic liver disease is, without needing invasive biopsies. Researchers will scan 20 adults with the disease one time, looking for specific signs in the liver images. The goal is to…

This study aims to test if a new type of MRI contrast dye called Gadopiclenol can create clearer pictures of scar tissue in the hearts of people with atrial fibrillation. Researchers will compare images from this new dye to those from standard dyes in 50 participants. The goal is…

This study is testing a new, low-cost HPV screening test called ScreenFire that women can use at home. It aims to see if this self-collected test works as well as the standard test done by a healthcare provider for detecting early signs of cervical cancer. The study involves 9,10…

This study is testing a new type of microscope that measures the stiffness of the cornea, the clear front part of the eye. Researchers want to see if this tool can better detect a weakening eye disease called keratoconus at its earliest stages and help predict if someone is a goo…

This study is testing if a specific feature seen on MRI scans, called the 'central vein sign,' can help doctors diagnose Multiple Sclerosis (MS) more accurately and quickly. It involves 420 people in North America who have symptoms that are either typical or not typical for MS. T…

This study is testing whether 18 months of high-intensity indoor cycling at home can slow or delay brain changes linked to Alzheimer's disease in healthy older adults who carry a specific genetic risk factor. Researchers will compare 150 sedentary participants aged 65-80, with ha…

This large study is testing whether a special air filtration and sterilization system in operating rooms can prevent serious infections and death after surgery. It will involve over 66,000 patients undergoing operations that last at least an hour. The goal is to see if cleaning t…

This study is testing whether a small device that delivers gentle electrical stimulation to nerves in the ear can help reduce stomach pain in adults with gastroparesis-like symptoms. Participants are randomly assigned to receive either the real stimulation or a sham (fake) treatm…

This study is observing whether certain powerful migraine medications might also help relieve common bladder symptoms like urgency, frequency, and pain. Researchers will follow 200 women with both hard-to-treat migraines and bladder issues. They will compare symptom changes in wo…

This study aimed to see if switching from one common anesthesia drug (isoflurane) to another (desflurane) could help adult surgery patients wake up faster and leave the hospital sooner. The goal was to improve patient flow and potentially reduce costs by shortening recovery time.…

This study aims to understand how to best help pregnant people make informed decisions about prenatal genetic screening and testing. Researchers are interviewing 78 pregnant or recently postpartum patients and their healthcare providers. The goal is to learn what information and …

This study aims to see if video-based coaching helps OB/GYN residents improve their laparoscopic suturing skills. Twenty-eight residents at the Cleveland Clinic will be randomly assigned to either receive standard training materials or those materials plus three personalized coac…

This study aims to understand why some shoulder tendon repairs fail. Researchers will collect bone marrow samples from 50 patients during rotator cuff surgery to see if the quality of the marrow is linked to how well the tendon heals six months later. The goal is to gather inform…

This study aims to understand how the bacteria in our gut process nutrients found in foods like red meat and eggs, and whether this affects heart disease risk. Researchers will examine 100 healthy adults to see if dietary supplements, antibiotics, or probiotics change how these n…

This study aims to understand if drinking a single beverage containing artificial sweeteners (erythritol or xylitol) changes how blood platelets work. Researchers are measuring platelet activity and sweetener levels in the blood and urine of 50 participants before and after they …

This study aims to understand the genetic basis of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples from 1,300 people with and without the condition to create a genetic database. The goal is to identify genes linked to the disease, whi…

This study aims to learn if surgery to remove overactive parathyroid glands (parathyroidectomy) helps improve blood sugar control and bone health in people who also have type 2 diabetes. Researchers will follow 80 patients for a year, comparing those who choose surgery to those m…

This study aims to understand if a substance called TMAO, which is produced by gut bacteria, is linked to developing high blood pressure during pregnancy. Researchers will follow 200 pregnant women, collecting blood and urine samples throughout their pregnancy to measure TMAO lev…

This study aims to see if new, detailed measurements from eye scans can help doctors better manage uveitis, a condition that causes eye inflammation. Researchers will follow 50 patients with uveitis to see if changes in these scan scores reliably match changes in a patient's visi…

This study is testing if a simple, non-invasive scan of the back of the eye (the retina) can help doctors understand how severe a person's heart failure is. Researchers will take pictures of the eyes of 250 people with heart failure to see if changes in the tiny blood vessels the…

This study aims to create a new, more precise understanding of pulmonary hypertension, a condition affecting blood vessels in the lungs. Researchers are collecting a wide range of detailed health data from about 1,200 adults to identify patterns and potential markers of the disea…

This study aims to measure how tight the abdominal wall is during hernia repair surgery. Researchers will use a special scale during the operation on 50 patients to see if this tension affects recovery and hernia recurrence. The goal is to gather information that might help surge…

This study aims to understand how certain chemical reactions in the body might contribute to early heart damage that could lead to heart failure. Researchers are enrolling over 1,200 healthy adults, particularly those aged 40+ or with a family history of heart problems, to measur…

This study aims to understand why breast tissue sometimes shows up on radioactive iodine scans in women treated for thyroid cancer. Researchers are comparing two different preparation methods for the scan to see if one affects a specific hormone (prolactin) more, and if that horm…

This study aims to understand why some people develop knee arthritis years after ACL reconstruction surgery. Researchers will perform detailed MRI scans on 219 people approximately 10 years after their surgery to examine their knee cartilage. The goal is to gather knowledge that …

This study aims to collect blood samples and health information from thousands of patients with heart conditions to create a large gene bank. Researchers will store DNA and medical data to help future studies identify genetic factors linked to coronary artery disease. The goal is…

This study aims to learn more about how blood sugar levels behave in women with polycystic ovary syndrome (PCOS). Participants wear a continuous glucose monitor on their arm for six months to track sugar levels, while researchers check how these patterns relate to other health ma…