New combo treatment aims to save hips from collapse
NCT ID NCT05706909
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bone heal, prevents further collapse, and reduces pain. The trial involves 22 participants and is being run by the Cleveland Clinic.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Genex bone graft substitute with autologous bone marrow concentrate
- What this could lead to
- If successful, this could offer a way to repair bone damage and avoid hip replacement in people with early-stage osteonecrosis.
- What could go wrong
- This is a small, early study with only 22 participants, so results may not apply to everyone. The procedure involves surgery and there is no guarantee it will stop the disease from progressing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
22 people
The number who actually took part.
- Started
-
Feb 2023
- Expected to finish
-
Jul 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who are 18 years or older with early osteonecrosis of the femoral head and meet the inclusion and exclusion criteria based on the protocol.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subject is at least 18 years or older with osteonecrosis of the femoral head * Surgeon considers the patient appropriate for the core decompression procedure of the hip * Subject provides voluntarily signature on the IRB approved Informed Consent Form * Subject must be physically and mentally willing and able, in the Investigator's opinion at the time of enrollment, to be compliant with the protocol and complete the study protocol and follow ups Exclusion Criteria: * Subject is pregnant at the time of surgery * Subject is incarcerated * Subject is not comfortable with speaking, reading and understanding questions and providing responses in an available language for the questionnaires provided for the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
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