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Can brain scans predict suicide risk in teens? new study aims to find out

NCT ID NCT07568054

Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 6 times

Summary

This study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also receive a therapy called CAMS, and their brains will be scanned again to see if the therapy changes brain function. This research may help doctors better predict and treat suicidal behavior in youth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Collaborative Assessment and Management of Suicidality (CAMS) therapy
What this could lead to
If successful, this could help identify brain markers that predict suicide risk and show how CAMS therapy works in the brain, leading to better treatments for at-risk youth.
What could go wrong
This is an early-stage observational study with only 60 participants. It may not find clear brain differences, and results may not apply to all youth. CAMS therapy is already used, but its brain effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 24 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects must be 14-24 years old * Subjects must be: * High Risk Subjects: Psychiatrically admitted due to a suicide attempt or history of 2 previous suicide attempts * Medium Risk Subjects: Suicide ideation for the past year with no suicide attempt * Minimal Risk Subjects: No previous history of suicidal ideation or behavior, not taking any psychiatric history or medication, and no family history of suicide * Subjects must have the ability to understand and the willingness to sign a written informed consent/assent document * Subjects must be English speaking Exclusion Criteria: * Subjects with known history of Autism Spectrum Disorder; non-verbal patients * Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education classes full time) * Subjects with Schizophrenia or history of any type of psychosis including mood related psychosis and brief reactive psychosis * Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for the management of ADHD will not be excluded) * Subjects with a history of moderate or severe substance or alcohol use per DSM-5 criteria in the past 6 months * Subjects who are currently pregnant or breastfeeding * Subjects in custody of Children's Services * Subjects with recent bone, tendon, spine or joint surgery * Subjects with recent metallic dental implants * Subjects weighing less than 30 kg or more than 200 kg

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder Suicidal Ideation Suicide, Attempted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression - major depressive disorder Hopelessness Neurobiological Suicidal behavior Suicidal ideation Suicide attempt

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Cleveland Clinic

    Cleveland, Ohio, 44195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.