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New study aims to uncover why opioid and Anti-Anxiety drug mix is so deadly

NCT ID NCT03696017

Knowledge-focused Sponsor: Wayne State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete interviews, questionnaires, and computer tasks to measure mood, thinking, pain, sleep, and drug use patterns. The goal is to find better ways to prevent and treat this dangerous combination.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could identify key traits that make people more likely to misuse opioids and benzodiazepines together, pointing toward better prevention and treatment strategies.
What could go wrong
This is an observational study with no treatment being tested. It will not directly change patient care, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will either be newly admitted to Substance Use Disorder treatment, or in treatment longer but still occasionally using substances.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Recently admitted and/or not clinically stable in treatment for Substance Use Disorder (SUD) in Wayne County * Using opioids, benzodiazepines (BZD), or BZD/opioid. Exclusion Criteria: * Participants with current psychosis, bipolar disorder, or severe depression (i.e. severe psychiatric disorder) * Individuals with serious neurological disorders, e.g. brain tumor, history of stroke, history of traumatic brain injury w/ loss of consciousness * Cognitive impairment (IQ\<80)

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Conditions

The condition(s) this trial relates to.

opiate dependence polysubstance abuse, susceptibility to substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polysubstance abuse

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tolan Park Medical Building

    RECRUITING

    Detroit, Michigan, 48201, United States

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