SUBSTANCE USE

This study is testing a brief, computerized treatment program designed to help teenagers aged 13-17 who want to cut down on their cannabis and alcohol use. Researchers will enroll 52 teens and their caregivers to see if the program helps reduce substance use over time. The main g…

This study is testing whether participating in a traditional Ojibwe ceremony called Gii'igoshimong can help reduce substance use and improve mental health. Researchers will enroll 300 American Indian adults who have used substances recently, with half participating in the ceremon…

This study tests whether a program where trained peers provide support and problem-solving skills can help people stick to their schedule of long-acting injectable HIV medications (for prevention or treatment) and reduce substance use. It will involve 186 adults, primarily from B…

This study is testing whether a collaborative care program in primary care clinics can help adults with moderate to severe substance use disorders reduce their use of opioids, stimulants, and heavy alcohol. The program involves a team-based approach where primary care providers w…

This study is testing if a smartphone app that gives cash rewards can help people with opioid, cocaine, or methamphetamine addiction stay drug-free. The app tracks participants' progress with at-home drug tests and rewards them with money for clean results. Researchers want to se…

This study aims to see if offering enhanced support to fathers in families at risk of substance misuse improves child well-being and family outcomes. It will enroll 240 fathers from the Bronx and nearby areas who have a child under 18 and a family risk of substance use. Participa…

This study is testing whether a smartphone app called Pink Cloud can help people maintain their recovery from drug or alcohol addiction. The app provides tools like a sobriety tracker, a daily planner, and access to thousands of support group meetings. Researchers will compare re…

This study is testing if ketamine, given through an IV, can help people with moderate to severe methamphetamine addiction reduce or stop their drug use. It will compare ketamine to another sedative drug (midazolam) in 120 adults over 12 weeks. Participants will receive eight IV i…

This study is testing whether giving extra support and training to case managers helps them better use a structured care plan for veterans. The plan focuses on managing pain and risky substance use, especially for veterans who have recently left military service. Researchers want…

This study is testing two support programs to help people who have been involved with the justice system access HIV care, prevention services like PrEP, and employment. Researchers want to see if adding an employment navigator and small financial incentives to a basic health navi…

This study is testing a culturally tailored prevention program called Hastiin Bidziil (Strong Man) designed to reduce substance use among Native American men aged 18-26. The program focuses on cultural strengths and community connection rather than just telling people to stop usi…

This study is testing a new education program called iDECIDE for middle and high school students who recently broke their school's substance use rules. About 300 students will be randomly assigned to either take the 4-week iDECIDE classes right away or be placed on a waitlist. Th…

This study is testing whether a program called 'Bright Horizons' can help Native American teenagers reduce binge drinking and drug use. The program teaches skills for managing emotions, solving problems, and setting goals to avoid substance use. Researchers are enrolling 100 teen…

This study is testing a 10-week after-school program called Native Spirit, designed to prevent substance use among Indigenous adolescents. The program uses local cultural values and activities to strengthen cultural identity, self-esteem, and resilience. Researchers will enroll a…

This study is testing two different ways to screen teenagers for alcohol and drug use during regular doctor's visits. One method works with the teen alone, while the other actively involves their parent or caregiver. Researchers want to see which approach is more effective at ide…

This study is testing a new peer-led workshop program for young people in vocational training in Zambia, Zimbabwe, and South Africa. The goal is to see if group sessions focused on reducing substance use and promoting fairer gender beliefs can improve health and life outcomes. It…

This study is testing whether a 6-session talk therapy is practical and helpful for cancer patients who are taking opioid pain medication and are at risk for misusing it. The therapy helps patients cope with difficult thoughts and feelings related to their cancer. About 40 adult …

This early-stage study from Yale University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people whose daily lives are impacted by symptoms of depression, anxiety, trauma, or addiction. The study will enroll 50…

This study aims to understand why transgender people in Thailand use drugs during sex (chemsex) and what kind of support services they need. Researchers will interview transgender chemsex users, their partners, and healthcare workers to gather different perspectives. The goal is …

This study aims to see if brain scans can predict how well teens respond to a cannabis treatment program. Researchers will scan the brains of 80 teens (ages 14-17) who use cannabis, then have them join 10 weeks of virtual sessions where they report use and take drug tests. Teens …

This University of Michigan study aims to understand how different personality traits and brain patterns relate to substance use behaviors in young adults. Researchers will use brain scans and behavioral tests to examine 294 participants aged 18-20. The study focuses on observing…

This study aims to understand how racial discrimination affects alcohol and drug use among Black teenagers involved with the justice system. Researchers will conduct interviews with youth and focus groups with parents and community advocates to gather insights. The information wi…

This study aims to understand the health, stress levels, and wellbeing of university students and employees. Researchers will use surveys and interviews to gather information on factors like loneliness, anxiety, and substance use. The goal is to use this data to help guide and im…