SUBSTANCE USE

This study looks at whether taking part in a traditional Ojibwe ceremony called Gii'igoshimong can help American Indian adults cut down on substance use and improve their mental health. About 300 adults who identify as Ojibwe/Anishinaabe/Chippewa and have used substances in the p…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the desire to drink and lower heavy drinking days in people with alcohol use disorder. About 86 adults who drink heavily will receive either real or fake (sham…

This study tests two types of support for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation, and the other gets extra help finding a job and money for health and career goals. The goal is to see which approach helps…

This study tests a program called Family Spirit Strengths to help Native American and Alaska Native mothers and caregivers manage depression, anxiety, and substance use. About 188 participants will either receive the skills program or a nutrition education program. The goal is to…

This study tests whether a program led by peers—combining acceptance and commitment therapy, exercise, and social support—can help women living with HIV take their medication more consistently. About 300 women who have HIV, use substances, and have experienced violence will take …

This study tests a program to help veterans manage pain and reduce risky substance use after leaving the military. About 1,800 veterans will be assigned to either standard training for case managers or extra support to adopt a new care pathway. The goal is to see if extra support…

This study tests whether a low dose of ketamine, given through an IV, can help people reduce or stop using methamphetamine. It involves 120 adults with moderate to severe methamphetamine use disorder. Participants will receive either ketamine or a placebo (midazolam) over six wee…

This study tests a 6-month behavioral health program for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants get counseling, peer support, and education tailored to their needs. Researchers will measure changes in depression, anxiety, substan…

This study tests whether trained peer supporters can help Black individuals living with or at high risk for HIV stay on track with long-acting injectable HIV medication (PrEP/ART) and reduce substance use. About 186 participants will receive either peer-delivered problem-solving …

This study tests a program called Hastiin Bidziil (Strong Man) to help Native American men reduce their use of alcohol and drugs. About 160 men aged 18 and older who live near Fort Defiance or Chinle, Arizona will take part. The program uses cultural strengths to support healthie…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for or living with HIV and also have substance use issues. The program provides support to start HIV prevention medicine (PrEP) or to lower the amount of virus in the body for those alread…

This study tests a 10-session after-school program called Native Spirit for Indigenous teens in grades 7-12. The program uses cultural activities to strengthen identity, self-esteem, and resilience, with the goal of preventing substance use. About 60 participants from two Arizona…

This study is testing a program called Bright Horizons to see if it can help prevent binge drinking and drug use in Native American teens aged 12 to 17. The program teaches skills like managing emotions, coping with stress, and setting goals to avoid substance use. About 100 teen…

This study tests a brief computer program designed to help teenagers ages 13-17 reduce their use of cannabis and alcohol. Participants are teens who already use both substances and want treatment. The program aims to change their automatic reactions to drug cues, and researchers …

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study is testing whether a smartphone app called Pink Cloud can help people recovering from alcohol or drug use stay sober and have fewer problems related to substance use. About 1,410 adults in recovery will be randomly assigned to use the app or not, and researchers will c…

This study looks at how young adults (ages 18-22) differ in their attention, impulse control, and brain responses to rewards. Researchers want to see if these differences are linked to cannabis use. Participants will complete tasks and brain scans to help understand these pattern…

This study compares two approaches to help teens reduce alcohol and drug use: one that talks only with the teen, and another that includes the whole family. About 2,300 teens (ages 12-17) and their caregivers will take part during regular doctor visits. Researchers will track cha…

This study tests a peer-led program called PEGISUS to see if it can reduce substance use and promote fair gender attitudes among young people in vocational training in Zambia, Zimbabwe, and South Africa. About 264 participants aged 16-24 who use alcohol or drugs at least weekly w…

This study is a health check for about 363 students and employees at Constructor University Bremen and HAW Hamburg. Researchers will use questionnaires and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects well-being, not…

This study is creating and testing a 12-week educational program to help Black young adults (ages 18-35) who have experienced trauma and may use substances. The program aims to improve their understanding of mental health, reduce stigma, and encourage seeking help. Researchers wi…

This study tests two types of reward programs to help people with opioid, cocaine, or methamphetamine use disorders stay abstinent. Participants use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to find the b…

This study looks at whether special programs for fathers can help children in families where substance misuse is a concern. About 240 fathers in the Bronx and nearby areas will be split into two groups: one gets usual services, the other gets extra support like motivation session…

This study looks at whether a telehealth program called Project REACH can help people who use drugs get HIV prevention and treatment services. About 121 participants will be recruited from syringe service programs. The goal is to see if the program is practical and acceptable, no…

This study looks at whether adding conversations about sexual pleasure to existing harm reduction services helps men and transgender people who use drugs in Thailand. Researchers will use a tool called the Pleasuremeter to measure sexual satisfaction and willingness to discuss pl…

This study aims to adapt alcohol and drug treatment to better fit the experiences of Black teenagers on probation. Researchers will interview teens and hold group discussions with parents and community advocates to understand how racial discrimination affects substance use. The g…

This study is testing a harm reduction service designed specifically for transgender women, transgender men, and non-binary people in Thailand who have used substances or engaged in chemsex in the past year. The service aims to increase uptake of HIV prevention medication (PrEP),…

This study tests a parenting program called Parenting in 2 Worlds (P2W) for American Indian parents and guardians living in cities. The program aims to improve family relationships and reduce risky behaviors like substance use and depression in teens aged 12-17. About 1,440 famil…

This study talks to men who have sex with men and take part in chemsex (using drugs during sex) in Bangkok. Researchers want to understand the physical, mental, and social harms they face. The goal is to design a program led by hosts of chemsex parties to reduce risks like HIV, S…

This study looks at whether brain activity related to learning can predict how well teens (ages 14-17) respond to a program aimed at reducing cannabis use. Participants get a brain scan, then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study looks at whether harm reduction care—where healthcare providers focus on reducing harm rather than judging drug use—can improve health outcomes and reduce stigma for people living with HIV who use drugs. Researchers will study about 768 patients and their providers at …

This study tests a program called iDECIDE for about 300 middle and high school students who recently broke their school's drug rules. Instead of punishment, students take a course on drug effects, brain development, and marketing tactics. Researchers will check if it improves the…

This study talks to transgender people about their experiences with chemsex (using drugs during sex) to learn why they do it, the good and bad effects, and what kind of help they need. Researchers will also ask healthcare workers and community leaders about barriers to providing …