Substance use

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This completed study tested a program called RISE (Resiliency in Stressful Experiences) for young men ages 18-35 leaving state prisons in Florida. The program combines trauma counseling with practical help like housing and job support. Researchers measured whether participants ha…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested two versions of a remote therapy program for teens (ages 14-24) who came to the emergency room for a violent injury. One version was standard, the other used artificial intelligence to adapt the therapy in real time. The goal was to see if the AI version could b…

This study tested different combinations of three programs—New Hope (coping skills), Elders Resilience (cultural strength), and Case Management—to see which best reduces suicidal thoughts and builds resilience in American Indian youth ages 10-29. The 304 participants were identif…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study tested whether a new personalized feedback program helps young adults ages 18-25 reduce risky alcohol and drug use. Researchers enrolled 660 participants across the U.S. and measured changes in drinking, drug problems, and readiness to change. The goal is to prevent su…

This study tests whether a single counseling session aimed at reducing stigma can help Black men who have sex with men and use substances stay on PrEP, a daily pill that prevents HIV. Participants receive the counseling and are monitored for PrEP adherence through biological test…

This study tested a program called Trust-based Relational Intervention (TBRI) to prevent opioid and other drug use in 250 teens aged 15-18 who were leaving juvenile justice facilities. Each teen worked with a trusted adult to build supportive relationships. The goal was to see if…

This study tested two strategies to prevent HIV among young couples (ages 18-30) in Cape Town who use alcohol or drugs. One strategy was a community workshop to reduce stigma around HIV and drug use. The other was a couples program that provided HIV testing and counseling to help…

This pilot study tested whether involving young people in designing and running substance misuse prevention programs makes those programs more effective. Four community organizations in North Carolina took part; some used the youth engagement approach while others did not. Resear…

This study tested whether giving homeless young people (ages 18-24) a place to live plus support services could help them avoid developing opioid use disorder. 240 participants who were homeless but did not yet have opioid addiction were randomly assigned to receive either housin…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and helpful for bui…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study tested a digital toolkit designed to help leaders in child welfare and substance use treatment agencies choose partners and build effective collaborations. Nine implementation support professionals in Ohio used the guide and rated how acceptable, appropriate, and feasi…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study tested a program where trained peer providers help young people with early psychosis reduce or stop using alcohol and drugs. 113 participants from coordinated specialty care teams took part. The goal was to see if the program could be delivered as planned and whether i…

This study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…