COCAINE USE DISORDER
Clinical trials for COCAINE USE DISORDER explained in plain language.
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Could an Anti-Inflammatory drug curb cocaine cravings?
Disease control Recruiting nowThis early-stage study tests whether pentoxifylline, a drug that reduces inflammation, can lessen the rewarding effects of cocaine. About 30 adults with cocaine use disorder who are not seeking treatment will take part. Researchers will measure how often participants choose cocai…
Matched conditions: COCAINE USE DISORDER
Phase: EARLY_PHASE1 • Sponsor: William Stoops • Aim: Disease control
Last updated May 26, 2026 03:51 UTC
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Could a diabetes drug help curb cocaine cravings?
Disease control Recruiting nowThis study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cravings and use. About 75 adults with a BMI of 25 or higher will receive semaglutide along with counseling. Researchers will measure brain respo…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated May 26, 2026 03:46 UTC
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Zapping the brain to beat cocaine cravings
Symptom relief Recruiting nowThis study tests whether a gentle brain stimulation technique called tDCS can reduce cravings in people with cocaine addiction. 120 adults will receive the stimulation while doing cognitive tasks, and brain scans will measure changes. The goal is to develop a tool patients can us…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated May 26, 2026 03:34 UTC
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Can a blood pressure drug curb cocaine cravings?
Symptom relief Recruiting nowThis study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will be randomly assigned to receive either clonidine or an active placebo (clonazepam). The main goal is to see if cl…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE4 • Sponsor: University of Sao Paulo General Hospital • Aim: Symptom relief
Last updated May 20, 2026 11:57 UTC
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Can cash rewards and a smartphone app help beat addiction?
Knowledge-focused Recruiting nowThis study tests two types of reward programs to help people with opioid, cocaine, or methamphetamine use disorders stay abstinent. Participants use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to find the b…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated May 26, 2026 03:49 UTC
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Scientists track body clocks of crack users to uncover addiction patterns
Knowledge-focused Recruiting nowThis study aims to observe how crack cocaine use affects movement and sleep in 20 people with severe addiction. Participants will wear a motion-tracking device for 3 weeks and have blood tests to look for biological markers. The goal is to better understand a behavior called beha…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated May 26, 2026 03:37 UTC
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Sleep trackers reveal cocaine Withdrawal's toll on rest
Knowledge-focused Recruiting nowThis study follows 32 people with cocaine use disorder during inpatient detox to understand how their sleep changes from active use through early and late withdrawal. Using wearable devices and hormone tests, researchers will compare objective sleep data with how well participant…
Matched conditions: COCAINE USE DISORDER
Sponsor: Hôpital le Vinatier • Aim: Knowledge-focused
Last updated May 26, 2026 03:34 UTC
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Brain scans reveal Cocaine's impact on synaptic connections
Knowledge-focused Recruiting nowThis study uses a special PET scan to measure the density of synapses (connections between brain cells) in people with cocaine use disorder compared to healthy volunteers. Researchers aim to understand how cocaine affects brain plasticity. The study involves 80 participants aged …
Matched conditions: COCAINE USE DISORDER
Sponsor: Yale University • Aim: Knowledge-focused
Last updated May 20, 2026 11:53 UTC