COCAINE USE DISORDER
Clinical trials for COCAINE USE DISORDER explained in plain language.
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Could a diabetes drug help people stay off cocaine?
Disease control CompletedThis study looked at whether pioglitazone, a medicine used for diabetes, can help people who recently stopped using cocaine stay drug-free when combined with cognitive behavioral therapy. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brai…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated May 26, 2026 04:35 UTC
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New pill may blunt Cocaine's high and heart risks
Disease control CompletedThis early-stage study tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in 21 adults who use cocaine but are not seeking treatment. Participants received either STP7 or a placebo, then were given intravenous cocai…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE1 • Sponsor: Stalicla SA • Aim: Disease control
Last updated May 26, 2026 04:33 UTC
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New drug combo shows promise in cocaine addiction trial
Disease control CompletedThis study tested whether a combination of two long-acting medications (extended-release naltrexone and extended-release buprenorphine) can help people reduce or stop using cocaine. Over 400 adults who wanted to cut down on cocaine took part in the 8-week trial. The main goal was…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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Could a bipolar medication curb cocaine use in opioid patients?
Disease control CompletedThis study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: Kyle Kampman • Aim: Disease control
Last updated May 22, 2026 14:01 UTC
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Antibiotic may dull painful memories in PTSD and addiction
Symptom relief CompletedThis study tested whether minocycline, an antibiotic, could reduce the frequency and intensity of intrusive memories in people with PTSD or cocaine use disorder. 138 participants took the drug and reported changes in their memories using smartphone surveys. The goal was to see if…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Psychiatric University Hospital, Zurich • Aim: Symptom relief
Last updated May 26, 2026 04:39 UTC
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Thinking ahead may curb cocaine cravings, study finds
Knowledge-focused CompletedThis study tested a technique called Episodic Future Thinking in 141 people with cocaine use disorder who wanted to cut down. Participants practiced imagining positive future events to see if it would help them make less impulsive choices and reduce their desire for cocaine. The …
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Virginia Polytechnic Institute and State University • Aim: Knowledge-focused
Last updated May 26, 2026 04:43 UTC
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Brain scans may predict which veterans beat cocaine addiction
Knowledge-focused CompletedThis study looked at brain activity and thinking skills in 63 veterans with cocaine use disorder to see if they could predict who would benefit from a behavioral treatment called contingency management. The treatment rewards patients for staying cocaine-free. The goal was to unde…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Can a supplement curb cocaine cravings during opioid withdrawal?
Knowledge-focused CompletedThis study looked at how the brain chemical glutamate changes in people who use both opioids and cocaine. Researchers tested whether a supplement called N-acetylcysteine (NAC) could reduce cravings for cocaine during opioid withdrawal. Twelve adults with opioid and cocaine use di…
Matched conditions: COCAINE USE DISORDER
Phase: EARLY_PHASE1 • Sponsor: William Stoops • Aim: Knowledge-focused
Last updated May 19, 2026 11:59 UTC