Could a bipolar medication curb cocaine use in opioid patients?
NCT ID NCT05063201
First seen Jan 24, 2026 · Last updated May 20, 2026 · Updated 15 times
Summary
This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks, with 26 participants receiving either cariprazine or a placebo, and urine tests tracked cocaine use. The goal was to see if cariprazine could lower the number of cocaine-positive urine samples.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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