COCAINE USE DISORDER

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses, cravings, and d…

This study tests whether a slow-release form of dexamphetamine, a drug used for ADHD, can help people with cocaine and opioid addiction reduce their cocaine use. About 204 adults who are already on methadone for opioid addiction will receive either dexamphetamine or a placebo for…

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests a computer training called Approach Bias Modification (ABM) to see if it can reduce cocaine cravings and increase days of abstinence. Sixty adults with cocaine use disorder will either receive ABM training plus usual care or usual care alone. The training involve…

This study tests whether a gentle brain stimulation technique called tDCS can lower cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and brain scans will track changes. The goal is to see if this approach can hel…

This study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The main goal is to see if craving…

This study uses a special brain scan (PET) to compare the number of connections between brain cells in people with cocaine use disorder versus healthy volunteers. Researchers want to see if these connections change after three weeks of staying off cocaine. The study does not test…

This study uses brain scans (PET) to measure how much dopamine is released after a low dose of amphetamine in people with cocaine use disorder. Researchers want to understand brain changes linked to addiction. About 30 adults aged 18-55 with cocaine use disorder will participate.…

This study uses brain scans to see how stress hormones interact with certain brain receptors in people with cocaine use disorder. Researchers will compare 80 adults with and without the disorder to understand these interactions and whether they predict relapse. The goal is to lea…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study follows 32 adults with cocaine use disorder during inpatient detox to track how their sleep changes from active use through withdrawal. Using wearable devices and hormone tests, researchers measure both objective and subjective sleep quality. The goal is to understand …